Lipid accumulation product is a powerful index for recognizing insulin resistance in non-diabetic individuals

Abstract

BACKGROUND/OBJECTIVES: Lipid accumulation product (LAP) is an index, which combines waist circumference (WC) and triglyceride (TG) reflecting lipid accumulation. The aims of the study were to explore the relationship between LAP and insulin resistance (IR) and to assess whether LAP was superior to WC and body mass index (BMI) in identifying IR. SUBJECTS/METHODS: The study was cross-sectional and included 2524 non-diabetic subjects from China. The blood pressure (BP), anthropometric measurements, glucose levels, insulin levels and a fasting lipid profile were measured. BMI, the homeostasis model assessment of IR (HOMA-IR) and LAP were calculated. RESULTS: In both sexes, BP, BMI, total cholesterol (TC), non high-density lipoprotein cholesterol (non-HDL-C), HOMA-IR, fasting and postprandial glucose levels increased across LAP quartiles (Po0.001), while HDL cholesterol (HDL-C) levels decreased across LAP quartiles (Po0.001). Pearson's correlation analysis demonstrated that HOMA-IR was correlated with LAP, BMI, WC, TG, HDL-C and non-HDL-C in both sexes (Po0.001). Multivariate analysis demonstrated that LAP had a greater impact on HOMA-IR than BMI and WC. CONCLUSIONS: LAP is closely associated with HOMA-IR and is a powerful index that outperforms BMI and WC in identifying IR in non-diabetic individuals.

Differences between Adiposity Indicators for Predicting All-Cause Mortality in a Representative Sample of United States Non-Elderly Adults

“…This unexpected finding tends to support the recent concept that some persons with fatty livers may indeed be ''good fat storers'' [59] who can sequester excessive lipid fuel as relatively benign triglycerides. Consistent with LAP's relation to type 2 diabetes and similar clinical states [11][12][13][14][15][16], it has been proposed that triglyceride storage in liver tissue might be a marker of hepatic insulin resistance and diabetes risk, but these adverse effects of neutral triglyceride storage could be balanced by the protection it provides against lipotoxic damage to hepatocytes caused by some non-triglyceride fatty acids and their derivatives [59,60]. In other non-adipose (ectopic) tissues there could be distinct roles for lipid storage.…”

“…The LAP indicator extends this concept in the form of a continuous variable. Increased values of LAP have been associated with prevalent type 2 diabetes [11][12][13], incident type 2 diabetes [12,14], hepatic steatosis [15], and insulin resistance [16]. For this calculation we used the formulas:…”

Producto de acumulación lipídica está asociado con glucemia en estudiantes universitarias

“…Combining waist circumference with fasting triglycerides reflect, respectively, anatomic and physiological alterations associated to lipid accumulation. Thus, LAP might be used as a powerful index to predict insulin resistance in populations (6).…”

“…Mean age was 22.2 (3.6) years of age. The size of the sample calculated was of 80 students considering data from Xia et al (6), alpha = 0.05, bilateral and beta = 0.10.…”

The Lipid Accumulation Product for the Early Prediction of Gestational Insulin Resistance and Glucose Dysregulation

“…14 An increased LAP value is associated with a variety of prevalent cardiovascular risk factors 14 and metabolic conditions such as prevalent diabetes, 15 incident diabetes, 16 the homeostasis model assessment of insulin resistance (HOMA-IR), an index used for the prediction of insulin resistance, [17][18][19] and hepatic steatosis. 20 Considering that the LAP has been a successful risk marker in young adult populations, it could be a reliable marker of metabolic perturbations among pregnant women.…”