Reproductive and possible hormonal effects of carbendazim

Rama, Elkiane Macedo; Bortolan, S.; Vieira, Milene Leivas; Gerardin, Daniela Cristina Ceccatto; Moreira, Estefânia Gastaldello

doi:10.1016/j.yrtph.2014.05.016

Cited by 78 publications

(36 citation statements)

References 36 publications

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“…For example, the organochlorine pesticide methoxychlor (500 and 1,500 ppm) increased uterine weight in in rats (Aoyama et al 2012; Yu et al 2013), whereas carbendazim (500 mg and 1,000 mg/kg) decreased uterine weight in rats (Rama et al 2014). Additionally, a mixture of organophosphate pesticides (dichlorovos, dimethoate, and malathion) (107.5 mg/kg) increased endometrial hyperplasia in rats (Aoyama et al 2012; Yu et al 2013).…”

Section: Pesticidesmentioning

confidence: 99%

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Rattan

Zhou

Chiang

et al. 2017

Journal of Endocrinology

258

150

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Endocrine disrupting chemicals are ubiquitous chemicals that exhibit endocrine disrupting properties in both humans and animals. Female reproduction is an important process, which is regulated by hormones and is susceptible to the effects of exposure to endocrine disrupting chemicals. Disruptions in female reproductive functions by endocrine disrupting chemicals may result in subfertility, infertility, improper hormone production, estrous and menstrual cycle abnormalities, anovulation, and early reproductive senescence. This review summarizes the effects of a variety of synthetic endocrine disrupting chemicals during adult life. The chemicals covered in this review are pesticides (organochlorines, organophosphates, carbamates, pyrethroids, and triazines), heavy metals (arsenic, lead, and mercury), diethylstilbesterol, plasticizer alternatives (di-(2-ethylhexyl) phthalate and bisphenol A alternatives), 2,3,7,8-tetrachlorodibenzo-p-dioxin, nonylphenol, polychlorinated biphenyls, triclosan, and parabens. This review focuses on the hypothalamus, pituitary, ovary, and uterus because together they regulate normal female fertility and the onset of reproductive senescence. The literature shows that several endocrine disrupting chemicals have endocrine disrupting abilities in females during adult life, causing fertility abnormalities in both humans and animals.

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Section: Pesticidesmentioning

confidence: 99%

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Rattan

Zhou

Chiang

et al. 2017

Journal of Endocrinology

258

150

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“…It was reported that excessive ROS production leads to oxidative stress and then cause DNA damage . Previous studies showed that pesticides could potentially affect the HPG axis and steroidogenic process, and induce reproductive toxicity by increasing oxidative stress . Cypermethrin could induce endocrine disruption and simultaneously increased the transcription and activities of antioxidant enzymes .…”

Section: Discussionmentioning

confidence: 99%

“…47 Previous studies showed that pesticides could potentially affect the HPG axis and steroidogenic process, and induce reproductive toxicity by increasing oxidative stress. 48 Cypermethrin could induce endocrine disruption and simultaneously increased the transcription and activities of antioxidant enzymes. 49 In current study, the ROS level was elevated after exposed to individual FEN and TDF, and ROS levels were significantly higher in rare minnow exposed to FEN and TDF binary mixtures than in the individual treatment, suggesting that FEN and TDF had the potential to synergistically induce oxidative stress in rare minnow.…”

Section: Discussionmentioning

confidence: 99%

Synergistic potential of fenvalerate and triadimefon on endocrine disruption and oxidative stress during rare minnow embryo development

Zhao

et al. 2018

Environmental Toxicology

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Pyrethroids have been reported to interact synergistically when co-exposed with azoles fungicides in different organisms. In the present study, we investigated the mixture toxicity of fenvalerate (FEN) and triadimefon (TDF) toward embryos of Gobiocypris rarus after 96 h exposure. Results demonstrated that TDF enhanced the acute toxicity of FEN. Exposure to binary mixtures of FEN and TDF resulted in synergistic responses of endocrine disruption by inducing the transcripts of several genes including vtg, erα, erβ1, erβ2, cyp19a, cyp1a, cyp4, cyp11a, gnrh3, gnrhr1a, star, and dmrt1. Furthermore, FEN and TDF mixture increased the VTG level and aromatase activity in rare minnow embryos. FEN and TDF co-exposure also regulated the mRNA of vezf, hsp70, p53, gadd45α, induced the synthesis of ROS and activity of GST, suggesting the synergistic potential of oxidative stress induced by FEN and TDF co-exposure. The results indicated that binary mixtures of FEN and TDF could simultaneously induce endocrine disruption and oxidative stress in a synergistic manner during rare minnow embryo development.

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“…За даними багатьох дослідників, такі препарати як карбендазим, беноміл, альбендазол, тіабендазол мають яскраво виражені цитогенетичну, ембріотоксичну, тератогенну і гонадотоксичну дії, впливають на білковий і вуглеводний обміни, стан ендокринної системи, а також на показники гуморального імунітету. Крім того, є окремі повідомлення про канцерогенність і мутагенність цих речовин (Barlas, Selmanoglu, Koçkaya, & Songür, 2002;Aire, 2005;Lu et al, 2004;Adedara et al, 2013;Shepel'skaya, Ivanova, Sapozhnikova, & Grigorenko, 2013;Rama et al, 2014;Durand et al, 2016;Kolyanchuk, 2018;Lu, 2018).…”

Section: вступunclassified

Teratogenic and embryotoxic influence of carbenddazim which is had on chickens’ embryons

Zhukova¹,

Kochevenko²,

Bobrytska³

et al. 2019

VTTP

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Introduction of chemical substance technologies into agriculture among which there are 300 pesticides is a guarantee of receiving a completed agricultural product for the protection of animals and plants from pests, mourning bands, ectoparasites and diseases. Despite the positive results of pesticides usage there is a negative side which lies in danger posed to animals and people health.To discover teratogenic and embryotoxic effect fungicide and seed treatment Derozal which is produced by Bayer (Germany) has been used, an active ingredient of which is carbendazim (BMK) (500g/l). It has been injected into the allantois cavity of 9-11 days old chickens' embryos of K-8 line with a mass 59-61 gr (n=100) in dose of 0.05 LD50 and 0.01 LD50 (500 and 100 mg/kg of an embryo mass relatively) (LD50 for chickens is 9089.0 mg/kg). The doses of pesticide have been calculated due to the existence of active substance (50%). The embryos of a controlled group have been injected with isotonic liquid of sodium chloride in quantity of 0.5 cm 3 . Test as well as controlled chickens' embryos have been observed daily through the ovoscope up to the moment of chickens' hatch with the aim to distinguish the coloration and liveliness, the size of air chamber, the quality of shell, the state of an embryo, its development and the blood system of allantois. Dead chickens' embryos have been removed and stored for further experiments under the temperature + 4°С.During the analyses of the influence of different doses of carbendazim it has been determined that the dose of 0.05 LD50 of the substance has caused the death of 14 (46.7 %) embryos, and dose of 0.05 LD50the death of 9 (30.0 %) chickens' embryos. The control has shown that isotonic liquid of NaСl has not caused the mass death of embryos (5 %). Teratogenic influence of carbendazim has been determined by the existence of undeveloped or complete absence of eyes, beaks, one or both limbs, non-fused abdominal cavity and fall-out of internal organs as well as combination of several deformities. The percentage of healthy embryos in the 1 st and 2 d groups has been at the level of 56.7-80.0 % relatively. Thus, the results of the carried out experiment represent that carbendazim in mentioned doses has highly marked embryotoxic influence on chickens' embryos and also has teratogenic effect.

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Reproductive and possible hormonal effects of carbendazim

Cited by 78 publications

References 36 publications

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Synergistic potential of fenvalerate and triadimefon on endocrine disruption and oxidative stress during rare minnow embryo development

Teratogenic and embryotoxic influence of carbenddazim which is had on chickens’ embryons

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