Animal reproduction is one of the main factors limiting the efficiency of livestock production. Its optimal level is possibly achieved when certain conditions are created for animals. As reproduction is a complex reflex process depending on neuroendocrine regulatory mechanisms, the character and strength of stimuli, which, in turn, is due to a number of factors. Under normal conditions, the body of animals is affected by many different factors, which are appropriately transformed and specified by positive or negative reactions. Inhibitory factors include air pool, saturated with harmful substances and gases, ionizing radiation, poor water quality along with altered redox properties, hypokinesia combined with poor unbalanced feeding, systematic chronic stress, presence of toxic substances in feed, and the deficiency of vitamins and other bioantioxidants in feed or their excessive spending. Of the wide range of genetic and paratypic factors of negative impacts on reproductive capacity, the most common one is alimentary, which causes impaired reproductive function due to deficiencies in the rules, regulations, and feeding regime of animals. In particular, the alimentary can be associated with both general malnutrition (starvation) and overfeeding (obesity). However, the alimentary form of infertility mostly occurs due to low-quality diets when the diet lacks vital components (mainly vitamins, macro-, and micronutrients) or the quantitative ratios of the ingredients are violated. This is possible even if the total nutritional value of the diet meets the established requirements for the physiological needs of the body. Vitamins, micro-, and macronutrients are ecologically deficient factors of disturbance of animal reproductive function, the influence of which is observed on all processes of reproduction, from fertilization to the postpartum period and the preservation of young animals. The pathogenesis of their insufficiency is associated with the violation of steroido-, gameto-, and embryogenesis and the emergence of ante-, intra-, neo- and postnatal pathologies, respectively. Therefore, treatments and prevention measures should be aimed at providing animals with biologically complete balanced feeding and replenishment of the body with vitamins and minerals. However, all these issues remain incompletely studied and need further research.
Recently the assessment of QTL genes has been a relevant focus of research. Among other genes, the RYR1 is one of the most important. Research on this gene for Landrace sows of Ukrainian selection has been insufficient. This fact confirms the need for our work. A total of 63 Landrace sows from different families were evaluated by reproductive qualities for two generations. A comprehensive assessment of the sows’ reproductive ability was performed using the SIRQS-index. Determination of polymorphism in the RYR1 gene in pigs was performed by using DNA-typing of animals. Genetic potential was calculated between two generations “mother-daughter”. By assessment of polymorphism of the RYR1 gene, it was found that 6.3% of the Landrace sows were the carriers for the mutant allele of the RYR1 gene. No animals with the RYR1nn genotype were detected. Accordingly, animals with the RYR1NN genotype accounted for 93.6%. The frequency of the N allele of the RYR1 gene was 0.97, the n frequency of the RYR1 gene allele was 0.03. Sows with RYR1NN genotype had a higher level of reproductive ability compared to the RYR1Nn genotype. RYR1NN genotype also had a higher level of genetic potential. The greatest progress was established between generations of Landrace sows which were carriers for the mutant allele. The highest values of this progress were by the NBA, the lowest – by the NW. On the contrary, there was regression between populations for part of the population (Landrace sows of Ukrainian selection of RYR1Nn genotype) by the all estimated indicators of reproductive ability. Sows that were free of the mutant allele of the RYR-1 gene had high SIRQS index. The phenotypic consolidation coefficients by the NBA were lower for sows free of the mutant allele than for its carrier. The advantage of sows free of the mutant allele of the RYR-1 gene over its carrier sows was established in almost all assessed indicators of reproductive ability. No significant differences in the level of consolidation of reproductive ability between sows with different allelic variants of the RYR-1 gene were established. The higher productive level of sows with RYR1NN genotype is reflected in the indicators of economic efficiency of production. It allows higher levels of profitability to be obtained and net profit to be increased by 1093 UAH compared to sows with RYR1Nn genotype. The further monitoring of the studied gene and the gradual elimination of carriers of the mutant allele is a promising direction in breeding work.
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