Maternal and Neonatal Metabolic Outcomes of Vitamin D Supplementation in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Jahanjoo, Fatemeh; Farshbaf‐Khalili, Azizeh; Shakouri, Seyed Kazem; Dolatkhah, Neda

doi:10.1159/000491643

Cited by 23 publications

(11 citation statements)

References 66 publications

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“…In other words, the vitamin D levels of newborns with jaundice are low. These findings also suggest that mothers should take vitamin D to reduce the level of bilirubin in newborns [ 25 ]. Therefore, timely and effective vitamin D supplementation for pregnant mothers and newborns can reduce the risk of neonatal hyperbilirubinemia.…”

Section: Discussionmentioning

confidence: 99%

Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis

et al. 2021

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Objective Hyperbilirubinemia is a common disease in the neonatal period, and hyperbilirubinemia may cause brain damage. Therefore, prevention and diagnosis and management of hyperbilirubinemia is very important, and vitamin D may affect bilirubin levels. To evaluate the relationship between neonatal hyperbilirubinemia and vitamin D levels. Method The China National Knowledge Infrastructure, VIP, Wanfang, Chinese Biology Medicine Disc, PubMed, Web of Science, Cochrane Library, and Embase databases as well as clinical trial registries in China and the United States were searched for relevant studies from inception to September 2020 without restrictions on language, population, or year. The studies was screened by two reviewers independently, the data were extracted, and the risk of bias of the included studies was evaluated using the NOS. A meta-analysis was conducted on the included studies using Stata11 software. Results Six case-control studies were included, and the methodological quality of the studies was high (grade A). The studies included 690 newborns; more than 409 were diagnosed with hyperbilirubinemia. The means and standard deviations were calculated. Meta-analysis results showed that neonatal vitamin D levels were 7.1 ng/ml lower among infants with hyperbilirubinemia than among healthy newborn levels (z = 6.95, 95% CI 9.10 ~ 5.09, P < 0.05). Subgroup analysis was conducted based on whether the bilirubin levels were concentrated in the 15 to 20 mg/dl range. Vitamin D level of infants with hyperbilirubinemia (the bilirubin levels were concentrated in the 15 to 20 mg/dl range) was 9.52 ng/ml (Z = 15.55, 95% CI-10.72~-8.32, P<0.05) lower than that of healthy infants. The bilirubin levels in four cases were not concentrated in the 15–20 mg/dl range. The results showed that the vitamin D level of hyperbilirubinemia (The bilirubin levels were not concentrated in the 15–20 mg/dl range) neonates were 5.35 ng/ml lower than that of healthy neonates (Z = 6.43, 95% CI-6.98~-3.72, P<0.05). Conclusion Vitamin D levels were observed to be lower in neonates with hyperbilirubinemia as compared to term neonates without hyperbilirubinemia in this study. This can possibly suggest that neonates with lower vitamin D levels are at higher risk for developing hyperbilirubinemia.

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Section: Discussionmentioning

confidence: 99%

Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis

et al. 2021

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“…In our investigation there is measurably noteworthy positive maternal antenatal history of sporadic and no admission of calcium and nutrient D among patients than controls which like [8], [9], [4] and [10] examines, yet [12] study discovered factually non-huge distinction between the two contemplated bunches as respect of maternal antenatal history of admission calcium and nutrient D.…”

Section: Discussionmentioning

confidence: 58%

STUDY of 1, 25 Dihydroxy Vitamin D Level in Term Neonates with Indirect Hyperbilirubinemia

Negm

Abed

Ahmad

et al. 2020

Benha Journal of Applied Sciences

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Jaundice is the most widely recognized clinical sign in neonatal medication. In most of cases, jaundice is gentle and transient, coming about because of a youthfulness of the liver's excretory pathway for bilirubin. Thinking about the numerous functions of Vitamin D, lower levels of Vitamin D in these cases might be related with neonatal jaundice. The current examination was embraced to explore the connection between serum nutrient D levels and hyperbilirubinemia in full term youngsters. This case-control study was directed on90 youngsters, enrolled from

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“…Moreover, Zhang found similar conclusions in a meta-analysis of 20 studies conducted in Europe, Australia, North America, and Asia with different study design including cross-sectional, casecontrol, nested case-control, and cohort studies including 9209 participants [1]. Vitamin D supplementation for patients with GDM seems to ameliorate different metabolic markers including blood glucose levels, insulin resistance, and in ammatory biomarkers [14] [7]. Supplementation with 50,000…”

Section: Discussionmentioning

confidence: 63%

The vitamin D status is negatively correlated to glucose metabolism in Chinese patients with gestational diabetes

Zhang

Lai

et al. 2021

Preprint

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Background: Vitamin D deficiency plays a role in the development of patients with gestational diabetes (GDM). However, the effects and mechanism of vitamin D on fasting blood glucose are conflicting. This research aimed to explore the status of vitamin D in patients with GDM, its effect on fasting blood glucose and HbA1c, and to clarify the possible mechanism of vitamin D on glucose metabolism of patients with GDM. Methods: From January 1, 2017, to March 31, 2018, we included all the hospitalized patients with GDM. The main indices were fasting blood glucose (FBG) and 25-hydroxy vitamin D [25(OH) D], glycosylated hemoglobin (HbA1c), fasting insulin (FINS), fasting peptide (FPC), parathyroid hormone (iPTH), serum creatinine (SCr), blood neutrophil count, lymphocyte count, blood calcium (Ca), and blood phosphorus (P), neutrophil count (Ne), lymphocyte count (Lym), neutrophil-to-lymphocyte ratio (NLR). Results The mean 25(OH) D concentration of 33 patients with GDM was 21.40±10.68 ng/mL, among them, the patients with vitamin D insufficiency was 30.30% (10 cases), the patients with vitamin D deficiency was 60.61%(20 cases), the patients with normal vitamin D level was 9.1%(3 cases). Adjusted by age, gestational age, and glomerular filtration rate (eGFR), 25(OH)D concentration were negatively correlated to and FBG ( β = -0.587, p =0.001), HbA1c ( β = -0.408, p =0.018 ), respectively. There was a negative correlation between 25(OH)D concentrations and NLR ( β = -0.389, p = 0.035), adjusted by eGFR, gestational age, and age. Conclusions: The status of vitamin D deficiency in patients with GDM is common. With the decrease of 25(OH) D concentration, fasting blood glucose and HbA1c increase. 25(OH) D concentration is negatively correlated to NLR. Vitamin D may affect fasting blood glucose and HbA1c in patients with gestational diabetes by regulating inflammation.

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Maternal and Neonatal Metabolic Outcomes of Vitamin D Supplementation in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Cited by 23 publications

References 66 publications

Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis

Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis

STUDY of 1, 25 Dihydroxy Vitamin D Level in Term Neonates with Indirect Hyperbilirubinemia

The vitamin D status is negatively correlated to glucose metabolism in Chinese patients with gestational diabetes

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