The importance of TSLP in allergic disease and its role as a potential therapeutic target

Cianferoni, Antonella; Spergel, Jonathan M.

doi:10.1586/1744666x.2014.967684

Cited by 169 publications

(136 citation statements)

References 143 publications

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“…In this sense, a high level of IL-13 in asthmatic patients has been involved in wall remodeling processes [76,77]. Moreover, some genetic variants of TSLP have been linked to asthma or allergic rhinitis [78]. The altered genes that appeared in exposed individuals have been implicated in pulmonary effects driven by environmental agents such as viruses, cigarette smoke, oxidants, and air pollution [79][80][81], explaining, in part, the higher susceptibility of these patients to the action of airborne insults (see below).…”

Section: Airway Epithelium As a Key Player In Orchestrating The Allermentioning

confidence: 99%

Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy

López-Rodríguez

Benedé

Barderas

et al. 2017

J Investig Allergol Clin Immunol

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Airway epithelium is the cellular structure with the greatest surface exposed to a plethora of environmental airborne substances, including microorganisms, respiratory viruses, air pollutants, and allergens. In addition to being a protective physical barrier at the air-liquid interface, the airway epithelium acts as an effective chemical and immunological barrier that plays a crucial role in orchestrating the immune response in the lungs, by supporting the activation, recruitment, and mobilization of immune cells. Airway epithelium dysfunction has been clearly associated with various airway inflammatory diseases, such as allergic asthma. Although it is not fully understood why a person develops respiratory allergy, a growing body of evidence shows that the nature of the host's immune response is strongly determined by the state of the airway epithelium at the time of contact with the inhaled allergen. Our review highlights the physiological state of airway epithelium as a key element in the development of allergy and, particularly, in exacerbation of asthma. We review the role of physiological oxidants as signaling molecules in lung biology and allergic diseases and examine how high exposure to air pollutants (eg, cigarette smoke and diesel particles) can contribute to the increased incidence of respiratory allergy and exacerbation of the disease. Key words: Airway epithelium. Barrier dysfunction. Respiratory allergy. Redox biology. Air pollutants. ResumenEl epitelio pulmonar constituye la barrera celular más susceptible a la acción deletérea de la multitud de agentes que se encuentran en el ambiente, incluidos los alérgenos. Además de prevenir su acceso al organismo, la barrera epitelial de las vías respiratorias juega un papel inmunomodulador crucial, regulando de forma local la acción de las células del sistema inmune subyacentes. Una disfunción epitelial, provocada tanto directa como indirectamente por la acción de los aeroalérgenos, parece ser una de las causas principales de desregulación de la homeostasis pulmonar, causando una respuesta proinflamatoria descontrolada que cada vez más autores atribuyen al origen de las reacciones alérgicas. En esta revisión se quiere destacar el papel de la barrera epitelial pulmonar como regulador de la respuesta inmune en el contexto de la alergia. Las enfermedades crónicas que afectan a las vías respiratorias, tales como el asma alérgica, muestran frecuentemente una función epitelial defectuosa, apoyando así la hipótesis antes mencionada que subyace al origen de la alergia. El impacto de otros contaminantes ambientales -como virus respiratorios, bacterias, humo del tabaco y partículas diésel-sobre la integridad epitelial, así como su influencia en la biología redox pulmonar relacionada con el desarrollo de la respuesta alérgica, también se abordarán en la presente revisión.

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Section: Airway Epithelium As a Key Player In Orchestrating The Allermentioning

confidence: 99%

Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy

López-Rodríguez

Benedé

Barderas

et al. 2017

J Investig Allergol Clin Immunol

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“…It is now well recognized that epithelial-derived mediators such as TLSP and IL-33 are critically involved in the development and chronicity of allergic airway disease. [5][6][7] In COPD airway, inflammation is mainly induced by inhaled cigarette smoke or other noxious particles. The pathological changes are found in the airways, lung parenchyma, and pulmonary vasculature.…”

mentioning

confidence: 99%

Take the Wnt out of the inflammatory sails: modulatory effects of Wnt in airway diseases

Reuter

Beckert

Taube

2016

Laboratory Investigation

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Bronchial asthma and chronic obstructive pulmonary disease (COPD) are chronic diseases that are associated with inflammation and structural changes in the airways and lungs. Recent findings have implicated Wnt pathways in critically regulating inflammatory responses, especially in asthma. Furthermore, canonical and noncanonical Wnt pathways are involved in structural changes such as airway remodeling, goblet cell metaplasia, and airway smooth muscle (ASM) proliferation. In COPD, Wnt pathways are not only associated with structural changes in the airways but also involved in the development of emphysema. The present review summarizes the role and function of the canonical and noncanonical Wnt pathway with regard to airway inflammation and structural changes in asthma and COPD. Further identification of the role and function of different Wnt molecules and pathways could help to develop novel therapeutic options for these diseases.

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“…TSLP is overexpressed in the skin stratum corneum, and its expression correlates with the severity of the AD index score and epidermal barrier function, such as stratum corneum hydration and transepidermal water loss [12]. In fact, TSLP appears to be a key cytokine for the progression of the atopic march (atopic dermatitis to asthma), and treatment with anti-TSLP compounds is expected to have important clinical effects [13]. Our study showed that heat-killed S. aureus (HKSA) increased both mRNA and protein expression of TSLP and proinflammatory cytokine IL-6, which is consistent with the clinical finding that AD aggravation can be caused by S. aureus.…”

Section: Discussionmentioning

confidence: 99%

295 Epidermal growth factor relieves inflammatory signals in Staphylococcus aureus treated human epidermal keratinocytes and atopic dermatitis-like skin lesions in Nc/Nga mice

Lee

Choi

Kang

et al. 2017

Journal of Investigative Dermatology

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Atopic dermatitis (AD) is a chronic inflammatory skin disease with a defective immunologic barrier, which is aggravated by Staphylococcus aureus (S. aureus). Epidermal growth factor (EGF) suppresses inflammation and EGF receptor inhibitors increased S. aureus colonization. Thus, we investigated the potential roles of EGF in AD, which is often aggravated by S. aureus. We determined how EGF affects the expression of inflammatory cytokines and antimicrobial peptides (AMPs) in human epidermal keratinocytes (HEKs) treated with heat-inactivated S. aureus (HKSA) in vitro and 2,4-dinitrochlorobenzene-induced AD-like skin lesions in Nc/Nga mice. HKSA increased IL-6 and NF B expression; EGF treatment had the opposite effect. EGF increased human defensin-2 expression in HEKs and murine defensin-3 in mice. In mice, both EGF and pimecrolimus groups showed less erythema with significantly reduced inflammation and decreased expression of thymic stromal lymphopoietin. EGF relieved S. aureus-induced inflammation and AD-like skin lesions in Nc/Nga mice. Therefore, EGF could be a potential topical treatment for AD.

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The importance of TSLP in allergic disease and its role as a potential therapeutic target

Cited by 169 publications

References 143 publications

Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy

Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy

Take the Wnt out of the inflammatory sails: modulatory effects of Wnt in airway diseases

295 Epidermal growth factor relieves inflammatory signals in Staphylococcus aureus treated human epidermal keratinocytes and atopic dermatitis-like skin lesions in Nc/Nga mice

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