Rhinovirus Infections in an Industrial Population: V. Change in Distribution of Serotypes1

Abstract

Rhinovirus infections in an industrial population. V. Change in distribution of serotypes. Am J Epidemiol 99: 58-64, 1974.-During a longitudinal study of rhinovirus infections in a population of insurance company employees, the distribution of serotypes changed. Antisera prepared against 89 rhinovirus serotypes and one subtype were used in combinatorial pools with a microtitration neutralization test. Two hundred sixty-five (79%) of the 337 strains isolated from March 1963 to September 1967 were represented by types 1A through 55. 49 (14%) by types 56 through 89, and 23 (7%) were untyped. In comparison, from August 1969 to March 1970 39 (49%) of 80 strains were represented by types 1A through 55. 19 (24%) by types 56 through 89, and 22 (27%) were untyped. These data suggest either that there is a very large number of antigenically stable rhinoviruses in existence or that previously recognized types have undergone changes in their antigenic composition and emerged as apparent new types. The latter possibility has some support from studies of other investigators which show antigenic variations among strains of the same rhinovirus type. Surveillance must be continued to obtain the final answer to this question.

Studies of the Community and Family: Acute Respiratory Illness and Infection

“…As a result, it was clear that, while there were common types, they varied sufficiently from year to year to be of little help in prioritization. However, it was also clear that when sufficient antisera were used, essentially all rhinoviruses could be typed, thus putting an end to speculation regarding an endless array of types (75). However, it should be remembered that approximately 100 different antisera were required in order to draw this conclusion.…”

Respiratory tract infections due to different rhinovirus serotypes and the influence of maternal antibodies on the clinical expression of the disease in infants

“…Gener- I n m Monto and Cavallaro, 1972;Gwaltney, 19751. This is also true for those isolates marked with "X", which are untypable by standard neutralization tests and most probably represent "new" antigenic variants, a problem which is encountered in all epidemiological studies dealing with RHV-isolates [Monto and Cavallaro, 1972;Calhoun et al, 1974;Fox et al, 1975;Gwaltney, 1975;Reed, 19811. Obviously the relation between an infecting RHVserotype and the clinical expression of the disease is not strong enough to reveal statistically significant results in a study population of 49 patients. In addition, it has to be taken into consideration that differences in the ence of type-specific neutralizing antibodies of maternal origin represent an additional factor influencing the clinical expression of RHV-caused infections in infants.…”

Coronaviruses

“…(57) Two strains that are essentially identical, OC38 and OC43, have been adapted to suckling mouse brain and to primary monkey-kidney and BS-C-1 cell cultures. (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)37) Another cell system, L132, a heteroploid human lung line, has been reported to be suitable for primary isolation of 229E, a related virus (LP), and the B814, the first-described organ-culture agent. (6,9) This last finding has not been comfirmed by other workers.…”

“…This situation is unlike that seen with the rhinoviruses, in which cycling has been more difficult to demonstrate, in part because of the large number of serotypes. (14) 5.4. Age All age groups are involved in infection with OC43 virus.…”