Gender differences in serum high-molecular-weight adiponectin levels in metabolic syndrome

Eglit, Triin; Lember, Margus; Ringmets, Inge; Rajasalu, Tarvo

doi:10.1530/eje-12-0688

Cited by 38 publications

(31 citation statements)

References 30 publications

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“…For example, elevated adiponectin levels were found to be associated with risk of fracture in older adult males but not in females (33). Adiponectin levels were also shown to be associated with various metabolic risk factors in females but not in males (34). Furthermore, gender differences were found in the association between adiponectin and longevity (20), insulin resistance (35) and BMI (36).…”

Section: Discussionmentioning

confidence: 99%

Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration

Khabour

Abu-Rumeh

Al-Jarrah

et al. 2014

Experimental and Therapeutic Medicine

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Lumbar disc degeneration (LDD) is a widespread public health problem that may lead to disability and loss of productivity. Adiponectin is an adipokine secreted by adipose tissue and has been shown to be involved in cartilage homeostasis. In the present study, the association between the rs266729 (−11377C/G) and rs2241766 (45T/G) single nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and LDD was investigated. In addition, the correlation between the plasma adiponectin level and LDD was examined. A total of 289 subjects, 168 patients with LDD and 122 healthy individuals, were recruited in the study. All subjects were genotyped for rs266729 and rs2241766 SNPs using polymerase chain reaction-restriction fragment length polymorphism. Circulating levels of adiponectin protein were measured using the ELISA technique. A strong association was found between adiponectin level and LDD (P<0.01), where high levels of adiponectin were found in patients compared with healthy controls. The increase in adiponectin level was not affected by gender. However, no significant differences were found in the genotype distribution or allelic frequency of the two examined polymorphisms between patients with LDD and healthy controls (P>0.05). In conclusion, adiponectin appears to be elevated in patients with LDD. The rs266729 and rs2241766 SNPs in the ADIPOQ gene are not associated with LDD.

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Section: Discussionmentioning

confidence: 99%

Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration

Khabour

Abu-Rumeh

Al-Jarrah

et al. 2014

Experimental and Therapeutic Medicine

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“…The associations between adiponectin level and the components of the insulin-resistance syndrome (including BMI and glucose level) have been observed in both general population and patients with chronic kidney disease (Guebre-Egziabher et al, 2005;Tsao et al, 2008;Ramos et al, 2009;Lee et al, 2011;An et al, 2011;Eglit et al, 2012). In subjects with metabolic syndrome, patients with type 2 diabetes or coronary artery disease the serum total adiponectin level is reduced (Kacso et al, 2010;Hara et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Guebre-Egziabher et al showed that although serum adiponectin level increased when renal function was deteriorated in patients with CKD, at the same time its level was still more significantly influenced by BMI (Guebre-Egziabher et al, 2005). A number of studies (Ramos et al, 2009;Hara et al, 2011;Eglit et al, 2012) showed significant positive association of adiponectin with female gender in the population of patients with normal kidney function and with CKD, both on conservative treatment or those undergoing hemodialysis. In healthy subjects high adiponectin level appears to be protective against cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Adipokines and parameters of peritoneal membrane transport in newly started peritoneal dialysis patients.

et al. 2013

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Aim: Adiponectin and leptin are two adipokines playing important roles in the regulation of body weight, appetite, carbohydrate and lipid metabolism. In patients with chronic kidney disease (CKD) adipokines accumulate in serum due to reduced renal clearance. Since adipokines have pleiotropic actions, the adipokine balance may have an impact on peritoneal membrane transport. The aim of this study was to assess whether serum adiponectin and leptin levels were related to peritoneal transport and residual renal function (RRF) in newly started peritoneal dialysis patients. Methods: 25 clinically stable patients, 4 to 6 weeks after the onset of PD, were included in the study. For each patient clinical and laboratory data were reviewed and standard PET test was performed. Serum adiponectin and leptin concentrations were determined and leptin/adiponectin (L/A) ratio was calculated. Results: Serum adiponectin correlated negatively with weight, BMI and glucose concentration. Serum leptin and L/A ratio correlated positively with BMI. Serum adiponectin correlated positively with dialysate to plasma (D/P) creatinine ratio and ultrafiltration in PET test. Serum leptin level and L/A ratio correlated strongly negatively with peritoneal creatinine clearance. Conclusions: Serum adiponectin concentration is positively associated with baseline solute transport. Leptin concentration and L/A ratio are negatively associated with dialysis adequacy in newly started PD patients.

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“…Multiple studies have indicated that the high-molecular-weight (HMW) form of adiponectin is its most active form [3], [5], [6]. Serum HMW adiponectin values are inversely correlated with the presence of metabolic syndrome in both genders [6], [7]. Analysis of the relationship between HMW adiponectin and components of metabolic syndrome have shown that HMW adiponectin is inversely associated with triglycerides, obesity and fasting glucose, and positively associated with HDL cholesterol [9]–[12].…”

Section: Introductionmentioning

confidence: 99%

“…Analysis of the relationship between HMW adiponectin and components of metabolic syndrome have shown that HMW adiponectin is inversely associated with triglycerides, obesity and fasting glucose, and positively associated with HDL cholesterol [9]–[12]. There is clear gender difference in HMW adiponectin levels: women have significantly higher HMW adiponectin levels compared to men [7], [8]. The relationship between HMW adiponectin and blood pressure has varied between different studies and also by gender [9]–[12].…”

Section: Introductionmentioning

confidence: 99%

Obesity, High-Molecular-Weight (HMW) Adiponectin, and Metabolic Risk Factors: Prevalence and Gender-Specific Associations in Estonia

2013

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BackgroundThe metabolic consequences of obesity are associated with an imbalance of adipocytokines, e.g. adiponectin. However, some obese subjects remain metabolically healthy and have adiponectin levels similar to normal body weight subjects. Current estimates of the prevalence of obesity in Estonia have relied only on self-report data.ObjectivesTo estimate the prevalence of obesity in Estonia, to test for associations between HMW adiponectin and metabolic risk factors and to test if HMW adiponectin levels differentiate metabolically healthy and metabolically unhealthy subjects.MethodsWe conducted a population-based cross-sectional multicentre study to gather history, examination and blood test results for 495 subjects aged 20–74. Metabolically healthy subjects were free from hypertension, dyslipidaemia, impaired glucose regulation and insulin resistance. Metabolically unhealthy subjects had at least one of these four metabolic abnormalities.ResultsThe prevalence of obesity was 29% in men and 34% in women. HMW adiponectin was positively correlated with HDL cholesterol and negatively correlated with triglycerides, obesity, insulin resistance and blood glucose. This effect was driven by metabolically unhealthy subjects in men, but by both metabolically healthy and metabolically unhealthy subjects in women. Metabolically healthy women had higher HMW adiponectin levels than metabolically unhealthy women. 12% of all obese subjects were metabolically healthy, and their HMW adiponectin levels were similar to normal weight subjects.ConclusionsObesity is more prevalent in Estonian adults than previously thought. HMW adiponectin levels were associated with various metabolic risk factors in metabolically healthy women but not in metabolically healthy men. For both genders, HMW adiponectin differentiates metabolically healthy obese subjects from metabolically unhealthy obese subjects.

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Gender differences in serum high-molecular-weight adiponectin levels in metabolic syndrome

Cited by 38 publications

References 30 publications

Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration

Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration

Adipokines and parameters of peritoneal membrane transport in newly started peritoneal dialysis patients.

Obesity, High-Molecular-Weight (HMW) Adiponectin, and Metabolic Risk Factors: Prevalence and Gender-Specific Associations in Estonia

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