Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon‐like peptide‐1 secretion

Abstract

There is a pressing need for countermeasures against diabetes, which has increased in incidence, becoming a global issue. Glucagon-like peptide-1 (GLP-1), a molecule secreted in enteroendocrine L cells in the lower small and large intestines, is thought to be one of the most important molecular targets for the prevention and treatment of diabetes. There has been increasing interest in the possible ability of dietary factors to treat diabetes via modulating GLP-1 secretion. There is thought to be a close relationship between incretin and diet, and the purported best approach for using dietary factors to increase GLP-1 activity is promotion of secretion of endogenous GLP-1. It have been reported that nutrients as well as various non-nutrient dietary factors can function as GLP-1 secretogogues. Here, we present our findings on the GLP-1 secretion-stimulating functions of two dietary factors, curcumin and extract of edible sweet potato leaves, which contain caffeoylquinic acid derivatives. However, it is necessary to reveal in greater detail the stimulation of GLP-1 secretion by dietary factors for preventing and treating diabetes. It is desirable to clarify the exact GLP-1 secretory pathway, the effect of metabolites derived from dietary factors in gut lumen, and the relationship between incretin and meal.

Acute selective bioactivity of grape seed proanthocyanidins on enteroendocrine secretions in the gastrointestinal tract

“…They have been recently reviewed [2,3]. Even for these types of product, a complete description of their mechanisms of action is compulsory if their use is to be recommended for a target population.…”

Condensed catechins and their potential health-benefits

“…A basic di-peptide, Trp-His, also has the potential to promote glucose uptake by Ca 2 þ -CaM/AMPK activation through peptide/histidine transporter 1 (PHT1) incorporation into L6 cells . Polyphenols such as curcumin and caffeoylquinic acids are anti-hyperglycaemic compounds with an alternative mechanism of action; they improve BGL via the stimulation of insulin secretion by stimulating glucagon-like peptide-1 (GLP-1) at the intestine (Tsuda, 2015). In contrast, there was no study investigating the activities of condensed catechins or intact theasinensins (Fig.…”

Bioactive and functional properties of sour cherry juice (Prunus cerasus)

“…Two different control wells without sour cherry juice were also set, one with hydrogen peroxide and another with seawater. The viability of the nauplii study was measured every 24 h for 72 h. 12 2.5.2. Superoxide radical scavenging activity.…”