Evaluation of Anti-Tyrosinase and Antioxidant Properties of Four Fern Species for Potential Cosmetic Applications

Farràs, Adrià; Cásedas, Guillermo; Les, Francisco; Terrado, E.; Mitjans, Montserrat; López, Víctor

doi:10.3390/f10020179

Cited by 26 publications

(27 citation statements)

References 52 publications

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“…The total phenol content positively correlated with the determined antioxidant capacity using ORAC assay ( Table 1 ) with the value of Pearson correlation coefficient r (28) = 0.7881; p = 0.00001. Such correlation was also reported in other studies [ 16 , 17 , 18 , 19 , 20 ]. More than half of the examined fern species displayed remarkable antioxidant capacity exceeding the antioxidant capacity of the reference compound, Trolox (>1.0 g T eqv ·g −1 DW, which equals to 4mM T eqv ·g −1 DW).…”

Section: Resultssupporting

confidence: 90%

“…The total phenol content and the antioxidant capacity of fern species was also evaluated by other authors [ 11 , 17 , 19 ]. In general, our results revealed slightly higher total phenol content and antioxidant capacity.…”

Section: Resultsmentioning

confidence: 99%

“…For example, methanolic extracts of Athyrium filix-femina , Dryopteris affinis , and D. filix-mas were reported to contain between 88.7 and 234 mg GA eqv ·g −1 DW of phenols, and their antioxidant capacity was between 320 and 1055 mg T eqv ·g −1 DW (values were again recalculated from FW with the projection of 10% DW in FW). In addition, other methanolic extracts of Asplenium trichomanes , A. caterach , Ceterach officinarum, and Polypodium vulgare were reported to contain between 100 and 193 mg GA eqv ·g −1 DW of phenols, with the antioxidant capacity being between 562 and 732 mg T eqv ·g −1 DW [ 17 ]. On the other hand, our values were between 67 and 434 mg GA eqv ·g −1 DW for phenols and between 267 and 1949 mg T eqv ·g −1 DW for the antioxidant capacity.…”

Section: Resultsmentioning

confidence: 99%

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Nutritional and Antioxidant Potential of Fiddleheads from European Ferns

Dvořáková

Pumprova

Antonínová

et al. 2021

Foods

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Ferns are part of the diet and traditional medicine in East Asia, North America, and Oceania, however, their importance has been forgotten in Europe. Here, the nutritional and antioxidant potential of young fern fronds (fiddleheads) of eight families were studied. Most of the tested fern species excelled in high antioxidant capacity when compared to the reference leafy vegetables spinach and rocket. On average, the total phenol content reached 220 mg·g−1 of extract dry weight for all fiddleheads, and 15 out of 24 tested species exceeded 1 g Trolox equivalent per gram of extract dry weight in Oxygen Radical Absorbance Capacity (ORAC) assay. On the other hand, fiddleheads contained a comparable amount of carotenoids and ascorbic acid with the reference vegetables. In the case of fatty acid composition, fiddleheads contained especially high amounts of essential omega-3 (n3) and omega-6 (n6) polyunsaturated fatty acids with a beneficial n6/n3 ratio. The n6/n3 ratio in all tested species was between 2 and 6.4, whereas the ratio in the reference vegetables was below 0.4. All in all, fiddleheads from European ferns are a rich source of valuable antioxidants and essential fatty acids with a desirable n-6/n-3 ratio and may thus form an alternative source of these compounds, especially for those people not consuming fish and fish products.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Nutritional and Antioxidant Potential of Fiddleheads from European Ferns

Dvořáková

Pumprova

Antonínová

et al. 2021

Foods

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“…The contents of polysaccharide, phenolics, triterpenoid and their antioxidant, hypolipidemic and hypoglycemic effects in C. paliurus leaves have been reported to vary with different geographical locations [13,17,18,20]. Phytochemical contents, antioxidant and anticancer activities in plant extracts also vary with extraction solvents such as water, aqueous mixtures of ethanol, ethanol and methanol [21,22]. For example, antiproliferative activity on cancer cells was found in both ethanol and aqueous extracts of Ficus beecheyana and Saururus chinensis root, however the ethanol extracts showed better antioxidant activity [23,24].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

Zhou

Chen

Lin

et al. 2019

Forests

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Cyclocarya paliurus (Batal.) Iljinskaja is an indigenous and multifunction tree species in China, but it is mainly used in pharmaceutical and nutraceutical ingredients. To make a comprehensive evaluation on its bioactive metabolites, antioxidant and antitumor potentials of C. paliurus leaves, the leaf samples were collected from 15 geographic locations (natural populations) throughout its distribution areas. High-performance liquid chromatography (HPLC) and colorimetric methods were used to detect the contents of bioactive metabolites. The antioxidant activity was evaluated by 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and reducing power assays. The antiproliferative activity on different cancer cell types was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Contents of bioactive metabolites, and antioxidant and antiproliferative activities in the extracts were significantly affected by solvent and population. In most cases, the contents of flavonoids and triterpenoids, and the antioxidant and antiproliferative activities in the ethanol extracts were higher than the water extracts. The best scavenging capacity of DPPH (IC50 = 0.34 mg/mL) and ABTS (IC50 = 0.50 mg/mL) radical occurred in the ethanol extracts of S15 and S7 population respectively, while the strongest reducing power (EC50 = 0.71 mg/mL) was achieved in the ethanol extracts of S14 population. The antiproliferation effects of C. paliurus extracts on cancer cells varied with different cell types. The HeLa cell was the most sensitive to C. paliurus extracts, and their IC50 values of the ethanol extracts varied from 0.13 to 0.42 mg/mL among C. paliurus populations. Redundancy analysis showed that total polyphenol had the greatest contribution to the antioxidant activity, but total flavonoid was mostly responsible for the antiproliferation effects. These results would provide important scientific evidences not only for developing C. paliurus as a potent antioxidant and antitumor reagent, but also for obtaining the higher yield of bioactive compounds in the C. paliurus plantation.

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“…This fact could be explained with the differences of chemical profiles in these extracts and the complex interactions of phytochemicals. However, methanolic extracts exhibited stronger actions on tyrosinase in earlier studies conducted by some researchers [36,37].…”

Section: Enzyme Inhibition Activitymentioning

confidence: 69%

Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food

Zengin

Mahomoodally

Rocchetti

et al. 2020

Foods

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Fibigia clypeata (L.) Medik. is a poorly studied plant species belonging to the Brassicaceae family, and usually used as cress in the salads. The current investigation aimed at assessing the antioxidant potential and inhibitory activity of ethyl acetate, methanol, and aqueous extracts of F. clypeata against key enzymes targeted in the management of type II diabetes (α-amylase and α-glucosidase), Alzheimer’s disease (acetylcholinesterase and butyrylcholinesterase), and skin hyperpigmentation (tyrosinase). Cytotoxicity of the extracts was also determined using normal VERO and cancer FaDu and SCC-25 cell lines. Besides, LC-MS was employed to investigate the detailed phytochemical profiles of the extracts. The methanol extract showed potent enzyme inhibitory activity (4.87 mg galantamine equivalent/g, 3.52 mg galantamine equivalent/g, 126.80 mg kojic acid equivalent/g, and 24.68 mg acarbose equivalent/g, for acetylcholinesterase, butyrylcholinesterase, tyrosinase, and α-glucosidase, respectively) and antioxidant potential (96.52, 109.10, 154.02, and 104.85 mg trolox equivalent/g, for DPPH, ABTS, CUPRAC, and FRAP assays, respectively). Interestingly, caffeic acid-O-hexoside derivative, caffeyl alcohol O-glucopyranoside, and ferulic acid derivative were identified in all extracts. F. clypeata extracts showed no cytotoxicity towards VERO cell line and a weak cytotoxic potential against FaDu and SCC-25 cell lines. Interesting scientific evidence gathered from the present study support further investigation on F. clypeata in the view of designing and developing a novel therapeutic agent for the management of Alzheimer’s disease, type II diabetes, skin hyperpigmentation problems, as well as cancer.

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Evaluation of Anti-Tyrosinase and Antioxidant Properties of Four Fern Species for Potential Cosmetic Applications

Cited by 26 publications

References 52 publications

Nutritional and Antioxidant Potential of Fiddleheads from European Ferns

Nutritional and Antioxidant Potential of Fiddleheads from European Ferns

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

Chemical Characterization and Bioactive Properties of Different Extracts from Fibigia clypeata, an Unexplored Plant Food

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