Repair of surgical wounds in rats using a 10% unripe Musa sapientum peel gel

Abstract

PURPOSE:To investigate the efficacy of a 10% gel of unripe banana (Musa sapientum) peel in treating surgical wounds in rats. METHODS:A longitudinal, prospective, randomized triple-blind study was conducted with 60 Wistar rats (Rattus norvegicus albinus) weighing approximately 400g. The animals were randomly divided into: control group (treated with gel containing no active ingredient) and study group (treated with 10% gel of unripe banana peel). The gel was applied every three days to a 4x4-cm surgical wound created on the back of each animal (day 0) in both groups. Tissue samples were collected for histological analysis on days 14, 21 and 28. RESULTS:On day 14, more extensive vascular proliferation (p=0.023), presence of mononuclear cells (p=0.000), fibroblast proliferation (p=0.012), re-epithelialization (p=0.000), and decreased presence of polymorphonuclear cells (p=0.010) were observed in the study group than in controls. No significant between-group difference in the presence of polymorphonuclear cells was found on day 21.Fibroblast proliferation was significantly greater (p=0.006) in the study group than in the control group on day 28. CONCLUSION:The 10% gel of unripe banana peel showed anti-inflammatory activity and stimulated wound healing in rat skin when compared with a gel containing no active ingredient.

Production, application and health effects of banana pulp and peel flour in the food industry

“…With regard to presented results, BPe extract was found to inhibit lipid oxidation better than pulp extract (Someya et al 2002). Recently, it has been shown that gallocatechin extracted from GBPe was effective in the healing of surgical wounds in rats (Von Atzingen et al 2015). Correspondingly, a unique flavonoid named leucocyanidin was found in aqueous extract of unripe plantain pulp, which is now known to be effective in the treatment of gastric diseases (Lewis et al 1999).…”

The effect of source animal age, decellularization protocol, and sterilization method on bovine acellular dermal matrix as a scaffold for wound healing and skin regeneration

“…The residual DNA content was measured by the method described in other studies 35 . Briefly, 50 mg of the dry sample were incubated with DNA extraction buffers of FavorPrep™ Tissue Genomic DNA Extraction mini kit.…”

“…The residual DNA content was measured by the method described in other studies. 35 Briefly, 50 mg of the dry sample were incubated with DNA extraction buffers of FavorPrep™ Tissue Genomic DNA Extraction mini kit. The isolation process included tissue lysis, DNA collection, washing, elution, and solvent preparation, orderly.…”

Active compounds in kepok banana peel as anti-inflammatory in acne vulgaris: Review article

“…Gallocatechin is another phenolic antioxidant identified in banana peel. It has higher amount in the peel (158 mg/100 g of dry weight) than in the pulp (29.6 mg/100 g of dry weight) according to studies on M. cavendishii Lamb [ 68 , 69 ]. Other phenolics found in banana peel include catecholamines, flavanones, flavonols, tocopherols [ 70 ].…”