Relationships between lipid profiles and metabolic syndrome, insulin resistance and serum high molecular adiponectin in Japanese community-dwelling adults

Abstract

BackgroundThere are few studies to demonstrate the associations between newly addressed lipid profiles and metabolic syndrome (MetS)-associated variables.MethodsStudy participants without medications for hypertension, diabetes, or dyslipidemia {614 men aged 58 ± 14 (mean ± standard deviation; range, 20-89) years and 779 women aged 60 ± 12 (range, 21-88) years} were randomly recruited from a single community at the time of their annual health examination. The association between lipid profiles (total cholesterol (T-C), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, T-C/HDL-C, TG/HDL-C, LDL-C/HDL-C ratio and MetS, Insulin resistance by homeostasis model assessment of insulin resistance (HOMA-IR), and serum HMW adiponectin were analyzed.ResultsIn multiple linear regression analysis, TG/HDL-C and T-C/HDL-C ratios as well as TG showed significantly strong associations with all three MetS-associated variables in both men and women. In men, the ROC curve analyses showed that the best marker for these variables was TG/HDL-C ratio, with the AUC for presence of MetS (AUC, 0.82; 95% CI, 0.77-0.87), HOMA-IR (AUC, 0.75; 95% CI, 0.70-0.80), and serum HMW adiponectin (AUC, 0.67; 95% CI, 0.63-0.71), respectively. The T-C/HDL-C ratio, TG, HDL-C, LDL-C/HDL-C ratio, and non-HDL-C also discriminated these markers; however all their AUC estimates were lower than TG/HDL-C ratio. These results were similar in women.ConclusionIn Japanese community-dwelling adults, lipid ratios of TG/HDL-C, T-C/HDL-C, LDL-C/HDL-C as well as TG and HDL-C were consistently associated with MetS, insulin resistance and serum HMW adiponectin. Lipid ratios may be used as reliable markers.

Gender differences in serum high-molecular-weight adiponectin levels in metabolic syndrome

“…At first, HOMA-IR as a marker for IR was superior to HMW adiponectin to predict the presence of MS in both genders (estimated by AUROC). This result was in line with a Japanese study where HOMA-IR predicted the presence of MS better than HMW adiponectin (AUC 0.75 vs 0.67 respectively) in subjects without medications for hypertension, diabetes, or dyslipidemia (15).…”

“…Therefore, these results demonstrate a tighter relationship between HMW adiponectin and MS in women. Associations between HMW adiponectin levels and the presence of MS have been studied previously in Japanese (9,15), Caucasian American (19), Japanese American (25), Thai (17), Korean (18), and Chinese subjects (16). No similar European population-based surveys assessing the association between HMW adiponectin and MS have been performed, to the best of our knowledge.…”

“…More recent studies about associations between HMW adiponectin and MS come mainly from Asia (15,16,17,18) and the United States (19). The SWAN study from the United States showed significant racial-ethnic differences in circulating adipokine levels.…”

Lipid accumulation product is a powerful index for recognizing insulin resistance in non-diabetic individuals

“…7 Some antropometric measurements, such as body mass index (BMI), waist circumference (WC), are usually used for identifying IR. 8,9 However, such indexes are not comprehensive in reflecting an individual's obesity and metabolic abnormalities. BMI is easy to measure and is typically used to predict the risk of metabolic abnormalities.…”

Oxidized LDL as A Biomarker in Metabolic Syndrome

“…Total fasting cholesterol and fasting lowdensity lipoproteins showed increasing trend with all groups but did not reaches up to the statistically significance level. In our study we also determined that low levels of high-density lipoproteins cholesterol (HDL-C) and elevated levels of triglycerides (TG) in all the groups as compared to the normal group were associated with the risk of metabolic syndrome and type-2 diabetes [12][13][14].…”