An ethanol extract of Iris nertschinskia induces p53-dependent apoptosis in the MCF7 human breast cancer cell line

Shin, Jae‐Sik; Hong, Seung-Woo; Lee, Jin-Gyun; Lee, Young-Min; Kim, Dae‐Won; Kim, Jee‐Eun; Jung, Da-Jung; An, Sung-Kwan; Hong, Nam Joo; Kim, Daejin; Jin, Dong-Hoon; Lee, Sok-Young

doi:10.3892/ijmm.2011.599

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…Due to the lack of information available on phytochemistry and pharmacology about the new genera, we focus our research on understanding the activity described in this article within the traditional concept and scientific knowledge of Iris as a monophyletic genus. Other species of Iris and its related genus have previously been studied by other authors [ 36 , 38 , 39 , 40 , 41 , 42 , 43 ]. For example, extracts from the rhizome of the Iris species ( I. crocea Jacquem.…”

Section: Resultsmentioning

confidence: 99%

“…[ Xiphion orientale Schrank], I. pseudopumila Tineo, I. spuria L. [ Xiphion spurium Alef. ], and I. variegata L) have shown cytotoxic activity against various cancer cell lines, such as breast cancer (MCF7, MDA-MB-231), colon cancer (Caco-2, HCT116), cervical adenocarcinoma (Hela), melanoma (C32, IGR39), renal carcinoma (ACHN), and lung cancer (A549, CORL-23) [ 38 , 39 , 40 , 41 ]. One of the most famous plants of the Iridaceae family is Crocus sativus L. Saffron, the most expensive spice, which is obtained from the dried stigma of this plant and exhibits several pharmacological effects, including anticancer activity [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells

Jiménez-González,

Benítez,

Pastor

et al. 2023

Plants

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Every year, cancer kills millions of people around the world. Finding more selective anticancer agents is essential to improve the low survival rates of patients with metastatic cancers. Since the research of natural products is a valuable approach to the discovery of new compounds and the Iberian flora offers a rich source of unstudied plants, we have carried out a random screening of 76 plant species from 43 families collected in Andalusia (South of Spain). Using non-malignant cells (HaCaT) and lung cancer cells (A549), we found that the extract from Arum italicum Mill. subsp. italicum (Araceae), Mandragora autumnalis Bertol. (Solanaceae), Rhamnus alaternus L. (Rhamnaceae), and Lomelosia simplex (Desf.) Raf. subsp. dentata (Jord. & Fourr.) Greuter & Burdet (Dipsacaceae) showed selective cytotoxicity against lung cancer cells. Extracts of plant species belonging to the Iridaceae family showed high selective activity against cancer cells, highlighting that the Xiphion xiphium (L.) M.B. Crespo, Mart.-Azorín & Mavrodiev flower extract was more selective against lung cancer cells than the standard anticancer drugs, cisplatin and 5-fluorouracil. This extract also showed modest selective cytotoxicity against bladder carcinoma cells (T24). The number of cells in the G1 phase increased after treatment with the extract from Xiphion xiphium. Our research indicates that various plants are potential sources for the isolation and development of new anticancer drugs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells

Jiménez-González,

Benítez,

Pastor

et al. 2023

Plants

View full text Add to dashboard Cite

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Phytochemical Contents and Antioxidant Capacity of the Leaves of Aloe greatheadii var. davyana from Four South African Provinces

2019

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The current study was aimed at the determination of the phytochemical contents and antioxidant capacity of the leaves of A. greatheadii from four provinces of South Africa. The leaves samples of A. greatheadii were collected at four different locations in South Africa; namely, Limpopo province (Polokwane), Gauteng province (Ga-Rankuwa), Mpumalanga province (Siyabuswa) and North-West province (Brits) during the summer season of the year. The ground samples were then extracted in a serial sequential procedure with different organic solvents using cold maceration extraction method. The extracts were then subjected to quantitative phytochemical analysis for the determination of total phenolic, total tannin, total flavonoid and total saponin content. In addition, the antioxidant capacity of the methanol extracts were evaluated through the DPPH assay. Quantitative phytochemical analysis showed variation in the total phenolic, total tannin, total flavonoid and total saponin contents of the samples from different locations, with specific phytochemicals found in higher amounts at different locations. However, upon calculation of the total phytochemical content the high amount was recorded with the Limpopo province sample. Variation in the antioxidant capacity (EC50 based) of the samples from different locations was demonstrated, with the Limpopo and Mpumalanga provinces’ samples showing high capacity. The results demonstrated that the variation in geographical locations has an effect on the phytochemical contents and antioxidant capacity of the leaves of A. greatheadii. Furthermore, the Limpopo province area with a high altitude appeared to be providing suitable growing conditions for high accumulation of phytochemicals and higher antioxidant capacity.

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Exploring the Use of Iris Species: Antioxidant Properties, Phytochemistry, Medicinal and Industrial Applications

2022

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The genus Iris from the Iridaceae family consists of more than 262 recognized species. It is an ornamental and medicinal plant widely distributed in the Northern Hemisphere. Iris species convey a long history as valuable traditional drugs with a wide variety of applications in various cultures, having been recorded since medieval times. Currently, Iris spp. still find application in numerous fields, including cosmetics, pharmaceutics and the food industry. Moreover, many of their empirical uses have been validated by in vitro and in vivo studies, showing that Iris spp. exhibit potent antioxidant, anticancer, anti-inflammatory, hepatoprotective, neuroprotective and anti-microbial properties. Phytochemicals investigations have revealed that the plant extracts are rich in phenolic compounds, especially flavonoids and phenolic acids. As such, they constitute a promising lead for seeking new drugs with high susceptibilities towards various health issues, particularly oxidative-stress-related diseases such as cancers, neurodegenerative diseases, cardiovascular diseases, diabetes, etc. Herein, we present a literature review of the genus Iris intending to determine the plant’s chemical profile and establish a coherent overview of the biological applications of the plant extracts with reference to their traditional uses.

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An ethanol extract of Iris nertschinskia induces p53-dependent apoptosis in the MCF7 human breast cancer cell line

Cited by 4 publications

References 19 publications

Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells

Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells

Phytochemical Contents and Antioxidant Capacity of the Leaves of Aloe greatheadii var. davyana from Four South African Provinces

Exploring the Use of Iris Species: Antioxidant Properties, Phytochemistry, Medicinal and Industrial Applications

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