Renal antioxidant enzymes: Their regulation and function

Ichikawa, Iekuni; Kiyama, Shigeru; Yoshioka, Toshimasa

doi:10.1038/ki.1994.1

Cited by 175 publications

(128 citation statements)

References 97 publications

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“…The treatment for Chronic kidney sickness can be either dialysis or renal transplantation 2 . Over the most recent decade accessible oxygen genus (ROS) assume a input in pathophysiology of extensive assortment of renal ailments by trial evidence 3 . The most imperative free radicals in numerous illness states are oxygen subsidiaries, especially superoxide (O 2 -), hydroxyl radical (OH-), hydroperoxy radical (HOO), lipid peroxide radical (ROO), Nitric Oxide (NO), peroxy nitrite (ONOO) are in charge of a significant number of organic impacts of free radical inside the human body 4 .…”

Section: Introductionmentioning

confidence: 99%

Pro oxidants and Antioxidants Levels in Chronic Renal Failure Patients Treated by Dialysis

Kundoor

Mohanty

Narsini

et al. 2017

AJPRHC

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To assess adjustments in star oxidant and cancer prevention agent state in pre and post hemodialysis patients experiencing ceaseless renal disease. The study was led on 100 perpetual renal disappointment patients going to outpatient division of nephrology dialysis unit in relationship with bureau of organic chemistry at Kamineni establishment of therapeutic Sciences, Narketpally, Nalgonda district, Telangana. Age between 30-70 years of either sex measuring their estimated oxidant levels of serum malondialdehyde, serum protein carbonyls and anti-oxidant levels of serum superoxide dismutase, serum catalase prior and then afterward the dialysis session coordinated controls. In the present study, we have observed significant increase in levels of pro-oxidants serum malondialdehyde and serum protein carbonyls fixation and there was reduction in chemical action of cell reinforcement serum superoxide dismutase and serum catalase. Our study highlights the need of screening of cancerous agents in renal Patients in regular intervals for better treatment outcomes and also to improve quality of life of the patients.

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Section: Introductionmentioning

confidence: 99%

Pro oxidants and Antioxidants Levels in Chronic Renal Failure Patients Treated by Dialysis

Kundoor

Mohanty

Narsini

et al. 2017

AJPRHC

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“…These agents include iron chelators, glutathione, alpha-tocopherol, alpha lipoic acid, D-methionine, dexamethasone, trimetazidine, ebselen, N-acetylcysteine, thymoquinone, and steroids [6] .…”

Section: Introductionmentioning

confidence: 99%

A Prospective Experimental Study on the Protective Effect of Resveratrol against Amikacin-Induced Ototoxicity in Rats

Avcı¹,

Erkan²,

Sönmez³

et al. 2016

Int Adv Otol

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OBJECTIVE:The purpose of this study was to evaluate the protective effect of resveratrol against amikacin-induced ototoxicity in rats by otoacoustic emission and histopathology of the cochlea. MATERIALS and METHODS:This study was conducted with 31 Sprague Dawley adult female rats that were 20-21 weeks old and 190-245 g in weight. Before the drug administration, distortion product otoacoustic emission (DPOAE) tests were performed in both ears of each rat. The rats were divided into four groups. Group 1 (n=7) received ethanol 1cc 4%, Group 2 (n=8) received 600 mg/kg amikacin, Group 3 (n=8) received 10 mg/kg resveratrol and 600 mg/kg amikacin, and Group 4 (n=8) received 1cc resveratrol at 10 mg/kg. The drugs were administered once a day for 21 consecutive days. Control DPOAE tests were performed at the 7 th , 14 th , and 21 st days after the administration of drugs. At the end of the study, the rats were sacrificed and their cochleae were dissected. The cochleae were evaluated for histopathologic changes. RESULTS:There was no statistically significant difference in the DPOAE measurements before the procedure between groups. The DPOAE measurements significantly decreased after the procedure in the amikacin group. There was no statistically significant difference in DPOAE measurements after the procedure in the amikacin + resveratrol, resveratrol, and ethanol groups. The histopathologic findings supported these results. CONCLUSION:We found that if resveratrol is administered with amikacin, the severity of amikacin-induced hearing loss is decreased. These findings suggest that resveratrol, a strong antioxidant, has a protective effect in amikacin ototoxicity.

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“…The decrease in antioxidant defence was more marked in the final stage of CKD as in the initial stages the transcriptional upregulation of antioxidant enzyme levels in response to increased ROS activity keep the SOD levels from falling greatly. 19 A highly significant positive correlation was found between serum superoxide dismutase levels and hemoglobin concentration. In CKD, the defective antioxidant environment exposed the RBCs to severe oxidative damage by superoxide radical, decreasing their life span.…”

Section: Discussionmentioning

confidence: 89%

Correlation of hemoglobin with creatinine clearance, antioxidant status, lipid peroxidation and ceruloplasmin in patients with chronic kidney disease

Sheeba

Kumar

2016

Int J Res Med Sci

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Renal antioxidant enzymes: Their regulation and function

Cited by 175 publications

References 97 publications

Pro oxidants and Antioxidants Levels in Chronic Renal Failure Patients Treated by Dialysis

Pro oxidants and Antioxidants Levels in Chronic Renal Failure Patients Treated by Dialysis

A Prospective Experimental Study on the Protective Effect of Resveratrol against Amikacin-Induced Ototoxicity in Rats

Correlation of hemoglobin with creatinine clearance, antioxidant status, lipid peroxidation and ceruloplasmin in patients with chronic kidney disease

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