Pig breeding in Ukraine is a priority and perspective branch of agriculture to solve the problem of providing the population with the food products of high quality (meat, fat). Meat production is one of the most complicated industries in the field of agriculture. The problem of providing the population with meat is almost impossible to solve without the intensive development of the industry since pigs are different from other farm animals by the premature and high output of slaughter products. The article presents the data of the research on the state of the antioxidant system of pigs when using Macleay and the additives of raw buckwheat «buckwheat green» as the source of quercetin to the feeds. As a result of the experiment it has been found out that the addition of Macleay to the feeds of pigs at the dose of 72 and 210 mg/10 kg of feeds as well as «green buckwheat» at the rate of 1.25 and 6.25 g/kg of body weight in all groups led to the increase in the weight gain of piglets on average by 10–40% and it stimulated the processes of antioxidant protection in the experimental piglets that was characterized by the inhibition of the processes of peroxidation of lipids (POL) (the decrease in the concentration of its primary and secondary TBA-active products– dien conjugates (DC) and malonic dialdehyde (MDA)) and also at first the increase and then the decrease to the normal physiological activity of antioxidant enzymes (catalase and superoxide dismutase (SOD)) and the restoration of the pool of endogenous total antioxidant activity (AOA).
The data on the impact of the drug «Neoverm» on the dogs have been presented in the article. The drug was administered into the stomach at the dose of 0.6 mg/kg of live weight for three days and the antioxidant drugs «E–Selenium» and «Quercetin» as well as green buckwheat and hepaprotector «L’esphal» as natural antioxidant preparations were used. «Neoverm» is a new antiparasitic drug that belongs to the group of medicines of broad–spectrum of action of the avermectin derivatives.The main active substance is ivermectin (10 mg), it belongsto the group of compounds which are the product of enzymic activity of the mycelium Streptomycesavermitilis. Ivermectinentersthebody of the parasite with the wasteproducts, it stimulates theproductionofneuromediator of inhibition – gamma–aminooleicacid that leadsto the disruptionofnerveimpulsetransmission, paralysisanddeathoftheparasite. The drug isused to treat varioustypesofdomesticanimalsandpoultry.On the basis of the results of the researches it has been established that the use of the drug «Neoverm» as a therapeutic agent alongwith «E–selenium», «Quercetin» and «L’esphal» and the correction of the ration with natural antioxidants has led to the gradual normalization of the processes of lipid peroxidation (LPO)in the blood of dogs, it was accompaniedby the significant (p ≤ 0.01) decrease in the formation of primary and final toxic by–products: dien conjugates (DC) and malonicdialdehyde (MDA) as well as the restoration of endogenous antioxidant resources (normalization of the activity of the enzyme catalase – the main indicator of the work of antioxidant system, the level of total antioxidant activity (AOA), the increase in the concentration of structural components of non–fermentative part of the antioxidant system (AOS) –vitamin E and Selenium).It has been pointed out that both correction schemes (the combination of «E–selenium» with «Quercetin» and green buckwheat with «L‘espal» gave good results, that is the basis for the use of the above drugs in the protective action.
In fact, Free radical oxidation is one of the required factors of homeostasis as far as the active forms of oxygen, which have unpaired electron, perform useful functions, they are necessary intermediaries of numerous processes of normal cells’ functioning such as biosynthesis of prostaglandins and leukotriene as well as other biologically active substances. Also, they take part in pathological processes such as: inflammation, fever and others. Free radical oxidation is the process of direct oxygen transferring to the substrate forming peroxide, ketones, aldehydes, etc. Some amino acids, proteins, water and carbohydrates prone to the processes of peroxidation, but crucial place is granted to lipids at the expanse of fatty acids which are included to their composition. The article highlights the information concerning the analysis of the state of antioxidant system of hens in the process of feeding them with subtoxic doses of fungicide of Derosal (BAYER, Germany) (0.1 LD50 for a fowl, 900 mg/kg of the body mass) which active ingredient is benzimidazole carbamate (carbendazim, BMC). It presents the changes of these indicators in the process of using pharmacological and natural antioxidants. The analysis has figured out that giving Derosal to the hens without corrections (II group) has been followed with the activation of the process of lipids’ peroxidation (POL) in the blood plasma, that is followed with the increase of concentration of primary and secondary lipoperoxidation products – diene conjugates (DC) and TBA-active products on the average up to 21.0–25.0 %, catalase activity – up to 38.5 % and decrease of superoxide dismutase activity (SOD) up to 21.8 % and АОА – up to 17.8 %, that shows the adverse effects of pesticides on the system of antioxidant protection of the organism. In the fowls’ groups III, IV and V the adding of antioxidant E-selenium, ascorbic acid and thermally untreated buckwheat seeds as the source of quercetins and anthocyanins has led to the induction of antioxidant resources that is shown by the decrease in comparison with the control of content of diene conjugates, malonic dialdehyde and catalase (in average up to 13.6–33.6–18.0 % accordingly) and compensatory strengthening of superoxide dismutase activity and general activity of antioxidant (АОА) on the average up to 44.9–72.1–76.5 % and 15.3–13.4–21.7 % accordingly. In comparison with group II the activity of catalase has been lower as well as the activity of superoxide dismutase has been higher in all the groups almost in 1.5–2 times (Р ≤ 0.001).
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