Tunable metal–organic frameworks assist in catalyzing DNAzymes with amplification platforms for biomedical applications

Abstract

Various binding modes of tunable metal organic frameworks (MOFs) and functional DNAzymes (Dzs) synergistically catalyze the emergence of abundant functional nanoplatforms.

Application of Nanomaterial-Based Sonodynamic Therapy in Tumor Therapy

“…Their surface properties may cause cellular damage or inflammatory responses. Therefore, when designing and applying MOF nanomaterials, factors such as their surface modification, solubility, and biocompatibility need to be considered to minimize their adverse effects on organisms [53]. Meanwhile, MOFs may release metal ions or organic ligands, leading to cellular damage or toxic effects [54].…”

MOF-mediated dual energy transfer nanoprobe integrated with exonuclease III amplification strategy for highly sensitive detection of DNA

“…11–15 Considering their large surface area, tunable pore sizes, significant adsorption affinity, and excellent fluorescence quenching ability, various MOF-based biosensors have been successfully designed and applied in sensing applications. 16–18 For example, Zhang et al developed an effective DNA detection fluorescence sensing platform employing the fluorescence quenching ability and differential binding of ssDNA and dsDNA by UiO-66-NH 2 . 19 Qiu et al demonstrated that aptamer sensors based on UiO-66 not only inherit the superior target recognition ability but also considerably enhance the analytical signal intensity of the sensor.…”

Porous reticular Co@Fe metal–organic gel: dual–function simulated peroxidase nanozyme for both colorimetric sensing and antibacterial applications

“…In recent years, nanozymes have become a bridge between the fields of nanotechnology and biology. 9–13 According to reports, nanozymes have the ability to regulate the level of ROS in the body, which can destroy bacterial cell membranes and reduce the emergence of drug-resistant bacteria. Therefore, nanozymes are considered to be ideal non-antibiotic antibacterial agents with certain antibacterial properties.…”