Review of methodology for the determination of macrocyclic lactone residues in biological matrices

Danaher, Martin; Howells, Laurence; Crooks, Steven R. H.; Cerkvenik-Flajs, Vesna; O’Keeffe, Michael

doi:10.1016/j.jchromb.2006.07.035

Cited by 122 publications

(95 citation statements)

References 135 publications

(286 reference statements)

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“…Drugs, other than those listed in this legislation, are not licensed for use in food-producing animals and therefore their residues ought not to be present in food. The occurrence and determination of benzimidazole and macrocyclic lactone residues in biological matrices have recently been reviewed by Danaher et al (2006;. Food safety and the exposure of the consumer to chemical residues in food are of continuing concern and there is an ongoing need for new analytical techniques and information on the occurrence of potentially harmful residues of veterinary drugs in our food.…”

mentioning

confidence: 99%

Stability during cooking of anthelmintic veterinary drug residues in beef

Cooper

Whelan

Danaher

et al. 2011

Food Additives & Contaminants: Part A

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mentioning

confidence: 99%

Stability during cooking of anthelmintic veterinary drug residues in beef

Cooper

Whelan

Danaher

et al. 2011

Food Additives & Contaminants: Part A

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“…3 Abamectin was developed as an insecticide and acaricide for contact and stomach action and is highly effective against gastrointestinal nematodes of cattle, 4,5 but is not approved for use in dairy animals. 6 Ivermectin is derived from abamectin and consists of a mixture of two homologues: 5-O-dimethyl-22,23-dihydroavermectin B 1a and B 1b in a ratio of 80:20. 7 Ivermectin is widely used as an antihelmintic in veterinary medicine and is used to treat onchocerciasis or river blindness in humans, 6,8 but as well as for abamectin it is not approved for use in dairy animals.…”

Section: Introductionmentioning

confidence: 99%

“…6 Ivermectin is derived from abamectin and consists of a mixture of two homologues: 5-O-dimethyl-22,23-dihydroavermectin B 1a and B 1b in a ratio of 80:20. 7 Ivermectin is widely used as an antihelmintic in veterinary medicine and is used to treat onchocerciasis or river blindness in humans, 6,8 but as well as for abamectin it is not approved for use in dairy animals. 6,9 The monitoring of veterinary drugs residues is very important for controlling the safety of milk for human consumption.…”

Section: Introductionmentioning

confidence: 99%

“…7 Ivermectin is widely used as an antihelmintic in veterinary medicine and is used to treat onchocerciasis or river blindness in humans, 6,8 but as well as for abamectin it is not approved for use in dairy animals. 6,9 The monitoring of veterinary drugs residues is very important for controlling the safety of milk for human consumption. 1 Avermectins are highly lipophilic and are stored in fat tissue, which acts as a reservoir, contributing to their long-term persistence in the body.…”

Section: Introductionmentioning

confidence: 99%

“…14 In the European Union the use of abamectin in cattle producing milk for human consumption is forbidden, whereas for ivermectin no MRL is established for milk. 6,[15][16][17] The determination of veterinary drugs in milk presents some problems because the most common approaches involve total extraction of fat by liquid-liquid extraction. The main drawbacks of this procedure are: the demanded amount of solvents and glassware, the number of step manual operations involved and the necessity of centrifugation after each extraction.…”

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confidence: 99%

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Rapid and accurate simultaneous determination of abamectin and ivermectin in bovine milk by high performance liquid chromatography with fluorescence detection

Kolberg¹,

Presta²,

Wickert³

et al. 2009

J. Braz. Chem. Soc.

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Um método analítico empregando cromatografia líquida de alta eficiência com detecção por fluorescência para a determinação simultânea de abamectin e ivermectin em leite bovino foi desenvolvido e validado. Os melhores resultados de recuperação foram obtidos empregando acetonitrila na extração dos compostos, com purificação do extrato por extração em fase sólida em cartuchos contendo C 18 . A derivação pré-coluna foi realizada com N-metilimidazol e anidrido trifluoracético. Os limites de detecção (LOD) do método para abamectin e ivermectin foram 0,10 e 0,14 µg L -1 e os limites de quantificação (LOQ) foram 0,18 e 0,36 µg L -1, respectivamente. As recuperações foram de 75 a 101%, com valores de RSD abaixo de 10%. Os valores de LOD e LOQ obtidos são inferiores aos limites máximos de resíduos em leite estabelecidos pelo Codex Alimentarius, União Européia e legislação brasileira.An analytical method using high performance liquid chromatography with fluorescence detection for the simultaneous determination of abamectin and ivermectin in bovine milk was developed and validated. The best recovery results were achieved by using acetonitrile for extraction of the compounds followed by solid phase extraction in cartridges containing C 18 for the purification of the extract. Pre-column derivatization was accomplished with N-methylimidazole and trifluoroacetic anhydride. The method limit of detection (LOD) values for abamectin and ivermectin were 0.10 and 0.14 µg L -1 and the limit of quantification (LOQ) values were 0.18 and 0.36 µg L -1 , respectively. The recoveries were from 75 to 101%, with RSD values lower than 10%. The LOD and LOQ values are lower than the maximum residue limits (MRLs) in milk established by Codex Alimentarius, European Union and the Brazilian legislation.

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Pesticides (New Generation) and Related Compounds, Analysis of

Picó

2009

Encyclopedia of Analytical Chemistry

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Miscellaneous pesticides and related compounds comprise substances that can neither be included in the classical chemical category of pesticides nor classified by their mode of action. They are a heterogeneous group of substances, the most representative of which are macrocyclic lactones, chloronicotinyls, tetranortriterpenoids, ammonium quaternary salts, dinitroanilines, acetamides, oximes, triazoles, and pyridine‐based molecules. The pesticides covered in this article have hardly changed in the last years. However, their analytical determination has undergone significant improvements. This article provides a well‐defined and critical compilation of the sample treatment and clean‐up procedures, as well as determination techniques applied to miscellaneous pesticides. The new approaches in sample preparation in environmental matrices, such as air, water, soil, food and biological samples, are described. Analytical techniques for characterizing these compounds, which mostly include gas chromatography (GC) and high‐performance liquid chromatography (HPLC) coupled to mass spectrometry (MS), are discussed. Both techniques have almost completely displaced other chromatographic methods. However, in the frontier between chemical and biological techniques, the development of biosensor techniques is very promising. Here, analytical methods applied to the field of real samples are also presented.

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Review of methodology for the determination of macrocyclic lactone residues in biological matrices

Cited by 122 publications

References 135 publications

Stability during cooking of anthelmintic veterinary drug residues in beef

Stability during cooking of anthelmintic veterinary drug residues in beef

Rapid and accurate simultaneous determination of abamectin and ivermectin in bovine milk by high performance liquid chromatography with fluorescence detection

Pesticides (New Generation) and Related Compounds, Analysis of

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