The data on the impact of the drug «Neoverm» on the dogs have been presented in the article. The drug was administered into the stomach at the dose of 0.6 mg/kg of live weight for three days and the antioxidant drugs «E–Selenium» and «Quercetin» as well as green buckwheat and hepaprotector «L’esphal» as natural antioxidant preparations were used. «Neoverm» is a new antiparasitic drug that belongs to the group of medicines of broad–spectrum of action of the avermectin derivatives.The main active substance is ivermectin (10 mg), it belongsto the group of compounds which are the product of enzymic activity of the mycelium Streptomycesavermitilis. Ivermectinentersthebody of the parasite with the wasteproducts, it stimulates theproductionofneuromediator of inhibition – gamma–aminooleicacid that leadsto the disruptionofnerveimpulsetransmission, paralysisanddeathoftheparasite. The drug isused to treat varioustypesofdomesticanimalsandpoultry.On the basis of the results of the researches it has been established that the use of the drug «Neoverm» as a therapeutic agent alongwith «E–selenium», «Quercetin» and «L’esphal» and the correction of the ration with natural antioxidants has led to the gradual normalization of the processes of lipid peroxidation (LPO)in the blood of dogs, it was accompaniedby the significant (p ≤ 0.01) decrease in the formation of primary and final toxic by–products: dien conjugates (DC) and malonicdialdehyde (MDA) as well as the restoration of endogenous antioxidant resources (normalization of the activity of the enzyme catalase – the main indicator of the work of antioxidant system, the level of total antioxidant activity (AOA), the increase in the concentration of structural components of non–fermentative part of the antioxidant system (AOS) –vitamin E and Selenium).It has been pointed out that both correction schemes (the combination of «E–selenium» with «Quercetin» and green buckwheat with «L‘espal» gave good results, that is the basis for the use of the above drugs in the protective action.
Ключові слова: НЕОМЕРМ, КУРИ, ПЕРЕКИСНЕ ОКИСНЕННЯ ЛІПІДІВ (ПОЛ), ДІЄНОВІ КОН'ЮГАТИ (ДК), МАЛОНОВИЙ ДІАЛЬДЕГІД (МДА), АНТИОКСИДАНТНА СИС ТЕМА (АОС), АНТИОКИСНЮВАЛЬНА АКТИВНІСТЬ (АОА), СЕЛЕН, ВІТАМІН Е, АК ТИВНІ ФОРМИ КИСНЮ (АФК) PROPHYLAXIS OF OXIDATIVE STRESS AND CORRECTION OF ANTIOXIDANT PROTECTION OF POULTRY POISONED BY NEOVERM (by 1.9, 0.23 (P≤0,05) and 2.3 times (P≤0,01), respectively) that demonstrates the formation of oxidative stress in the experimental hens.
The article presents the data on the effect of antihelmintic and imunomodulating drug «Neoverm» on the dogs’ body when the drug was administered into the stomach of the animals within three days and the results of its application in the combination with the drugs that contain antioxidant and membrane stabilizing substances. To protect the body from toxic action of «Neoverm» the drugs were used under two schemes: «E-Selenium» and «Quercetin», phospholipid hepaprotector «Lesphal» and «green buckwheat» (a feed additive – pre-ground raw buckwheat as a natural source of quercetin). The result a were compared with the control group and the group that received only «Neoverm». It has been found out that the use of «Neoverm» for the dogs both on the 7th and 14th days had a negative impact on the hematological parameters and the activity of blood enzymes that reflects the functional state of the liver. In particular, the reduction in the number of erythrocytes and the level of hemoglobin as well as the significant increase in the activity of diagnostic enzymes: alanine (ALT), asparagine (AST), gammaglutamyl (GGT) transferases and alkaline phosphatase (ALP) have been revealed. The proposed schemes to correct the toxic effect of the drug «Neoverm» in dogs led to the restoration of endogenous antitoxic resources, that is, to a gradual normalization of hematological parameters and the activity of indicatory enzymes of blood (the decrease in the activity of AST, ALT, GGT, ALP and LDH and the normalization of the number of red blood cells and hemoglobin) and that is the basis for the use of the above drugs as protectors-antioxidants when «Neoverm» is used.
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