Clinical and endoscopist factors associated with post‐colonoscopy colorectal cancer in a population‐based sample

Abstract

Aim: Factors associated with verified post-colonoscopy colorectal cancers (PCCRC) have not been well defined and survival for these patients is not well described. We aimed to assess the association of patient, tumour and endoscopist characteristics with PCCRC. Methods: Using population-based data, we identified individuals diagnosed with CRC from 1 January 2000 to 31 December 2005 who underwent a colonoscopy within 3 years prior to diagnosis. Detected cancers were those diagnosed ≤6 months following colonoscopy; PCCRC were diagnosed >6 months to ≤3 years following colonoscopy. Post-colonoscopy and detected cancers were verified through chart review using a hospital-based simple random sampling frame. We used multivariable conditional logistic regression to determine the association of patient, tumour and endoscopist factors with PCCRC and compared overall survival using Cox proportional hazard models. Results: Using the random sampling frame, we identified 498 patients with PCCRC and 498 with detected CRC; we obtained records and confirmed 367 patients with PCCRC and 412 with detected cancers. In multivariable analysis, patient age (OR 1.01; 95% CI 1.00-1.03) and tumour location (distal vs. proximal OR 0.36; 95% CI 0.25-0.53

Analysis of Post-Colonoscopy Colorectal Cancer and Its Subtypes in a Screening Programme

“…Like in the study carried out by Mlakar et al in 2018 in Slovenia [25] our results did not show statistically significant differences either according to age, sex, location of the tumour or deprivation index among the two types of PCCRC detected. With regard to the location of the CRC, the results of our study differ from those of Dossa et al due to the fact that although a higher frequency of CRC in distal colon was observed (38% and 37.2%) in both interval type and non-interval type PCCRCs in our study, they observed that the majority of cases were located in the proximal colon (54.2% of 367 PCCRCs) [26]. However, it should be noted that these studies included persons with symptoms with previous pathologies such as inflammatory bowel disease, hereditary syndromes, previous CRC, polyposis or diverticulosis.…”

Postcolonoscopy colorectal cancer: in defence of quality

“…We thank Spychalski et al for their comments on our recent study evaluating factors associated with the development of postcolonoscopy colorectal cancer (PCCRC) [1]. In this study of 367 patients with confirmed PCCRC and 412 patients with confirmed detected colorectal cancer (CRC) we showed that patient age and tumour location were most strongly associated with PCCRC and that endoscopist‐associated quality metrics that could be derived from an administrative dataset were not significantly associated with PCCRC.…”

Type 2 diabetes mellitus and post-colonoscopy colorectal cancer: Clinical and molecular characteristics and survival

“…Our survival analyses indicated that PCCRC was associated with poorer one-year and one-to ve-year survival than dCRC. Despite some con icting results, the majority of previous studies found no difference in the prognosis for patients with dCRC and PCCRC (2,(26)(27)(28)(29)(30)(31). These studies have led to the interpretation of PCCRC as CRC arising mainly from missed or insu ciently resected precursor lesions.…”