Risk factors for tuberculosis in dialysis patients: a prospective multi-center clinical trial

Christopoulos, Antonios; Διαμαντόπουλος, Αθανάσιος; Dimopoulos, Panagiotis; Goumenos, D. S.; Barbalias, George A.

doi:10.1186/1471-2369-10-36

Cited by 53 publications

(44 citation statements)

References 22 publications

(28 reference statements)

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“…¾ Persons with chronic renal failure and also persons on hemodialysis have an increased risk for TB [22].…”

Section: Risk Factors Associated With Tbmentioning

confidence: 99%

Role of Diabetes in prevalence of Tuberculosis

Siddiqui¹

2012

J Diabetes Metab

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Tuberculosis is a lethal disease caused by Mycobacterium tuberculosis. The Mycobacterium initially infects lungs. If the infection spreads beyond the lungs, the symptoms will depend upon the individual organs. Diabetes is a type of metabolic disease in which a person has increased blood sugar level. It's because the body does not produce enough insulin or the cells inside the body do not respond to the insulin that is produced. Diabetics have a three to five time's higher risk of developing tuberculosis (TB) than those without diabetes disease. Diabetes mellitus is an important risk factor for tuberculosis and may affect disease treatment and also the response. Additionally tuberculosis may induce glucose intolerance and worsen the glycaemic control in people with diabetes. The main aim of this Review is to evaluate the epidemiology of diabetes mellitus and tuberculosis disease, the effect of diabetes mellitus on tuberculosis and vice versa.  When the immune system of a patient with dormant TB is weakened, the TB can become active (reactivate) and cause infection in lungs or any other parts of the body. The risk factors for acquiring TB include close-contact situations, alcohol, drug abuse and certain diseases (examples include diabetes, cancer, and HIV) and occupations (for example, health-care workers). The common signs and symptoms of TB include fatigue, fever, weight loss, coughing, and night sweats. The diagnosis of TB involves skin tests, chest X-rays, sputum analysis (smear and culture), and PCR tests to detect the genetic material of the causative bacteria or causative agent [12]. Inactive tuberculosis may be treated with an isoniazid (INH), antibiotic, in order to prevent the TB infection from becoming active. Active TB is usually treated, successfully, with INH in combination with one or more of several drugs, including rifampin (Rifadin), ethambutol (Myambutol), pyrazinamide, and streptomycin [13].

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“…¾ Persons with chronic renal failure and also persons on hemodialysis have an increased risk for TB [22].…”

Section: Risk Factors Associated With Tbmentioning

confidence: 99%

Role of Diabetes in prevalence of Tuberculosis

Siddiqui¹

2012

J Diabetes Metab

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“…In a multicenter clinical trial in Greece by Christopoulos et al [10], the investigators showed that elderly (aged C70 years), underweight, tuberculin-positive, hemodialysis (B12 months duration) patients with diabetes and fibrotic lesions are at risk of developing TB.…”

Section: Discussionmentioning

confidence: 99%

A case of disseminated tuberculosis after the initiation of hemodialysis

Hasegawa

Wakai

2013

CEN Case Rep

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A 67-year-old man with diabetes mellitus, chronic kidney disease, chronic heart failure, and amputation of the left lower limb was admitted to our hospital with decreasing renal function. On admission, he was started on hemodialysis. He simultaneously developed a urinary tract infection, infected necrotic wound of the right lower limb, and pneumonia, and was treated with broad-spectrum antibiotics. Although his general condition improved, fever and anorexia persisted and jaundice worsened. He died 138 days after admission. Autopsy revealed granulomas in the lungs, liver, and spleen. Cultures revealed Mycobacterium tuberculosis, leading to the diagnosis of disseminated tuberculosis.

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“…Incidence of active tuberculosis in the patients treated with long-term dialysis is 6.9-52.5 higher than in the general population of the same region. The additional risk factors in this group of patients are the following: advanced age, diabetes mellitus, the presence of fibrotic lesions on chest X-ray and the period of dialysis exceeding 12 months [38]. In addition, the effect of antituberculous therapy is worse in this group than in controls without uremia.…”

Section: End Stage Renal Disease With Uremiamentioning

confidence: 99%

“…There are profound alterations in immune responses associated with uremia and exacerbated by dialysis [38]. Those changes were associated with impaired activation of T lymphocytes [39] and macrophages [40].…”

Section: End Stage Renal Disease With Uremiamentioning

confidence: 99%

What Factors May Influence Epidemiological Situation of Tuberculosis in Poland and in the World?

Rowińska-Zakrzewska¹,

Korzeniewska-Koseła²,

Augustynowicz–Kopeć³

et al. 2016

Advances in Respiratory Medicine

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The authors present the review of factors influencing epidemiological situation of tuberculosis in Poland and in the world. The groups of increased risk of tuberculosis, and clinical conditions predisposing to activation of latent tuberculosis infection (LTBI) such as HIV, uremia, diabetes mellitus, transplantation of organs, treatment with glucocorticosteroids and with antibodies to TNF and to its receptors, were presented. The higher prevalence and worse prognosis of tuberculosis in elderly people was emphasised. The methods of LTBI recognition, according to recent recommendations, with special consideration to patients in immunosupression, were shown. Methods of treatment to prevent LTBI activation, according to WHO experts, were also presented. All data were discussed in relation to the actual epidemiological situation of tuberculosis in Poland.

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Risk factors for tuberculosis in dialysis patients: a prospective multi-center clinical trial

Cited by 53 publications

References 22 publications

Role of Diabetes in prevalence of Tuberculosis

Role of Diabetes in prevalence of Tuberculosis

A case of disseminated tuberculosis after the initiation of hemodialysis

What Factors May Influence Epidemiological Situation of Tuberculosis in Poland and in the World?

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