Response to Letter Regarding Article, “Habitual Coffee Consumption and Risk of Heart Failure: A Dose-Response Meta-Analysis”

Abstract

We thank Dr Palatini for his discussion of how the relationship between coffee consumption and heart failure may be impacted by the CYP1A2 gene. As we noted 1 , previous studies have shown that the CYP1A2 gene modifies the association between coffee consumption and myocardial infarction. We agree that further research is necessary to examine whether the presence of certain polymorphisms also modify the risk of developing heart failure. In our meta-analysis, we summarized the findings from 5 studies that showed only moderate between-study heterogeneity (I 2 =37.5%); only one 2 of the included studies reported an increased risk of heart failure with higher levels of coffee consumption, but it did not include adjustment for any potential confounders. It is possible that the results were consistent because all the included studies were conducted in Sweden and Finland, countries that may have a similar prevalence of allele frequencies for the CYPIA2 gene. Further work is needed to examine whether the relationship is affected by gene and environment interactions. DisclosuresNone. References

Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon‐like peptide‐1 secretion

“…Epidemiological studies and systematic reviews indicate that coffee intake is associated with a lower risk of type 2 diabetes . Coffee contains various types of phytochemicals, and among polyphenols specifically, chlorogenic acids are well known.…”

Coffee and Tea Consumption Are Inversely Associated with Mortality in a Multiethnic Urban Population1–3

“…High coffee consumption is associated with decreased mortality due to CVD (7,8,(12)(13)(14), respiratory disease (7), stroke (7,8), diabetes (7), infections (7), and inflammatory diseases (14), but inconsistent results have been observed across studies (10,(15)(16)(17)(18)(19)(20)(21)(22). A potential J-shaped relationship for CVDs has also been suggested [e.g., heart failure (23)]. The relationship with cancer mortality is particularly unclear, with a few studies failing to show an association (7,8) or showing differences in the association across gender (9,10).…”

Schokolade, Alkohol und Kaffee

“…Eine kürzlich publizierte Metaanalyse ergab ein geringeres Risiko für das Auftreten kardiovaskulärer Erkrankungen bei Personen, die 3 bis 5 Tassen Kaffee pro Tag trinken [99]. Ob Kaffee einen Einfluss auf das Risiko einer Herzinsuffizienz hat, bleibt kontrovers [100,101,102].…”