Risk of post‐colonoscopy colorectal cancer due to incomplete adenoma resection: A nationwide, population‐based cohort study

Abstract

Approximately one-third of PC-CRCs are found in the same colorectal segment after adenoma resection and could therefore be a consequence of incomplete adenoma resection, occurring in one in 400 adenomas. The risk of PC-CRC in the same segment is increased in adenomas with high-grade dysplasia or (tubulo)villous histology.

Thermal Ablation of Mucosal Defect Margins Reduces Adenoma Recurrence After Colonic Endoscopic Mucosal Resection

“…Post colonoscopy interval cancers account for up to 6% of all CRCs, 28,29 a proportion of which are believed to be due to incomplete polyp excision/destruction. 30 Taken together with the CARE study results, this indicates that conventional polypectomy for smaller lesions <20 mm is an imperfect and highly operator-dependent technique. It is conceivable that the implementation of this simple, readily learned, and inexpensive adjuvant technique after removal of smaller colonic polyps could significantly impact the effectiveness of conventional polypectomy and thereby interval cancer.…”

Clinical and endoscopist factors associated with post‐colonoscopy colorectal cancer in a population‐based sample

“…Reported rates of post-colonoscopy CRC (PCCRC) range from 0.96% [1] to 12.1% [2] of patients who undergo non-diagnostic colonoscopy.…”

En Bloc Resection for 10–20 mm Polyps to Reduce Post Colonoscopy Cancer and Surveillance

“…An alternative consideration is the risk of an incomplete polypectomy at baseline colonoscopy. Incomplete polypectomy accounts for up to one-third of postcolonoscopy CRC, 7,8 often occurring early after the baseline colonoscopy. This may explain, at least in part, the higher risk of postcolonoscopy CRC in patients with high-risk adenomas without endoscopic surveillance, 5,9 and in those with 20 mm or proximal lesions.…”