Risk factors and predictors of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter baumannii mortality in critically ill bacteraemic patients over a 6-year period (2010–15): antibiotics do matter

Abstract

KPC-Kp infection predisposes ICU patients to BSI by either A. baumannii or P. aeruginosa. The administration of at least one active antibiotic leads to better survival rates.

Predictors of mortality in patients infected with carbapenem-resistant Acinetobacter baumannii: A systematic review and meta-analysis

“…The remaining 98 full-text articles were assessed for eligibility. Nineteen studies [11][12][13]19,20,[23][24][25][26][27][28][29][30][31][32][33][34][35][36] were included in the systematic review based on the inclusion and exclusion criteria. The detailed process of search and selection is shown in Fig 1.…”

“…Among the eligible articles, 10 studies 13,20,[24][25][26]28,31,32,34,35 including 923 patients were performed on bacteremia, the pooled mortality of which was 56.3%. We assessed the risk factors previously considered to induce mortality among patients with CRAB bacteremia.…”

“…For instance, whereas most relevant studies report a positive correlation between mechanical ventilation and fatality, 11,12 others draw an opposite conclusion. 13 The impact of some underlying diseases (such as chronic renal disease) on the mortality caused by CRAB infection is also a matter of debate. 12,13 Therefore, we conducted a systematic review and meta-analysis to evaluate the relation between possible risk factors and mortality in patients with CRAB infection.…”

“…13 The impact of some underlying diseases (such as chronic renal disease) on the mortality caused by CRAB infection is also a matter of debate. 12,13 Therefore, we conducted a systematic review and meta-analysis to evaluate the relation between possible risk factors and mortality in patients with CRAB infection. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.…”

Antibiotic resistance rates among bacterial isolates from infected patients of intensive care unit over the period (2011-2016) in Bursa, Turkey

“…Recently, most ICU-acquired infection are due to pathogens like methicillin-resistant Staphylococci, multidrug-resistant Pseudomonas aeruginosa and Acinetobacter species. Additionaly, carbapenem resistant K. pneumoniae (CR-KP) are detected more frequently in the recent years worldwide [3][4][5]. Therefore, awareness about the current local epidemiology and antimicrobial susceptibility of bacterial isolates is an important factor in prescribing true empiric antibiothreapy in ICU [6,7].…”