Morphology and Morphogenesis of Viruses of Hemorrhagic Fever with Renal Syndrome (HFRS)

Hung, Tao; Chou, Zhi-guang; Zhao, Tingxiao; Xia, Shi Mao; Chen, Hang

doi:10.1159/000149591

Cited by 21 publications

References 9 publications

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Electron microscopic study of the morphology and morphogenesis of virus of hemorrhagic fever with renal syndrome

Chen

Yang

Wang

et al. 1987

J. Elec. Microsc. Tech.

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The morphology and morphogenesis of the virus of hemorrhagic fever with renal syndrome (HFRS) and the associated ultrastructural changes in neurons of the infected mouse brain were examined by electron microscopy. The primary location of the infection in large neurons was in the Golgi apparatus, which had highly proliferated laminar and vesicular profiles. A small number of matured virus particles were found later individually or in small groups within the distended Golgi cisternae and vesicles. Most of the virus particles were round, oval, or elongated and measured about 70-110 nm in diameter. A lipid bilayered viral envelope with an external fringe of surface projections could be resolved at high magnification. The maturation (budding) of the virus occurred exclusively at smooth membrane vesicles, and predominantly at membranes in, or adjacent to, Golgi cisternae. Viral inclusion bodies containing fine filamentous material were seen frequently in close proximity to sites of virus maturation. The known morphological and morphogenetic characteristics of the virus particles observed in infected mouse brain gave further evidence for taxonomic identification of HFRS virus as a member of the family of Bunyaviridae.

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