Pro oxidants and Antioxidants Levels in Chronic Renal Failure Patients Treated by Dialysis

Abstract

To assess adjustments in star oxidant and cancer prevention agent state in pre and post hemodialysis patients experiencing ceaseless renal disease. The study was led on 100 perpetual renal disappointment patients going to outpatient division of nephrology dialysis unit in relationship with bureau of organic chemistry at Kamineni establishment of therapeutic Sciences, Narketpally, Nalgonda district, Telangana. Age between 30-70 years of either sex measuring their estimated oxidant levels of serum malondialdehyde, serum protein carbonyls and anti-oxidant levels of serum superoxide dismutase, serum catalase prior and then afterward the dialysis session coordinated controls. In the present study, we have observed significant increase in levels of pro-oxidants serum malondialdehyde and serum protein carbonyls fixation and there was reduction in chemical action of cell reinforcement serum superoxide dismutase and serum catalase. Our study highlights the need of screening of cancerous agents in renal Patients in regular intervals for better treatment outcomes and also to improve quality of life of the patients.

Estimation of Oxidant and Antioxidant Levels in Hemodialysis Treated end Stage Renal Disease Patients and Comparison with Normal Population

“…Moreover the selective permeability of the dialyzer membrane to antioxidants also significantly contributes to the decreased levels of antioxidants in these patients as the antioxidants are decreased after every cycle of dialysis. Our results are similar to the published work of Rysz et al 16 and Kundoor et a.l 20 Marjani et al 21 antioxidant levels in hemodialysis patients. These findings of our study and international studies show that hemodialysis patients are subjected to a constant reduction in antioxidant levels due to repeated infections, dietary restrictions, removal of antioxidants during dialysis procedure, impermeability of the dialyzer membrane to antioxidants and enhanced inflammatory cascade.…”

“…Serum malondialdehyde was also significantly increased in hemodialysis group (31.01 U/ml) as compared to control group (10.87U/ml). Kundoor et al 20 and Barati et al 22 also described a significant increase in serum MDA in hemodialyzed patients as compared to controls. The possible mechanism which leads to an increase in MDA levels is that ROS activate phospholipase A2 causing peroxidation of many mediators by arachidonic acid which is finally metabolized to MDA.…”

Correlation between Serum Malondialdehyde levels and prevalence of cardiovascular disease in Haemodialysis treated patients

“…Serum MDA was also significantly increased in the patient group. Kundoor et al 25 and Marjani et al 26 also described a significant increase in serum MDA in haemodialysed patients compared to the controls. The possible mechanism which leads to increase in MDA levels is that ROS activate phospholipase A2, causing peroxidation of many mediators by arachidonic acid which are finally metabolised to MDA.…”