Retinoblastoma: Clinical and histopathologic features

Sang, Delia N.; Albert, Daniel M.

doi:10.1016/s0046-8177(82)80117-2

Cited by 75 publications

(31 citation statements)

References 111 publications

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“…Optic nerve spread indicating bad prognosis was noted by Sang and Albert and Dhir SP. 27,28 Optic nerve extension and calcification is noted in one of our case.…”

mentioning

confidence: 49%

Solid malignant pediatric tumors: a histopathological study

Gupta

Choudhary

Pachar

et al. 2017

Int J Contemp Pediatr

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Background: In general, the features of malignancies in children differ biologically and histologically from those of adults with respect to incidence, type of tumor, underlying familial or genetic aberration and tendency to regress spontaneously or cytodifferentiation. In recent years, identification of specific genes, oncogenes, tumor markers and other biological and pathological factors have played an important role in staging and classifying risk categorization of specific tumors as low, intermediate and high-risk lesions.Methods: This study is under taken to evaluate the incidence and morphological features of solid malignant tumors in children of fifteen years and below. The material for present study is obtained from S. P. Medical College, Bikaner and referred cases. The histopathology slides and paraffin blocks are reviewed.Results: The sections 3-5 μ thick, are cut and stained by haematoxylin and eosin in all cases and special stains like PAS, MTS, RS done where ever feasible. An analysis of 60 cases of solid malignant tumors of childhood over a period of 5years are made. The early onset and the embryonal nature of the major pediatric tumors, suggest a prenatal origin and role of genetic factors. Infections, exposure to drugs and chemicals during pregnancy are other contributory factors.Conclusions: Accurate incidence of data is important in the planning and evaluation of clinical trials. Documentation of cases, advanced diagnostic methods like IHC, cytogenetic studies and treatment modalities with close follow up is needed to achieve better statistical evaluation of the problem.

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“…Optic nerve spread indicating bad prognosis was noted by Sang and Albert and Dhir SP. 27,28 Optic nerve extension and calcification is noted in one of our case.…”

mentioning

confidence: 49%

Solid malignant pediatric tumors: a histopathological study

Gupta

Choudhary

Pachar

et al. 2017

Int J Contemp Pediatr

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“…This differs with the observation of no sex predilection in other studies. [14,17,23,24] Our patients appeared to present very late as the average age of the children at the time of diagnosis was 29 months. This is comparable to similar findings in the developing countries, [6,8,17,19] it is high when compared with the reports of western countries.…”

Section: Retinoblastomamentioning

confidence: 83%

“…This is comparable to similar findings in the developing countries, [6,8,17,19] it is high when compared with the reports of western countries. [14,23,24,25] The late presentation in our study could be due to among other causes like lack of awareness of the disease, delayed referral prompted by consultation with traditional medical practitioners and poor affordability and accessibility to available medical facilities.…”

Section: Retinoblastomamentioning

confidence: 84%

“…[6,19,20] Similarly, our present experience of Retinoblastoma accounting for 10.5% of all childhood cancer and the commonest childhood intraocular tumour corroborates findings in African series [19,20,21,22] but high when compared with developed countries where 2.4 -4% has been reported. [2,23] We reported a male to female sex ratio of 1.7:1. This differs with the observation of no sex predilection in other studies.…”

Section: Retinoblastomamentioning

confidence: 93%

“…This is at variance with findings in other studies where leucocoria and strabismus were observed. [16,17,23] This picture is attributed to delay in presentation of the patients for diagnosis and treatment. This opinion is supported by the claim that proptosis is the result of orbital involvement.…”

Section: Retinoblastomamentioning

confidence: 99%

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Retinoblastoma and Its Clinicopathological Correlation at a Tertiary Care Centre

Chandrakar¹,

C²

2017

jemds

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BACKGROUNDRetinoblastoma is the commonest childhood primary malignant intraocular neoplasm that is often characterised by spontaneous regression. They display photoreceptor differentiation. This study provides the clinical presentations and histological profiles of retinoblastoma in a tertiary care centre in Chhattisgarh State, in Central India. MATERIALS AND METHODSA retrospective study of clinically and histologically verified retinoblastoma at Pt JNM Medical College, Raipur, Chhattisgarh from January 2010 to December 2011 was undertaken. The clinical and histological features were analysed using the patient's case folder and surgical pathology records. RESULTSThere were 50 patients, 32 males and 18 females (M:F ratio 1.7:1), age range from 5½ months to 6 years with 42 eyeball tumours histologically confirmed retinoblastoma during the study period. Proptosis with chemosis was the most common clinical presentation (76.1%). Bilaterality was 15% in this study. Enucleation and Exenteration combined with chemotherapy were offered to 31 (75%) and 11(25%) patients respectively. CONCLUSIONModerately differentiated type with extensive areas of tumour necrosis was the commonest histological pattern. 27 (65%) of the patients died before completing the course of chemotherapy.

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Expression of Vascular Endothelial Growth Factor in Retinoblastoma

Areán

Orellana²,

Abourbih³

et al. 2010

Arch Ophthalmol

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To investigate the immunohistochemical expression of vascular endothelial growth factor (VEGF) and to determine its possible association with tumor differentiation status, optic nerve and/or choroidal invasion, anterior chamber invasion, vitreous seeding, and basophilic staining of the vascular walls.Methods: A retrospective study was performed to identify the expression of VEGF in 47 of 129 consecutive patients with retinoblastoma treated at the

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Retinoblastoma: Clinical and histopathologic features

Cited by 75 publications

References 111 publications

Solid malignant pediatric tumors: a histopathological study

Solid malignant pediatric tumors: a histopathological study

Retinoblastoma and Its Clinicopathological Correlation at a Tertiary Care Centre

Expression of Vascular Endothelial Growth Factor in Retinoblastoma

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