Rift Valley Fever Virus: Some Ultrastructural Observations on Material from the Outbreak in Egypt 1977

Ellis, D. S.; Simpson, David; Stamford, Susan; Wahab, Kouka S. E. Abdel

doi:10.1099/0022-1317-42-2-329

Cited by 39 publications

(21 citation statements)

References 2 publications

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“…The most common ocular involvement reported in an East Indian population was a petechial type of subconjunctival hemorrhage (37%), which was associated with a platelet count of <50,000 μl. [9] The fundal manifestations typically occur 1 week after the onset of fever, just as the fever has settled, and the platelet count is recovering. [101112] It generally presents bilaterally.…”

Section: Discussionmentioning

confidence: 99%

Anterior ischemic optic neuropathy following dengue fever

Ramakrishnan¹,

Shrivastava²,

Deshpande³

et al. 2016

Oman J Ophthalmol

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Dengue fever is caused by a flavivirus. This infection is endemic in the tropics and warm temperate regions of the world. Ocular manifestations of dengue fever include subconjunctival, vitreous, and retinal haemorrhages; posterior uveitis; optic neuritis; and maculopathies, haemorrhage, and oedema. However anterior ischemic optic neuropathy is a rare presentation. Optic nerve ischemia most frequently occurs at the optic nerve head, where structural crowding of nerve fibers and reduction of the vascular supply may combine to impair perfusion to a critical degree and produce optic disc oedema. Here we present a case of anterior ischemic optic neurapathy associated with dengue fever.

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Section: Discussionmentioning

confidence: 99%

Anterior ischemic optic neuropathy following dengue fever

Ramakrishnan¹,

Shrivastava²,

Deshpande³

et al. 2016

Oman J Ophthalmol

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“…The presence of these inclusions in intact hepatocytes indicates an early infection of these cells 25. Ellis et al 26 reported that RVF's inclusions formed of either fine or coarse materials.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural pathology of human liver in Rift Valley fever

et al. 2016

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Rift Valley fever (RVF) is a zoonotic disease that primarily affects ruminant animals and can also cause fatal disease in humans. In the current report, we present the ultrastructural changes in the liver of a man aged 60 years who died from RVF in the Aseer Central Hospital, Abha, Saudi Arabia. The main hepatic changes by transmission electron microscopy included the presence of 95-115 nm electron-dense particles consistent with RVF virions, nuclear condensation, vacuolar degeneration, lipid droplet accumulation and mitochondrial damage and dilation. There were also viral inclusion bodies with electron-dense aggregates, dilation of intercellular spaces, damage of sinusoidal microvilli with widening of space of Disse, dilation of bile canaliculi and increasing number of phagolysosomes.

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“…The question may be raised as to whether these morphological findings re present such unique features of the HFRS viruses that they should be classified separ ately. Previous morphological and morpho genetic studies have indicated that all the bunyaviruses are similar in overall shape, size and internal structure [7][8][9][10][11]. The mor phogenesis of the bunyaviruses appears to be distinct from that of the orthomyxoviruses, paramyxoviruses and rhabdoviruses; unlike these viruses, the bunyaviruses lack a matrix protein [12].…”

Section: Discussionmentioning

confidence: 99%

Morphology and Morphogenesis of Viruses of Hemorrhagic Fever with Renal Syndrome (HFRS)

Hung¹,

Chou²,

Zhao³

et al. 1985

Intervirology

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The morphology and morphogenesis of viruses of hemorrhagic fever with renal syndrome (HFRS) were studied by thin-section electron microscopy. Ten strains of HFRS virus isolated in China and one strain isolated in Korea were compared. The virions varied in size as well as in the shape and character of their inner components. Both intracellular and extracellular ribosome-like, electron-dense, virus-associated granules were seen. A viral antigen layer was often visualized on the surface of HFRS virus-infected cells, as confirmed by immune electron microscopy. Aberrant tailed particles and elongated rod-like particles were seen infrequently. The morphogenesis of HFRS viruses appears to be more complex than that of other members of the family Bunyaviridae. The prototype Hantaan virus shares a common morphology and morphogenesis with the other HFRS viruses studied.

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Rift Valley Fever Virus: Some Ultrastructural Observations on Material from the Outbreak in Egypt 1977

Cited by 39 publications

References 2 publications

Anterior ischemic optic neuropathy following dengue fever

Anterior ischemic optic neuropathy following dengue fever

Ultrastructural pathology of human liver in Rift Valley fever

Morphology and Morphogenesis of Viruses of Hemorrhagic Fever with Renal Syndrome (HFRS)

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