The prevalence and clinical associations of hypovitaminosis D in pregnant women from Brazil

Chrisostomo, Kadija Rahal; Skare, Thelma L.; Kulak, Jaime; Urbanetz, Almir Antônio; Chrisostomo, Eduardo Rahal; Nisihara, Renato

doi:10.1002/ijgo.12575

Cited by 8 publications

(10 citation statements)

References 26 publications

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“…Second, the DHBC is a prospective cohort with consecutive ongoing enrollment. Third, the size of the population is similar to -or larger thansimilar studies with a population of pregnant WLWH [29][30][31].…”

Section: Discussionmentioning

confidence: 90%

Prevalence and association with birth outcomes of low vitamin D levels among pregnant women living with HIV

Bergløv

Moseholm

Katzenstein

et al. 2021

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Objectives: To evaluate the prevalence of low vitamin D levels among well treated pregnant women living with HIV (WLWH) on combination antiretroviral therapy in Denmark, to identify risk factors of low vitamin D levels, and to assess the association between vitamin D status and birth outcomes.Design: Nationwide cohort study.Methods: All WLWH in Denmark giving birth from 2000 to 2018 with a vitamin D measurement during pregnancy were identified. Risk factors for low vitamin D (deficiency or insufficiency) were assessed using log-binomial regression models, both univariate and adjusted for maternal and HIV factors. The association between vitamin D status and birth outcomes was assessed using linear regression models for continuous outcomes and log-binomial models for binary outcomes.Results: Among 208 WLWH, the prevalence of vitamin D deficiency was 13%, insufficiency 34%, and sufficiency 53%. Being of African origin (RR 2.68, P ¼ 0.01), Asian origin (RR 3.38, P ¼ < 0.01), or having HIV RNA levels more than 50 copies/ml (RR 1.43, P ¼ 0.04) was associated with an increased risk of low vitamin D level. WLWH with vitamin D deficiency had an increased risk of preterm birth (RR 2.66, P ¼ 0.03) and giving birth to small for gestational age (SGA) children (RR 6.83, P ¼ 0.02) compared with WLWH with sufficient vitamin D level. Conclusion:Low vitamin D level was prevalent among well treated pregnant WLWH in Denmark, especially among women of African or Asian origin, and women with detectable viral loads. Vitamin D deficiency was associated with an increased risk of preterm birth and SGA.

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Section: Discussionmentioning

confidence: 90%

Prevalence and association with birth outcomes of low vitamin D levels among pregnant women living with HIV

Bergløv

Moseholm

Katzenstein

et al. 2021

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“…The factors associated with the risk of vitamin D deficiency in pregnant women were being married, the use of vehicles as a means of transportation, blood collection in winter, only face and hands being exposed to the sun, preeclampsia, first pregnancy, adolescence, and low income [ 33 , 34 ]. However, a study with 226 women found no association between vitamin D deficiency and obstetric, biological, and socioeconomic variables [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Vitamin D and Calcium Deficiency and Insufficiency in Women of Childbearing Age and Associated Risk Factors: A Systematic Review and Meta-Analysis

et al. 2022

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Vitamin D deficiency and insufficiency as well as low serum calcium levels can trigger negative health outcomes in women of childbearing age. Therefore, we aimed to estimate the prevalence of serum vitamin D and calcium deficiencies and insufficiencies and associated risk factors in Brazilian women of childbearing age and to assess whether there are differences in prevalence according to regions of the country and the presence or absence of pregnancy. The systematic literature review was performed using the following databases: PubMed, LILACS, Embase, Scopus, and Web of Science. Cross-sectional, cohort, and intervention studies were included. Among pregnant women, the prevalence of vitamin D deficiency ranged from 0% to 27% and of vitamin D insufficiency from 33.9% to 70.4%. Among non-pregnant women, the prevalence of vitamin D deficiency ranged from 0% to 41.7% and of vitamin D insufficiency from 38.5% to 69.3%. We found a high prevalence of vitamin D deficiency and insufficiency in women of childbearing age, with insufficiency affecting more than half of these women. The highest prevalence of vitamin D deficiency and insufficiency was observed in the South region. It was not possible to assess the prevalence and factors associated with calcium deficiency.

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“…Vitamin D sufficiency (> 30 ng/mL) was found in 20.8% of mothers and 42.3% of newborns. Some studies in Brazil describe the 25(OH)D concentrations during pregnancy [ 10 , 11 , 14 ]. The prevalence of insufficiency/deficiency evidenced by them (range: 44.1% to 58.9%) was lower than this study, taking to account term birth (63.4%) and preterm birth (83.9%).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies evaluated 25(OH)D concentrations in Brazilian pregnant women [ 10 , 11 , 14 ]. However, no studies have been published on women who have prematurely given birth with a gestational age of fewer than 32 weeks.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D plasma concentrations in pregnant women and their preterm newborns

Kassai

Cafeo

Affonso-Kaufman

et al. 2018

BMC Pregnancy Childbirth

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BackgroundVitamin D deficiency is a global public health issue. More than half of pregnant women are affected by vitamin D insufficiency/deficiency. Studies suggest an association between low vitamin D concentrations during pregnancy with intrauterine growth restriction and prematurity. This study aimed to describe the concentrations of 25(OH)D (25-hydroxyvitamin D) of mothers who delivered preterm newborns compared to women with full-term pregnancy deliveries, as well as to relate 25(OH)D blood concentrations of mothers with those of their newborns.MethodThis cross-sectional study was conducted with 66 mothers who had given birth to preterm babies and their preterm newborns (PTNB, < 32 weeks), and 92 women who had given birth at the full-term of their pregnancy and their newborns (FTNB). Data were collected on the characteristics of mothers (gestational age, diseases, and habits) and newborns (anthropometry and adequacy for gestational age). Ten milliliters of blood were drawn from the mothers and the umbilical cord of newborns at birth to identify the 25(OH)D, parathyroid hormone, calcium, phosphorus, and alkaline phosphatase concentrations.ResultsMothers in the PTNB group had significantly lower mean 25(OH)D blood levels (21.7 ± 10.8 ng/mL vs. 26.2 ± 9.8 ng/mL; p = 0.011) and were three times more likely to have insufficiency when compared to mothers in the FTNB group (OR = 2.993; 95%CI 1.02–8.74). Newborns in the PTNB group also had lower 25(OH)D concentrations compared to FTNB group (25.9 ± 13.9 ng/dL vs. 31.9 ± 12.3 ng/dL; p = 0.009). There was a directly proportional correlation between mother and newborn umbilical cord 25(OH)D concentrations in PTNB (r = 0.596; p < 0.001) and FTNB (r = 0.765; p < 0.001).ConclusionMothers who delivered preterm babies and their preterm newborns had lower 25(OH)D concentrations compared to women who had given birth at the full-term of their pregnancy. In both groups, 25(OH)D concentrations of the mothers correlated directly with those of the newborns, and this correlation was higher in the full-term birth group. Nevertheless, the recommended universal vitamin D supplementation in pregnant women to curb the risk of preterm birth is still incipient. More studies are required to clarify the particularities of vitamin D metabolism further and define the adequate 25(OH)D concentrations throughout pregnancy.

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The prevalence and clinical associations of hypovitaminosis D in pregnant women from Brazil

Abstract: The rate of hypovitaminosis D in pregnant women from southern Brazil was high. Hypovitaminosis D was more common in winter and was associated with pre-eclampsia.

Cited by 8 publications

References 26 publications

Prevalence and association with birth outcomes of low vitamin D levels among pregnant women living with HIV

Prevalence and association with birth outcomes of low vitamin D levels among pregnant women living with HIV

Prevalence of Vitamin D and Calcium Deficiency and Insufficiency in Women of Childbearing Age and Associated Risk Factors: A Systematic Review and Meta-Analysis

Vitamin D plasma concentrations in pregnant women and their preterm newborns

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