Bioactive and functional properties of sour cherry juice (Prunus cerasus)

Cásedas, Guillermo; Les, Francisco; Gómez-Serranillos, M. Pilar; Smith, Carine; López, Víctor

doi:10.1039/c6fo01295g

Cited by 48 publications

(25 citation statements)

References 33 publications

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“…53,54 A recent in vitro model has shown that anthocyanin-rich supplements significantly reduced certain types of ROS, 2,2-diphenyl-1-picrylhydrazy and superoxide radicals. 55 Anthocyaninrich blueberry extract induces a cellular upregulation of glutathione. Increases in glutathione mediate homeostatic levels of extracellular signal-regulated protein kinases that promote favorable learning and memory pathways.…”

Section: Figmentioning

confidence: 99%

Effect of Montmorency tart cherry juice on cognitive performance in older adults: a randomized controlled trial

et al. 2019

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Hypertension, inflammation and oxidative stress are important factors in the development of cognitive impairment. Our previous study demonstrated that tart cherry juice can lower systolic blood pressure (BP) and improve inflammatory and oxidative stress status in older adults. As part of our previous trial, we explored whether daily consumption of tart cherry juice would improve cognitive abilities. In this randomized controlled trial, 37 adults between the ages of 65-80 with normal cognitive function were recruited and randomly assigned to consume two cups of Montmorency tart cherry juice for 12 weeks. Subjective memory and objective cognitive performance were assessed at baseline and after the 12-week juice supplementation using a validated subjective memory questionnaire and a standardized battery of tests. Daily caloric intake and physical activity levels were assessed throughout the study period. After the intervention, participants in the tart cherry group had higher contentment with memory scores (mean difference of 2.7; 95% CI: 1.2 to 4.2; p = 0.02), lowered their scores of movement time (mean difference of −10.4; 95% CI: −13.4 to −7.5; p = 0.03) as well as performed better on the paired associates learning task (mean difference of −8.5; 95% CI: −12.5 to −4.5; p = 0.02) compared to the control group. The within-group analysis showed that the visual sustained attention ( p < 0.0001) and spatial working memory ( p = 0.06) improved after the 12-week consumption of tart cherry juice compared with corresponding baseline values. Daily tart cherry juice consumption may improve cognitive abilities. This may be through anti-oxidative and anti-inflammatory properties of tart cherry and its ability to lower BP. Further research is needed to confirm these findings.

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Section: Figmentioning

confidence: 99%

Effect of Montmorency tart cherry juice on cognitive performance in older adults: a randomized controlled trial

et al. 2019

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“…The neutralization of DPPH radicals as antioxidant method was reported the first time by Blois et al [33]. In this case, the assay was carried out according to the modifications described by Casedas et al [34]. In 96-well microplates, each well contained 150 µL of extract and 150 µL of DPPH (0.04 mg/mL methanol solution).…”

Section: Dpph Radical Scavenging Activitymentioning

confidence: 99%

“…Xanthine oxidase and xanthine as substrate are responsible for the production of superoxide radicals [36]. The effects of fern extracts on superoxide radicals generated by X/XO were evaluated by measuring the formation of the NBT (nitrotetrazolium blue chloride)-radical superoxide complex [37] using a described procedure [34]. The reaction mixture was prepared every day as a consequence of reduced stability.…”

Section: Superoxide Radicals Generated By Xanthine/xanthine Oxidase (mentioning

confidence: 99%

Evaluation of Anti-Tyrosinase and Antioxidant Properties of Four Fern Species for Potential Cosmetic Applications

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Cásedas

Les

et al. 2019

Forests

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Ferns are poorly explored species from a pharmaceutical perspective compared to other terrestrial plants. In this work, the antioxidant and tyrosinase inhibitory activities of hydrophilic and lipophilic extracts, together with total polyphenol content, were evaluated in order to explore the potential cosmetic applications of four Spanish ferns collected in the Prades Mountains (Polypodium vulgare L., Asplenium adiantum-nigrum L., Asplenium trichomanes L., and Ceterach officinarum Willd). The antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, oxygen radical absorbance capacity (ORAC) and xanthine/xanthine oxidase (X/XO) assays. The potential to avoid skin hyperpigmentation was tested by inhibiting the tyrosinase enzyme, as this causes melanin synthesis in the epidermis. All ferns were confirmed as antioxidant and anti-tyrosinase agents, but interestingly hydrophilic extracts (obtained with methanol) were more potent and effective compared to lipophilic extracts (obtained with hexane). Polypodium vulgare, Asplenium adiantum-nigrum, and Ceterach officinarum methanolic extracts performed the best as antioxidants. Polypodium vulgare methanolic extract also showed the highest activity as a tyrosinase inhibitor.

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“…Aqueous extracts prepared from several cultivars of sweet cherries inhibited the enzyme α glucosidase, which is involved in the intestinal absorption of carbohydrates [ 78 ]. Similarly, tart cherry juice and one of its main polyphenols known as chlorogenic acid inhibited enzymes α glucosidase and dipeptidyl peptidase-4 which are involved in promoting diabetes [ 79 , 80 ]. Tart cherry extract and select anthocyanins purified from it also inhibited the activity of human α amylase in vitro [ 81 ].…”

Section: Clinical Studies Involving Consumption Of Cherries and Thmentioning

confidence: 99%

A Review of the Health Benefits of Cherries

2018

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Increased oxidative stress contributes to development and progression of several human chronic inflammatory diseases. Cherries are a rich source of polyphenols and vitamin C which have anti-oxidant and anti-inflammatory properties. Our aim is to summarize results from human studies regarding health benefits of both sweet and tart cherries, including products made from them (juice, powder, concentrate, capsules); all referred to as cherries here. We found 29 (tart 20, sweet 7, unspecified 2) published human studies which examined health benefits of consuming cherries. Most of these studies were less than 2 weeks of duration (range 5 h to 3 months) and served the equivalent of 45 to 270 cherries/day (anthocyanins 55–720 mg/day) in single or split doses. Two-thirds of these studies were randomized and placebo controlled. Consumption of cherries decreased markers for oxidative stress in 8/10 studies; inflammation in 11/16; exercise-induced muscle soreness and loss of strength in 8/9; blood pressure in 5/7; arthritis in 5/5, and improved sleep in 4/4. Cherries also decreased hemoglobin A1C (HbA1C), Very-low-density lipoprotein (VLDL) and triglycerides/high-density lipoprotein (TG/HDL) in diabetic women, and VLDL and TG/HDL in obese participants. These results suggest that consumption of sweet or tart cherries can promote health by preventing or decreasing oxidative stress and inflammation.

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Bioactive and functional properties of sour cherry juice (Prunus cerasus)

Cited by 48 publications

References 33 publications

Effect of Montmorency tart cherry juice on cognitive performance in older adults: a randomized controlled trial

Effect of Montmorency tart cherry juice on cognitive performance in older adults: a randomized controlled trial

Evaluation of Anti-Tyrosinase and Antioxidant Properties of Four Fern Species for Potential Cosmetic Applications

A Review of the Health Benefits of Cherries

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