Ultrastructural pathology of human liver in Rift Valley fever

Shraim, Mubarak Al; Eid, Refaat A.; Radad, Khaled; Saeed, Noora

doi:10.1136/bcr-2016-216054

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Acute hepatitis may complicate with prolonged blood coagulation times and may occur together with or precede fatal hemorrhages or neurologic complications. Autopsy studies and pathogenesis characterization in mouse model found evidence of liver necrosis with RVF viral antigens identified within hepatocytes and Küpffer cells, arguing for a direct virus-induced cellular necrosis [19,37,44,57,59,60]. A RVF case with a co-existing condition of cirrhosis after hepatitis B infection died as a result of gastrointestinal bleeding and hepatic encephalitis in Mayotte [28], and 4/31 (13%) severe cases described during the epidemic in Mauritania in 2015 had chronic hepatitis B [61], suggesting that patients with chronic hepatic ACUTE OR DELAYED ENCEPHALITIS day VISION DISORDERS day [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] disorders-mainly hepatitis B chronic infection-could be at higher risk of unfavorable outcome.…”

Section: Hepatic Manifestationsmentioning

confidence: 99%

The challenging management of Rift Valley Fever in humans: literature review of the clinical disease and algorithm proposal

Javelle

Lesueur

Santi

et al. 2020

Ann Clin Microbiol Antimicrob

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Rift Valley Fever (RVF) is an emerging zoonotic arbovirus with a complex cycle of transmission that makes difficult the prediction of its expansion. Recent outbreaks outside Africa have led to rediscover the human disease but it remains poorly known. The wide spectrum of acute and delayed manifestations with potential unfavorable outcome much complicate the management of suspected cases and prediction of morbidity and mortality during an outbreak. We reviewed literature data on bio-clinical characteristics and treatments of RVF human illness. We identified gaps in the field and provided a practical algorithm to assist clinicians in the cases assessment, determination of setting of care and prolonged follow-up.

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Section: Hepatic Manifestationsmentioning

confidence: 99%

The challenging management of Rift Valley Fever in humans: literature review of the clinical disease and algorithm proposal

Javelle

Lesueur

Santi

et al. 2020

Ann Clin Microbiol Antimicrob

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The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice

et al. 2021

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Rift Valley fever (RVF) is an emerging viral zoonosis that primarily affects ruminants and humans. We have previously shown that wild-derived MBT/Pas mice are highly susceptible to RVF virus and that part of this phenotype is controlled by a locus located on distal Chromosome 11. Using congenic strains, we narrowed down the critical interval to a 530 kb region containing five protein-coding genes among which Rnf213 emerged as a potential candidate. We generated Rnf213-deficient mice by CRISPR/CAS9 on the C57BL/6J background and showed that they were significantly more susceptible to RVF than control mice, with an average survival time post-infection reduced from 7 to 4 days. The human RNF213 gene had been associated with the cerebrovascular Moyamoya disease (MMD or MYMY) but the inactivation of this gene in the mouse resulted only in mild anomalies of the neovascularization. This study provides the first evidence that the Rnf213 gene may also impact the resistance to infectious diseases such as RVF.

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Novel Multifaceted Roles for RNF213 Protein

Pollaci

Gorla

Potenza

et al. 2022

IJMS

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Ring Finger Protein 213 (RNF213), also known as Mysterin, is the major susceptibility factor for Moyamoya Arteriopathy (MA), a progressive cerebrovascular disorder that often leads to brain stroke in adults and children. Although several rare RNF213 polymorphisms have been reported, no major susceptibility variant has been identified to date in Caucasian patients, thus frustrating the attempts to identify putative therapeutic targets for MA treatment. For these reasons, the investigation of novel biochemical functions, substrates and unknown partners of RNF213 will help to unravel the pathogenic mechanisms of MA and will facilitate variant interpretations in a diagnostic context in the future. The aim of the present review is to discuss novel perspectives regarding emerging RNF213 roles in light of recent literature updates and dissect their relevance for understanding MA and for the design of future research studies. Since its identification, RNF213 involvement in angiogenesis and vasculogenesis has strengthened, together with its role in inflammatory signals and proliferation pathways. Most recent studies have been increasingly focused on its relevance in antimicrobial activity and lipid metabolism, highlighting new intriguing perspectives. The last area could suggest the main role of RNF213 in the proteasome pathway, thus reinforcing the hypotheses already previously formulated that depict the protein as an important regulator of the stability of client proteins involved in angiogenesis. We believe that the novel evidence reviewed here may contribute to untangling the complex and still obscure pathogenesis of MA that is reflected in the lack of therapies able to slow down or halt disease progression and severity.

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Ultrastructural pathology of human liver in Rift Valley fever

Cited by 3 publications

References 24 publications

The challenging management of Rift Valley Fever in humans: literature review of the clinical disease and algorithm proposal

The challenging management of Rift Valley Fever in humans: literature review of the clinical disease and algorithm proposal

The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice

Novel Multifaceted Roles for RNF213 Protein

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