Responsive-released strategy based on lead ions-dependent DNAzyme functionalized UIO-66-NH2 for tumor marker

Tunable metal–organic frameworks assist in catalyzing DNAzymes with amplification platforms for biomedical applications

“…UiO-66-NH 2 was selected as an excellent nanocarrier for loading the electrode active material due to the ordered coordination connection between zirconium ions and 2-amino-terephzoic acid, making it easily modifiable by some biomolecules. 116 As a result, a lead ion decoded autobrain signal integrator was designed for the detailed analysis of prostate specific antigens (PSAs). Strong contacts are formed in complexes through the modification of specific functional groups at covalent junctions.…”

“…Ion-gated complexes are MOF-loaded fluorophores or drugs with metal ion reliant Dzs as the locking unit. 116,144,145 In the presence of respective metal ions, the specific nucleic acid locking unit was cleaved, resulting in the release of the payload (Fig. 6(b)-(f)).…”

“…186 The specific antibody-adsorbing electrode can bind to a magnetic bead probe, another antibody, and Dzs through an immune response to PSA. 116 In addition to the fluorescence method, chemiluminescence signals generated by luminol oxidation catalyzed by Dzs were used to provide a sensing platform for patients with severe acute respiratory syndrome. Besides, a simple and cost-efficient electrochemical biosensor was designed by combining MOF-functionalized paper and a screen-printed electrode (SPE) for portable, ultrasensitive, and quantitative determination of cancer-derived exosomes.…”

Homogeneous voltammetric sensing strategy for lead ions based on aptamer gated methylthionine chloride@UiO-66-NH2 framework as smart target-stimulated responsive nanomaterial

“…In particular lead ions (Pb 2+ ), are one of the most hazardous pollutants and present grave health concerns to human beings and the environment. [1][2][3][4] Pb 2+ can be accumulated in the human body through the skin, respiratory organs, and digestive system, inducing serious damage to the reproductive system, central nervous system and digestive system. [5][6][7] As a consequence, many organizations and countries have defined strict health regulations for Pb 2+ levels.…”