Replication and bioactivation of Ti-based alloy scaffold macroscopically identical to cancellous bone from polymeric template with TiNbZr powders

Rao, Xi; Yang, Jihan; Li, Jing; Feng, Xue; Chen, Zilin; Yuan, Yidie; Yong, Binglian; Chu, Chenglin; Tan, Xiang-Yang; Song, Qi

doi:10.1016/j.jmbbm.2018.08.031

Cited by 11 publications

(6 citation statements)

References 54 publications

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“…The ideal material for implants should possess bioactivity that is similar to that in natural bone, thus encouraging osseointegration and the formation of reliable bone-implant contact. Titanium and its alloys have been widely used in dental and orthopedic implants, given their superior biocompatibility, excellent corrosion resistance, and favorable mechanical properties [ [1] , [2] , [3] ]; however, because they are considered bio-inert, they are not anticipated to augment bio-interaction with surrounding tissues [ 4 , 5 ]. To enhance surface bioactivity while retaining desirable inherent characteristics, titanium and its alloys are commonly surface-coated to shorten osseointergration periods [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound

Cai

Jiao

Quan

et al. 2021

Bioactive Materials

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Developing bioactive materials for bone implants to enhance bone healing and bone growth has for years been the focus of clinical research. Barium titanate (BT) is an electroactive material that can generate electrical signals in response to applied mechanical forces. In this study, a BT piezoelectric ceramic coating was synthesized on the surface of a TC4 titanium alloy, forming a BT/TC4 material, and low-intensity pulsed ultrasound (LIPUS) was then applied as a mechanical stimulus. The combined effects on the biological responses of MC3T3-E1 cells were investigated. Results of scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction showed that an uniform nanospheres -shaped BT coating was formed on TC4 substrate. Piezoelectric behaviors were observed using piezoelectric force microscopy with the piezoelectric coefficient d 33 of 0.42 pC/N. Electrochemical measures indicated that LIPUS-stimulated BT/TC4 materials could produce a microcurrent of approximately 10 μA/cm 2 . In vitro , the greatest osteogenesis (cell adhesion, proliferation, and osteogenic differentiation) was found in MC3T3-E1 cells when BT/TC4 was stimulated using LIPUS. Furthermore, the intracellular calcium ion concentration increased in these cells, possibly because opening of the L-type calcium ion channels was promoted and expression of the Ca V 1.2 protein was increased. Therefore, the piezoelectric BT/TC4 material with LIPUS loading synergistically promoted osteogenesis, rending it a potential treatment for early stage formation of reliable bone-implant contact.

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Section: Introductionmentioning

confidence: 99%

Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound

Cai

Jiao

Quan

et al. 2021

Bioactive Materials

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“…100–500 μm pore sizes, with ca. 100 μm wide struts) were developed by a slurry coating of polymer foams using TiNbZr powders, which were sintered and followed by hydrothermal titanate formation to mimic geometries of cancellous bone (Figure 13(A)) [157]. In addition, electrochemical routes by anodic oxidation have been used within the literature to form ‘nanoflower-like’ titanate coatings, driven by applied voltages/currents or 350 V and 70 mA cm −2 in a custom electrolyte of β -glycerophosphate, calcium acetate and NaOH.…”

Section: Medical Alkaline Titanatesmentioning

confidence: 99%

Developing alkaline titanate surfaces for medical applications

Wadge

McGuire

Thomas

et al. 2023

International Materials Reviews

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Improving the surface of medical implants by plasma spraying of a hydroxyapatite coating can be of critical importance to their longevity and the patient's convalescence. However, residual stresses, cracking, undesired crystallisation and delamination of the coating compromise the implants lifetime. A promising alternative surface application is an alkali-chemical treatment to generate bioactive surfaces, such as sodium and calcium titanate and their derivatives. Such surfaces obviate the need for high temperatures and resulting micro-crack formation and potentially improve the bioactive and bone integration properties through their nanoporous structures. Also, metallic ions such as silver, gallium and copper can be substituted into the titanate structure with the potential to reduce or eliminate the infections. This review examines the formation and mechanisms of bioactive/antibacterial alkaline titanate surfaces, their successes and limitations, and explores the future development of implant interfaces via multifunctional titanate surfaces on Ti-based alloys and on alternative substrate materials.

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“…Compressive strength of 84 MPa was achieved for a porosity of 66%. In [108], a new type of porous Ti-based alloy scaffold with a porosity of about 75% and interconnected pores in the range of 300-1000 µm was fabricated with Ti-Nb-Zr powders. This porous scaffold exhibited a compressive strength of 14.9 MPa and an elastic modulus of 0.21 GPa, resembling the mechanical properties of natural human cancellous bone obtained in this study, which could be potentially used for bone tissue engineering application.…”

Section: Polymeric Sponge Replicationmentioning

confidence: 99%

“…Table 5 demonstrates the materials applied for scaffolds together with fabrication techniques. Ti-10Nb-3Mo Powder metallurgy [99] Ti-20Nb-15Zr Sponge replication process [108] Ti-35Zr-28Nb Powder metallurgy [198,199] SLM [113] Ti-30Nb-5Ta-3Zr SLM [164]…”

Section: Titanium and Its Alloys For Manufacturing Of Scaffoldsmentioning

confidence: 99%

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

Dziaduszewska

Zieliński

2021

Materials

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One of the biggest challenges in tissue engineering is the manufacturing of porous structures that are customized in size and shape and that mimic natural bone structure. Additive manufacturing is known as a sufficient method to produce 3D porous structures used as bone substitutes in large segmental bone defects. The literature indicates that the mechanical and biological properties of scaffolds highly depend on geometrical features of structure (pore size, pore shape, porosity), surface morphology, and chemistry. The objective of this review is to present the latest advances and trends in the development of titanium scaffolds concerning the relationships between applied materials, manufacturing methods, and interior architecture determined by porosity, pore shape, and size, and the mechanical, biological, chemical, and physical properties. Such a review is assumed to show the real achievements and, on the other side, shortages in so far research.

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Replication and bioactivation of Ti-based alloy scaffold macroscopically identical to cancellous bone from polymeric template with TiNbZr powders

Cited by 11 publications

References 54 publications

Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound

Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound

Developing alkaline titanate surfaces for medical applications

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

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