Response Surface Methodology of Pressurized Liquid Water Extraction of Curcumin From Curcuma Domestica Val

Abstract

Curcumin, an active compounds found in Curcuma domestica Val, exhibits many pharmacological effects. Due to its numerous benefits, pressurized liquid water extraction is gaining many interests from researchers. Response Surface Methodology applied in the optimization study of the pressurized liquid water extraction of curcumin from Curcuma domestica Val. Central Composite Design was applied in the design of this research. The parameter process studied were temperature (130-150 0 C), time (20-40 minutes) and reaction volume (4-6.2 L). The solid-liquid ratio was fixed at a ratio of 1:10, ad the pressure was fixed of 2 bar. Response surface of the pressurized liquid water extraction of curcumin was expressed by a second-order polynomial. The research showed that the model we adequate to predict the pressurized liquid water extraction of curcumin in the range of variables studied in this research. The research showed that temperature was the most influencing variable for pressurized liquid water extraction of curcumin from Curcuma domestica Val. The optimal value of the pressurized liquid water extraction of curcumin was obtained by solving the second-order polynomial regression equation. The curcumin pressurized liquid water extraction was optimum at an extraction temperature of 156.81 0 , extraction time of 46.81 minutes and solvent volume of 6.95L.

Bioadsorption of Modified Empty Fruit Bunch Palm Oil for Reducing its 3-MCPD Compounds using Response Surface Methodology

“…Many researches have used Response surface methodology (RSM) in optimization of various process including in the optimization of acid hydrolysis of grasses [8], rice husk lignin extraction [9], curcumin extraction [13], fiber reinforcement [10], biodiesel production [11], and optimizing waste heat recovery from the cement plant [14]. RSM is an empirical statistical technique employed for multiple regressions analysis.…”

The Effect of Operating Conditions on Curcumin Extracted from Turmeric by Hydrothermal Extraction

“…Nevertheless, Figure 2 shows that in general, the concentration of curcumin produced on hydrothermal extraction at temperatures of 140 and 150 0 C were greater than at 130 0 C. This is due to higher temperatures, the viscosity and the water surface tension will decrease. Thus it will force the mass transfer rate and the absorption into particle matrices [16]. The data of curcumin concentration obtained from hydrothermal extraction with a solid liquid ratio 1:12, temperature 130-150 o C were presented in Figure 3.…”

“…However, with the same extraction temperature (140-150 o C), extraction at 1:10 solid liquid ratio produces higher concentration than at 1:12 solid liquid ratio. Extraction using subcritical water was done to separate polysaccharides from Lycium barbarum L [25]. The research shows that increasing ratio of 10 to 25 ml / g, causing extraction yield increases.…”

“…The using of water as a green solvent for extraction in subcritical areas will be effective if it keeps at high temperatures. Since at high temperatures, the viscosity and surface tension of the water decreases so it will drive the mass transfer rate, absorption into matrix particles and increase the selectivity [14][15][16]. The use of water in subcritical areas as green solvents has attracted the attention of researchers from all over the world.…”

Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects

“…Hence, an ideal sample preparation method should be simple, fast, and yielding maximum analyte recovery efficiently and minimum (or no) matrix interferences. Table 2 shows various sample preparation protocols used for extraction and analysis of curcuminoids from a wide array of matrices (biological-plasma and tissue, plant -rhizome and foods) as well as different formulations [13,25,26,27,28,29,31,32,33,35,36,37,38,39,130,131].…”