Retracted: Ultrasound‐triggered breast tumor sonodynamic therapy through hematoporphyrin monomethyl ether‐loaded liposome

Zhang, Yi; Ou, Yulong; Guo, Jia; Huang, Xiaojia

doi:10.1002/jbm.b.34447

Cited by 11 publications

(11 citation statements)

References 43 publications

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“…Hence, this means that a combination of ultrasound and HP-MSNs could have a better treatment effect on mice breast adenocarcinoma. In agreement with our findings, Zhang et al investigated that the therapeutic effect of encapsulated HP-SDT was better than HP or ultrasound alone (35). In addition, during a study by Hasanzadeh et al to review the effect of dual-frequency ultrasound radia-tion on nanomicellar containing doxorubicin, the SDT increased the ultrasound cavitations' efficiency (13).…”

Section: Discussionsupporting

confidence: 90%

Hematoporphyrin Is a Promising Sensitizer for Dual-Frequency Sono-photodynamic Therapy in Mice Breast Cancer

Khani¹,

Jadidi²,

Hasanzadeh³

et al. 2022

Int J Cancer Manag

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Background: The combination of sonodynamic and photodynamic therapy (SPDT) may be a new hopeful non-invasive method for cancer treatment, which incorporates a combination of low-intensity ultrasound, laser radiation, and a sensitizer agent. Objectives: This study aimed at evaluating the effects of hematoporphyrin (HP)-mediated SPDT (dual-frequency ultrasound and laser radiation) in the management of mice breast adenocarcinoma. Methods: One hundred and thirty-two female mice with implanted tumors were divided into 22 groups, including sham, laser, 4 groups of dual-frequency ultrasound/laser radiation, 8 groups of HP-mediated SPDT (2.5 and 5 mg/kg), and 8 groups of HP encapsulated in mesoporous silica nanoparticles (HP-MSNs)-mediated SPDT. The sensitizer was administered by intraperitoneal injection and after a 24-hour delay, tumor grafted mice were treated with a combination of dual-frequency ultrasound and laser light. The tumor growth factors were used to assess the treatment outcome. Results: The results indicated that HP or HP-MSNs-mediated SPDT had a delaying tumor growth effect. In the groups treated with dual-frequency ultrasound and laser radiation, the maximum tumor growth inhibition (TGI) ratio was 47.5%, while the maximum TGI ratio in the SPDT groups was 61.6%. The time of T2 and T5 in the case of HP-MSNs-mediated SPDT groups was increased compared with sham and that of HP-mediated SPDT groups (P < 0.05). The inhibition ratio on tumor growth increased in all SPDT groups at 12 days after the treatment. Analysis of experimental data demonstrates that this increase was not declined and persisted over 30 days of treatment. The results indicated that SPDT is effective in relative tumor volume when compared with the sham group (339.1 ± 161 and 1510.8 ± 160, respectively). HP or HP-MSNs-mediated SPDT groups had Grade I (low), while others had Grade III (high) malignancy in the histological study of mice breast adenocarcinoma. Conclusions: The results revealed that when sensitized by dual-frequency SPDT, hematoporphyrin (with and without MSNs), has a promising effect at delaying tumor growth on mice breast cancer. Therefore, it can be appreciated that careful selection of the sensitizer with SPDT will play an eminent role in the success of cancer therapies.

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Section: Discussionsupporting

confidence: 90%

Hematoporphyrin Is a Promising Sensitizer for Dual-Frequency Sono-photodynamic Therapy in Mice Breast Cancer

Khani¹,

Jadidi²,

Hasanzadeh³

et al. 2022

Int J Cancer Manag

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“…Encapsulation of sonosensitizers within nanoparticles can improve bioavailability and increase drug delivery to cancer cells by increasing drug solubility, facilitating accumulation via the enhanced permeability and retention effect, cell-specific targeting and on-demand ultrasound-triggered sensitizer release (a). This was exemplified by Zhang et al who demonstrated that encapsulation of HMME within liposomes allowed for ultrasound-mediated drug release (i), higher tumor accumulation of liposomal ICG versus free ICG (ii), and ultimately delayed tumor growth of liposomal HMME following the administration of SDT to MCF-7 tumor-bearing mice (iii) (adapted with permission from ref , Copyright 2019 John Wiley and Sons). Nanoparticle formulation of sonosensitizers also holds the advantage of providing alternative pathways to sonosensitization (b).…”

Section: Sonosensitizersmentioning

confidence: 99%

Activating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine

2020

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Sonodynamic therapy (SDT) is a promising therapeutic platform for minimally invasive cancer treatment in which acoustically susceptible drug agents, sonosensitizers, are activated by deep-tissue-penetrating low frequency ultrasound. Despite growing research in recent years, the field has yet to clearly elucidate broadly applicable mechanisms by which acoustic cavitation triggers sonosensitizer therapeutic activity, creating difficulties in achieving substantial and translatable therapeutic efficacy. In this review, we will critically analyze the proposed mechanisms underlying SDT and overview how nanomedicines can complement and extend these mechanisms to deliver more efficacious SDT. In doing so, we aim to highlight potential avenues toward viable implementation of SDT as a cancer therapy.

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“…[ 1 ] Owing to the unique advantages, SDT was applied against cancer, bacterial infection, and atherosclerosis. Up to now, several theories have been proposed to explain the mechanism of SDT, such as sonoluminescence, [ 2 ] cavitation effect, [ 3 ] etc.…”

Section: Methodsmentioning

confidence: 99%

Surface Wettability of Nanoparticle Modulated Sonothrombolysis

Zhang

Pan

et al. 2021

Advanced Materials

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Sonodynamic therapy (SDT) is a non‐invasive and highly penetrating treatment strategy under ultrasound irradiation. However, uncertainty in the mechanism of SDT has seriously hindered its future clinical application. Here, the mechanism of SDT enhanced by the wettability of nanoparticles is investigated. Nanoparticles can adsorb and stabilize nanobubbles in liquid, thus enhancing SDT efficiency. The stability of the nanobubbles is positively correlated with the desorption energy of the nanoparticles, which is determined by the wettability of the nanoparticles. This conclusion is verified for mesoporous silica and polystyrene nanoparticles and it is found that nanoparticles with a water contact angle of about 90° possess the largest desorption energy. To further apply this conclusion, thrombus models are constructed on rats and the experimental results demonstrate that nanoparticles with the largest desorption energy have the highest thrombolytic efficiency. It is believed that these findings will help to better understand the SDT mechanism and guide new strategies for rational design of nanoparticles adopted in SDT.

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Retracted: Ultrasound‐triggered breast tumor sonodynamic therapy through hematoporphyrin monomethyl ether‐loaded liposome

Cited by 11 publications

References 43 publications

Hematoporphyrin Is a Promising Sensitizer for Dual-Frequency Sono-photodynamic Therapy in Mice Breast Cancer

Hematoporphyrin Is a Promising Sensitizer for Dual-Frequency Sono-photodynamic Therapy in Mice Breast Cancer

Activating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine

Surface Wettability of Nanoparticle Modulated Sonothrombolysis

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