Rice-induced enterocolitis in an infant: TH1/TH2 cellular hypersensitivity and absent IgE reactivity

Gray, Heather C.; Foy, Thomas M.; Becker, Bradley A.; Knutsen, Alan P.

doi:10.1016/s1081-1206(10)61270-7

Cited by 30 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From previous studies, it was suggested that the immune response in this phenomena is primarily a TH1/TH2 cell mediated. An elevation of the cytokines IFN‐ γ , interleukin 10 (IL‐10), tumour necrosis factor‐α and IL‐5 was found in the blood of individuals after exposure to the offending food (7). In an interesting case report, a challenge with rice that caused gastrointestinal as well as systemic symptoms induced an increase in IL‐4 and a decrease in IFN‐ γ expression in peripheral T cells, suggesting that an acute FPIES reaction is associated with a Th2 skewing of the T cells cytokine profile (8).…”

Section: Discussionmentioning

confidence: 99%

The pendulum between food protein–induced enterocolitis syndrome and IgE‐mediated milk allergy

Kessel

Dalal

2011

Acta Paediatrica

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The pendulum between food protein–induced enterocolitis syndrome and IgE‐mediated milk allergy

Kessel

Dalal

2011

Acta Paediatrica

View full text Add to dashboard Cite

show abstract

“…The non-IgE-mediated allergic reactions represent the minority of immunologic responses to environmental and food allergens. They are caused by T-cell and eosinophil activation, and they develop in the absence of demonstrable allergen-specific IgE antibodies in the skin or serum [36,39,40]. …”

Section: Atopymentioning

confidence: 99%

The importance of TSLP in allergic disease and its role as a potential therapeutic target

Cianferoni¹,

Spergel

2014

Expert Review of Clinical Immunology

168

116

View full text Add to dashboard Cite

Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine similar to IL- 7, whose gene is located on chromosome 5q22.1 and it exerts its biological function through the TSLP-Receptor (TSLP-R). TSLP is expressed primarily by epithelial cells at barrier surfaces such as the skin, gut and lung in response to danger signals. Since it was cloned in 1994, there has been accumulating evidence that TSLP is crucial for the maturation of antigen presenting cells and hematopoietic cells. TSLP genetic variants and its dysregulated expression have been linked to atopic diseases such as atopic dermatitis, asthma, allergic rhinitis and eosinophilic esophagitis.

show abstract

“…Majority of the immuno‐modulatory curative approaches to food allergy operate on the basis of immunoregulating the Th1/Th2 balance. Th1 and Th2 balance are primarily maintained by the regulatory cytokines such as IL‐10 and IL‐12 (9, 10).…”

mentioning

confidence: 99%

Engineered recombinant ovomucoid third domain can desensitize Balb/c mice of egg allergy

Rupa

Mine

2006

Allergy

View full text Add to dashboard Cite

The purpose of this study was to determine the in vivo desensitization efficacy of a hypoallergenic variant of egg white ovomucoid third domain (DIII) in Balb/c mice model. We mapped the immunodominant B-cell epitopes of ovomucoid in Balb/c mice. A hypoallergenic ovomucoid third domain (GMFA) mutant isoform having ablated allergenicity against egg allergic patient's sera was used to desensitize DIII-sensitized Balb/c mice by intraperitoneal injections. Ovomucoid DIII generated high levels of plasma histamine and specific immunoglobulin (Ig)E levels, and increased Th2 type cytokine (IL-4). On the other hand, the allergic response of mice desensitized with the GMFA was found to be significantly inhibited and abrogated by prevention of anaphylaxis reactions, low histamine levels and increased Th1-type cytokine (INF-gamma). It was found that significantly higher levels of IL-10 and IL-12 were secreted in the desensitized group. Desensitization with the GMFA antigen also suppressed synthesis of DIII specific-IgE levels and enhanced specific IgG2a and IgG levels compared with the group treated with the DIII antigen. The present results indicated that hyposensitization with the GMFA can desensitize or down-regulate the allergic response in Balb/c mice and this hypoallergenic variant of ovomucoid DIII can shift an ongoing allergen-specific Th2 response towards a Th1 skewed response.

show abstract

Rice-induced enterocolitis in an infant: TH1/TH2 cellular hypersensitivity and absent IgE reactivity

Cited by 30 publications

References 21 publications

The pendulum between food protein–induced enterocolitis syndrome and IgE‐mediated milk allergy

The pendulum between food protein–induced enterocolitis syndrome and IgE‐mediated milk allergy

The importance of TSLP in allergic disease and its role as a potential therapeutic target

Engineered recombinant ovomucoid third domain can desensitize Balb/c mice of egg allergy

Contact Info

Product

Resources

About