Reproductive Hazards of the Workplace and the Home

Wl, Heinrichs

doi:10.1097/00003081-198306000-00024

Cited by 6 publications

(3 citation statements)

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“…Earlier, Heinrichs 90) and Wang and Zhao 91) also reported an increased incidence of spontaneous abortion at a level as low as about 2 ppm (6-7 mg/m 3 ), but a community based study of spontaneous abortion, occupation and air pollution carried out by Hemminki and Niemi 92) found no relationship between the carbon disulfide concentration and miscarriage rates. However, available data provide some indication that CS 2 may affect the reproductive system of both sexes 84,87,[89][90][91] . Tielemans et al 93) found an association between exposure to aromatic solvents and reduced semen quality in a case control study.…”

Section: Occupations Involved Exposure To Toxic Solvents and Related mentioning

confidence: 99%

Occupational Exposure Associated with Reproductive Dysfunction

Kumar

2004

Journal of Occupational Health

168

114

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Section: Occupations Involved Exposure To Toxic Solvents and Related mentioning

confidence: 99%

Occupational Exposure Associated with Reproductive Dysfunction

Kumar

2004

Journal of Occupational Health

168

114

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“…Adverse effects on fetal development have not been documented in humans. Antispermatogenic effects and possible effects on fertility have been reported in humans occupationally exposed to 1,2 -dibromoethane (Wong et al, 1979;Ter Haar, 1980;Heinrichs, 1983;Ratcliffe et al, 1987 ). However, many of these studies lack sufficient statistical power to detect an association between parameters measured and exposure.…”

Section: _20 Yearsmentioning

confidence: 99%

Agency for Toxic Substances and Disease Registry's 1997 priority list of hazardous substances. Latent effects—carcinogenesis, neurotoxicology, and developmental deficits in humans and animals

et al. 1999

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In support of Superfund re-authorization legislation, the Division of Toxicology of the Agency for Toxic Substances and Disease Registry (ATSDR) prepared a chemical-specific consultation document for Congress that identified those chemicals with carcinogenic, neurological, or developmental adverse effects having a latency period longer than 6 years. The review was limited to the top 50 substances listed on ATSDR's 1997 Priority List of Hazardous Substances (Priority List). Among the top 50 chemicals, a review of the technical literature indicated that 38 (76%) were classified as "reasonably anticipated," "possibly," or "probably" capable of causing cancer in humans, based either on human and animal data. Eight chemicals (16%) had well-established cancer latency periods in humans of 6 years or more following exposure. Three substances (6%)--arsenic, creosote, and benzidine--had data indicating latency periods longer than 6 years. The technical literature review likewise confirmed the potential for neurological and developmental effects with a latency of 6 years. Twenty-seven (54%) of the top 50 substances caused acute and/or chronic neurotoxic effects; a number of these also caused neurological effects that persisted beyond 6 years (or the equivalent in animal studies) such as: behavioral problems, neurological deficiencies, reduced psychomotor development, cognitive deficiencies, and reduced IQ. Twenty-eight substances (56%) caused adverse developmental effects in offspring of exposed individuals or animals including increased fetal and infant mortality, decreased birth weights and litter sizes, and growth delays. Latency periods for related chemicals are expected to be similar due to structural and toxicological similarities.

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“…Positive associations with low birth weight have been reported for two of the metals (cadmium and lead) in animals and humans (11)(12)(13)(14). However, the real public health threat to residents living near the contamination was likely due to the VOCs because of their high evaporative qualities and, therefore, their enhanced capability for exposing more people in the community.…”

Section: 600mentioning

confidence: 99%