2021
DOI: 10.3390/ma14040712
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Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

Abstract: One of the biggest challenges in tissue engineering is the manufacturing of porous structures that are customized in size and shape and that mimic natural bone structure. Additive manufacturing is known as a sufficient method to produce 3D porous structures used as bone substitutes in large segmental bone defects. The literature indicates that the mechanical and biological properties of scaffolds highly depend on geometrical features of structure (pore size, pore shape, porosity), surface morphology, and chemi… Show more

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Cited by 39 publications
(20 citation statements)
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References 247 publications
(325 reference statements)
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“…The first coating may be then considered in such applications in which the coating opposes high stresses and must be resistant to wear or cracking. The second coating, which includes antibacterial metal, can be recommended for particular coatings that should actively kill bacteria in their neighborhood [56], but with no excessive loads during surgery and further use of the implant.…”
Section: Discussionmentioning
confidence: 99%
“…The first coating may be then considered in such applications in which the coating opposes high stresses and must be resistant to wear or cracking. The second coating, which includes antibacterial metal, can be recommended for particular coatings that should actively kill bacteria in their neighborhood [56], but with no excessive loads during surgery and further use of the implant.…”
Section: Discussionmentioning
confidence: 99%
“…Gupta et al (2021) studied the tensile behavior of EBMed Ti64 alloy and resulted that the tensile strength is highly affected by the strain rate and temperature whereas the existence of micro-cracks reduces the tensile strength and ductility. As the mechanical properties of bone depend on age, activity and disease status, therefore proper matching of elastic modulus constitutes a major challenge for tissue engineering (Dziaduszewska and Zieli nski, 2021). The desired mechanical properties in Pure Ti can be achieved by the addition of alloying with the help of alloying elements such as Nb, Zr, Sn and Ta.…”
Section: Mechanical Propertiesmentioning
confidence: 99%
“…Several surface properties can affect these interactions, including chemical composition, surface energy, roughness, and topography [1][2]. These interactions would be successful if a balance between two dichotomous characteristics of the implant surface could be achieved: a sufficient surface roughness for a progressive cellular bio-adhesion and an adequate smoothness and wettability for easier bacteria removing [3][4]. This balance could be accomplished if the implant surface could reproduce to a certain extent the patterns/nano-geometries of the natural healthy tissue at nano-metric scale, being capable by this to enhance cell bio-adhesion [3][4].…”
Section: Introductionmentioning
confidence: 99%
“…These interactions would be successful if a balance between two dichotomous characteristics of the implant surface could be achieved: a sufficient surface roughness for a progressive cellular bio-adhesion and an adequate smoothness and wettability for easier bacteria removing [3][4]. This balance could be accomplished if the implant surface could reproduce to a certain extent the patterns/nano-geometries of the natural healthy tissue at nano-metric scale, being capable by this to enhance cell bio-adhesion [3][4]. This difficult challenge represents the reason why the functionalization of the implant surfaces is of maximum interest for the scientific domain now.…”
Section: Introductionmentioning
confidence: 99%