Revisiting the ancient concept of botanical therapeutics

Schmidt, Brigitte F.; Ribnicky, David M.; Lipsky, Peter E.; Raskin, Ilya

doi:10.1038/nchembio0707-360

Cited by 298 publications

(225 citation statements)

References 29 publications

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“…One potential advantage of TOM is that the presence of multiple active ingredients or compounds in any one product presents the opportunity to affect multiple targets 5 . Ma et al 25 previously reported 24 verified combinations of TOM compounds, for which mechanisms of action are known.…”

Section: Synergistic Combinationsmentioning

confidence: 99%

“…This suggests that the search for TOM-derived compounds with the potential for multitargeting should reach beyond the commercially available natural products. Natural evolution and the greater pool of compounds present in TOMs might have contributed to their similarities with human metabolites being greater than those observed for approved drugs 5,18 . Another explanation is that approved drugs usually go through…”

Section: Synergistic Combinationsmentioning

confidence: 99%

“…Considering that the human body is a complex interacting system of many networks at the level of cells, tissues, organs and whole body, Western medicine is increasingly embracing polypharmacology as a complement to the traditional approach of using a single active ingredient or component to address a single target 3,4 . Thus, multicomponent, multitarget approaches are of interest as potential means of treating complex diseases caused by abnormal interactions among multiple molecules and pathways in a biological system [5][6][7] . A notable example from TOM is the Realgar-Indigo naturalis formula, in which the major components tetraarsenic tetrasulfide, indirubin and tanshinone IIA generate synergies by intervening in distinct T he majority of modern drugs contain a single active ingredient or component developed around a proof-of-concept test of their activity against a single biological target.…”

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confidence: 99%

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A systems approach to traditional oriental medicine

et al. 2015

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Section: Synergistic Combinationsmentioning

confidence: 99%

Section: Synergistic Combinationsmentioning

confidence: 99%

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confidence: 99%

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A systems approach to traditional oriental medicine

et al. 2015

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“…In many of the Asian countries, the tradition of utilizing botanicals has a long history [10] and a vision to develop biobased business strategies is one of the main streams of economic development [11,12]. Despite the long history of pyrolysis use, only a limited number of review articles focused on pyrolysis liquids as pesticides or biocides were found.…”

Section: Introductionmentioning

confidence: 99%

History and Use of Wood Pyrolysis Liquids as Biocide and Plant Protection Product

Tiilikkala¹,

Fagernäs²,

Tiilikkala³

2010

TOASJ

148

107

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Archeological studies have found that pyrolysis liquids were already used in the time of the Neanderthal. Wood vinegar and other slow pyrolysis liquids are produced as a by-product of charcoal production. However, future business ideas may be the other way round as pyrolysis liquids may replace synthetic chemicals in the form of pesticides and biocides.Directives and regulations related to the sustainable use of pesticides govern and direct plant protection strategies towards a lower use of synthetic chemicals. It is hoped that many mega trends of global policies will boost the use of plant based products given that a reduced reliance on fossil fuel is a general target in the global food and feed production economy. Pyrolysis technology has been actively studied and developed around the world and is linked to the development of the knowledge based bio-economy. The importance and social impact of pyrolysis technologies will also be enhanced because it is a practicable technique in the sustainable use of wastes and biomasses. However, very little scientific evidence is available to support efficacy claims of wood vinegar and toxicology assessments of the products used. Wood tar has been investigated a bit more thoroughly. The aim of this review was to clarify the potential of slow pyrolysis liquids in agricultural use, in particular, in pesticide applications. In addition, some of the main challenges in developing novel bio control technologies are discussed and the barriers in the commercialization of biological control agents are revealed.

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“…A number of natural compounds from oriental herbs and plants have been isolated for the treatment of diverse human diseases (1)(2)(3)(4)(5). In particular, a variety of Iris species are potent anti-cancer agents (6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

An ethanol extract of Iris nertschinskia induces p53-dependent apoptosis in the MCF7 human breast cancer cell line

Shin

Hong²,

Lee³

et al. 2011

Int J Mol Med

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Abstract.Iris nertschinskia, an ornamental plant, is utilized in traditional East Asian medicine for the treatment of skin diseases. However, the biological activity underlying its therapeutic effects remains to be established. In this study, we investigated the anti-tumor effect of the plant extract on McF7 human breast cancer cells. An ethanol extract of Iris nertschinskia triggered cell death in a dose-dependent manner. Moreover, treatment with the extract promoted p53 phosphorylation in McF7 cells. Increased phosphorylation of p53, in turn, led to induction of Bax protein, a key regulator of p53-dependent apoptotic cell death, as well as of caspase-7 cleavage in McF7 cells. consistently, cells treated with p53-specific siRNA or the caspase inhibitor, Z-VAD, resisted apoptotic cell death induced by the Iris nertschinskia extract. Our results suggest that p53 sensitizes tumor cells to the ethanol extract of Iris nertschinskia by Bax protein induction and caspase-dependent apoptosis.

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Revisiting the ancient concept of botanical therapeutics

Cited by 298 publications

References 29 publications

A systems approach to traditional oriental medicine

A systems approach to traditional oriental medicine

History and Use of Wood Pyrolysis Liquids as Biocide and Plant Protection Product

An ethanol extract of Iris nertschinskia induces p53-dependent apoptosis in the MCF7 human breast cancer cell line

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