Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin

Mousa, Aya; Abell, Sally K.; Shorakae, Soulmaz; Harrison, Cheryce L.; Naderpoor, Negar; Hiam, Danielle; Moreno-Asso, Alba; Stepto, Nigel K.; Teede, Helena; Courten, Barbora de

doi:10.1002/mnfr.201700488

Cited by 32 publications

(25 citation statements)

References 76 publications

(121 reference statements)

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“…Lastly, women with hypovitaminosis D (when vitamin D was studied as a categorical variable) were more likely to have a pre‐eclampsia, as has been noted by others . Pre‐eclampsia affects 5%–6% of pregnancies and is one of the most common causes of perinatal adverse events and maternal, fetal, and neonatal mortality . The present sample had a high prevalence of this adverse event because the study was carried out at tertiary hospitals, where patients with a more severe diseases are referred.…”

Section: Discussionsupporting

confidence: 55%

“…of pregnancies and is one of the most common causes of perinatal adverse events and maternal, fetal, and neonatal mortality. 24 The present sample had a high prevalence of this adverse event because…”

mentioning

confidence: 62%

“…The association between a low vitamin D level and eclampsia/pre‐eclampsia could be attributable to the fact that vitamin D regulates the expression of vascular endothelial growth factor and pro‐inflammatory cytokines; if the vitamin D level is low, the concentration of vascular endothelial growth factor will also be low and the levels of pro‐inflammatory cytokines will be high . Levels of adiponectin have been identified as positively associated with higher levels of vitamin D in pregnancy, although the mechanism remains unclear …”

Section: Discussionmentioning

confidence: 99%

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The prevalence and clinical associations of hypovitaminosis D in pregnant women from Brazil

Chrisostomo

Skare²,

Kulak

et al. 2018

Intl J Gynecology & Obste

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Section: Discussionsupporting

confidence: 55%

mentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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The prevalence and clinical associations of hypovitaminosis D in pregnant women from Brazil

Chrisostomo

Skare²,

Kulak

et al. 2018

Intl J Gynecology & Obste

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“…Vitamin D could increase serum omentin in participant with lower serum 25(OH)D levels. Cross‐ sectional studies indicated that women with normal vitamin D levels had significantly higher omentin levels (Dikker et al, ), while another study did not show association between vitamin D and omentin in gestational diabetes (Mousa et al, ). An intervention showed that fortified yogurt with vitamin D for 12 weeks increased the serum levels of omentin, improved glucose markers (except HbA 1 c) and inflammation in postmenopausal women with type 2 diabetes in comparison with plain yogurt (Jafari et al, ).…”

Section: Discussionmentioning

confidence: 99%

The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

Fazelian

Paknahad

Khajehali³

et al. 2018

J Food Biochem

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Type 2 diabetes (T2DM) is a global problem that increases the risk of inflammation and hormonal dysfunction. The purpose of this study was to determine the effect of vitamin D on inflammatory biomarkers, omentin, and vaspin in diabetic women with anxiety. In this study, 51 women with T2DM were allocated to receive one oral pearl of 50,000 IU vitamin D3 (26) or a placebo (25) fortnightly for 16 weeks. Anthropometric indices, dietary intake, high sensitivity C‐reactive protein (hs‐CRP), Interleukin 10 (IL‐10), vaspin, and omentin were measured at the baseline and after 16‐weeks supplementation. Serum hs‐ CRP was reduced (p = 0.01) and IL‐10 concentrations was increased (p = 0.04) in intervention group. Vitamin D marginally increased serum levels of omentin (p = 0.06), however, vaspin did not change post‐intervention. According to subgroup analysis, omentin levels increased significantly in participants with lower baseline serum vitamin D (p = 0.008). Vitamin D can improve anti‐inflammatory biomarkers in diabetic patients. Practical applications Diabetes is prevalent in the world. Inflammation in diabetic patients causes other chronic diseases such as cardio vascular disease. Adipose tissue contributes to the regulation of metabolism and insulin sensitivity. Two hormones secreted from adipose tissue that play an important role in insulin function and anti‐inflammatory activity. Vitamin D, can improve insulin sensitivity and inflammation via effects on the adipocytokines secretion. For the first time, a trial study conducted to determine the effect of vitamin D on inflammation and the serum levels of omentin and vaspin.

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“…Mousa et al [58] in a cross-sectional study discovered inverse correlations between 25(OH)D serum levels and total serum cholesterol and TG levels at 12-15 weeks of pregnancy. However, Al-Ajlan et al [36] found that 25(OH)D serum levels in the first trimester of gestation were positively correlated with lipid concentrations, which was supposed to be due to the higher biosynthesis of lipid in reaction to increased metabolic requirements in early pregnancy [59].…”

Section: Doi: 101159/000491643mentioning

confidence: 99%

Maternal and Neonatal Metabolic Outcomes of Vitamin D Supplementation in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

et al. 2018

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Introduction: Many scientists have revealed the association between vitamin D deficiency and gestational diabetes mellitus (GDM). The purpose of this review was to evaluate the impact of vitamin D supplementation on maternal and neonatal health measures in GDM. Methods: A comprehensive systematic literature search in the electronic databases including Cochrane Central Register of Controlled Trials, MEDLINE (PubMed), Scopus, Web of Sciences, EMBASE, Google Scholar, Clininaltrial.gov, and ProQuest as well as SID, Magiran, Irandoc, and Iranmedex for Persian literature review carried out up to January 2018. All RCTs and quasi-experimental studies that compared vitamin D supplementation with placebo or without supplementation on GDM women were included in this review. Results: Five randomized controlled trials involving 310 women were included in the meta-analysis. There were significant differences in fasting Plasma Glucose (FPG; mean difference [MD] –12.54, 95% CI –15.03 to –10.05; 3 trials, 223 participants); total cholesterol (TC; MD –24.77, 95% CI –32.57 to –16.98; 3 trials, 223 participants); low-density lipoprotein (LDL) cholesterol (MD –18.92, 95% CI –24.97 to –12.88; 3 trials, 223 participants); high-density lipoprotein (HDL) cholesterol (MD, 3.87, 95% CI 1.20–6.55; 3 trials, 223 participants); high sensitivity C-reactive protein (hs-CRP; MD –1.35, 95% CI –2.41 to –0.28; 2 trials, 126 participants); and Newborns’ hyperbilirubinemia (OR 0.33, 95% CI 0.13–0.80; 2 trials, 129 participants). Conclusions: Supplementation of GDM women with vitamin D may lead to an improvement in FPG, TC, LDL, HDL, hs-CRP serum levels as well as in newborns’ hyperbilirubinemia.

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Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin

Abstract: Our findings suggest that lower maternal 25(OH)D concentrations in overweight/obese pregnant women at high-risk of GDM are associated with increased cardiometabolic risks during pregnancy and adverse pregnancy outcomes, and that these associations may be mediated by HMW-adiponectin.

Cited by 32 publications

References 76 publications

The prevalence and clinical associations of hypovitaminosis D in pregnant women from Brazil

The prevalence and clinical associations of hypovitaminosis D in pregnant women from Brazil

The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

Maternal and Neonatal Metabolic Outcomes of Vitamin D Supplementation in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

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