Agency for Toxic Substances and Disease Registry's 1997 priority list of hazardous substances. Latent effects—carcinogenesis, neurotoxicology, and developmental deficits in humans and animals

Abstract

In support of Superfund re-authorization legislation, the Division of Toxicology of the Agency for Toxic Substances and Disease Registry (ATSDR) prepared a chemical-specific consultation document for Congress that identified those chemicals with carcinogenic, neurological, or developmental adverse effects having a latency period longer than 6 years. The review was limited to the top 50 substances listed on ATSDR's 1997 Priority List of Hazardous Substances (Priority List). Among the top 50 chemicals, a review of the technical literature indicated that 38 (76%) were classified as "reasonably anticipated," "possibly," or "probably" capable of causing cancer in humans, based either on human and animal data. Eight chemicals (16%) had well-established cancer latency periods in humans of 6 years or more following exposure. Three substances (6%)--arsenic, creosote, and benzidine--had data indicating latency periods longer than 6 years. The technical literature review likewise confirmed the potential for neurological and developmental effects with a latency of 6 years. Twenty-seven (54%) of the top 50 substances caused acute and/or chronic neurotoxic effects; a number of these also caused neurological effects that persisted beyond 6 years (or the equivalent in animal studies) such as: behavioral problems, neurological deficiencies, reduced psychomotor development, cognitive deficiencies, and reduced IQ. Twenty-eight substances (56%) caused adverse developmental effects in offspring of exposed individuals or animals including increased fetal and infant mortality, decreased birth weights and litter sizes, and growth delays. Latency periods for related chemicals are expected to be similar due to structural and toxicological similarities.

Effect of Arsenic and Manganese Exposure on Intellectual Function of Children in Arsenic Stress Area of Purbasthali, Burdwan, West Bengal

“…The age group above 6 year showed very low to moderate level (Table 5). Similar results were reported by Ostrowski et al (1999). They reported that neurological deficits caused by arsenic may persist beyond 6 years.…”

“…The present study also highlighted that school children get slowly affected which is understood from the performance of their cognitive function as neurological deficits caused by arsenic. Very similar report was published by Ostrowski et al (1999). They reported that neurological deficits caused by arsenic and suspected that this arsenic might persist beyond 6 years.…”

MDI Biological Laboratory Arsenic Summit: Approaches to Limiting Human Exposure to Arsenic

“…Arsenic is the number one environmental chemical of concern with regard to human health both in the United States (U.S.) and worldwide [2, 3]. The World Health Organization (WHO) has stated that human exposure to arsenic represents a significant health problem worldwide that requires immediate attention [3,4].…”

Pancreatic cancer clusters and arsenic-contaminated drinking water wells in Florida

“…Arsenic is linked to bladder, skin, and lung cancer occurrence in populations highly exposed to arsenic occupationally, medicinally, or through exposure to contaminated drinking water [16,17]. Many of the more recent studies linking arsenic exposure to these cancer outcomes were conducted in countries outside of the US, such as Scandinavian countries [18,19], Taiwan [20-23], Argentina [24] and Chile [25].…”