Condensed catechins and their potential health-benefits

Matsui, Toshiro

doi:10.1016/j.ejphar.2015.09.017

Cited by 55 publications

(32 citation statements)

References 76 publications

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“…Catechins are polyphenolic molecules present in various types of teas, commonly related to health benefits due to their antioxidant capacity and attenuation of NFκB activation [221][222][223][224]. Epigallocatechin-3-gallate (EGCG) is the major constituent among catechins present in tea leaves [224].…”

Section: Catechinsmentioning

confidence: 99%

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

et al. 2020

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Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a consequence of the pathological functioning of the nervous system rather than only a symptom. In fact, pain is a significant social, health, and economic burden worldwide. Flavonoids are plant derivative compounds easily found in several fruits and vegetables and consumed in the daily food intake. Flavonoids vary in terms of classes, and while structurally unique, they share a basic structure formed by three rings, known as the flavan nucleus. Structural differences can be found in the pattern of substitution in one of these rings. The hydroxyl group (-OH) position in one of the rings determines the mechanisms of action of the flavonoids and reveals a complex multifunctional activity. Flavonoids have been widely used for their antioxidant, analgesic, and anti-inflammatory effects along with safe preclinical and clinical profiles. In this review, we discuss the preclinical and clinical evidence on the analgesic and anti-inflammatory proprieties of flavonoids. We also focus on how the development of formulations containing flavonoids, along with the understanding of their structure-activity relationship, can be harnessed to identify novel flavonoid-based therapies to treat pathological pain and inflammation.

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Section: Catechinsmentioning

confidence: 99%

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

et al. 2020

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“…Through esterification with gallate groups, flavanols can form EGCG, the gallic acid ester of EGC at position 3, approximately half of total green tea catechins [ 63 ], and ECG (approximately 13.6% of total green tea catechins) [ 9 ] ( Figure 2 ).The catechins mainly comprise catechin, EC, ECG, EGC, and EGCG [ 9 , 10 ]. Monomeric catechins can further react and synthesize the condensed catechins which are produced by random polymerization [ 10 , 44 , 64 ]. Then, the chemical structures of the resulting dimeric condensed catechins are defined by not only the monomeric catechins, but also the pathway of link among monomers [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease

2017

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Catechins are natural polyphenolic phytochemicals that exist in food and medicinal plants, such as tea, legume and rubiaceae. An increasing number of studies have associated the intake of catechins-rich foods with the prevention and treatment of chronic diseases in humans, such as inflammatory bowel disease (IBD). Some studies have demonstrated that catechins could significantly inhibit the excessive oxidative stress through direct or indirect antioxidant effects and promote the activation of the antioxidative substances such as glutathione peroxidases (GPO) and glutathione (GSH), reducing the oxidative damages to the colon. In addition, catechins can also regulate the infiltration and proliferation of immune related-cells, such as neutrophils, colonic epithelial cells, macrophages, and T lymphocytes, helping reduce the inflammatory relations and provide benefits to IBD. Perhaps catechins can further inhibit the deterioration of intestinal lesions through regulating the cell gap junctions. Furthermore, catechins can exert their significant anti-inflammatory properties by regulating the activation or deactivation of inflammation-related oxidative stress-related cell signaling pathways, such as nuclear factor-kappa B (NF-κB), mitogen activated protein kinases (MAPKs), transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), signal transducer and the activator of transcription 1/3 (STAT1/3) pathways. Finally, catechins can also stabilize the structure of the gastrointestinal micro-ecological environment via promoting the proliferation of beneficial intestinal bacteria and regulating the balance of intestinal flora, so as to relieve the IBD. Furthermore, catechins may regulate the tight junctions (TJ) in the epithelium. This paper elaborates the currently known possible molecular mechanisms of catechins in favor of IBD.

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“…It has been reported that the small intestine is the organ mainly responsible for the absorption of polyphenols with low bioavailabilities. (47) Therefore, evaluating the intestinal absorption and metabolism of polyphenols is important for understanding their bioavailability and mechanism of absorption. Although a cell-based in vitro intestinal epithelial model using Caco-2 cells is commonly used, (48,49) the Caco-2 cell model exhibits several shortcomings, such as differences in protease expression from those in actual intestinal membranes.…”

Section: Maldi-ms Imaging As a Novel Methods For In Situ Visualizationmentioning

confidence: 99%

“…Thus, the inhibitor-aided MALDI-MS imaging technique is a powerful and novel analytical tool for the direct analysis of the intestinal absorption of analytes without the pretreatment steps, such as extraction and separation, required in LC and LC-MS analyses. (53) Inhibitor-aided intestinal MALDI-MS imaging has also been used to investigate the absorption of nonabsorbable theaflavin-3'-O-gallate (TF3'G), (47) which can regulate the intestinal expression of peptide transporter 1 (PepT1) and tight-junction (TJ)-related proteins (claudin-1, ZO-1, and occludin) in order to inhibit the intestinal transport of peptides and TJmediated substrates. (62,63) Interestingly, although TF3'G was not absorbed, the apical-specific localization of TF3'G on an intestinal membrane after Ussing chamber transport was clearly visualized [ Fig.…”

Section: Maldi-ms Imaging As a Novel Methods For In Situ Visualizationmentioning

confidence: 99%

Detection and Visualization of Food-derived Polyphenols by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Nguyen¹,

Ham²,

Matsui³

et al. 2019

Sensors and Materials

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Food-derived polyphenols have health benefits owing to their ability to prevent some diseases. Knowledge of their bioavailabilities and metabolism is important for understanding the mechanisms underlying their benefits. Thus, mass spectrometry (MS)-based analytical techniques, such as liquid chromatography-MS (LC-MS), that are capable of highly sensitive and simultaneous detection of absorbed polyphenols and their metabolites are essential tools in this field. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) imaging is currently used in biological sciences for visualizing the spatial information of various compounds, such as peptides, proteins, lipids, drugs, and food compounds, in various biological tissues. However, the application of MALDI-MS imaging to polyphenols is challenging owing to the lack of appropriate matrix reagents for visualizing (or detecting) polyphenols absorbed in target biological tissues. This review highlights the development of the MALDI-MS imaging technique for the detection and visualization of food-derived polyphenols. First, the development of new matrices and matrix additives for the detection and visualization of polyphenols is discussed, followed by their introduction to inhibitor-aided MALDI-MS imaging for the elucidation of intestinal absorption routes and the metabolic behaviors of polyphenols. The MALDI-MS imaging technique shows great potential as a novel analytical tool for elucidating the bioavailabilities of food-derived polyphenols.

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Condensed catechins and their potential health-benefits

Cited by 55 publications

References 76 publications

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease

Detection and Visualization of Food-derived Polyphenols by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry Imaging

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