Relationship between sex hormones and haemostatic factors in healthy middle-aged men

Bonithon‐Kopp, Claire; Scarabin, Pierre‐Yves; Bara, L.; Castanier, M; Jacqueson, A.; Roger, M

doi:10.1016/0021-9150(88)90303-6

Cited by 69 publications

(32 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our previous cross-sectional study 15) showed that plasma fibrinogen concentrations were positively associated with age, smoking, serum total cholesterol concentration, and inversely associated with serum HDL cholesterol concentration which was consistent with the results of studies in Western countries [9][10][11]29,30,[32][33][34][35][36][37][38][39][40][41][42] Although plasma fibrinogen concentrations were lower in Japanese than in American Caucasians according to our previous cross-cultured study43), the present study suggested that plasma fibrinogen is a risk factor of myocardial infarction among Japanese as so among Caucasians. Our prospective study is underway to confirm this hypothesis.…”

Section: Discussionsupporting

confidence: 73%

A Case-Reference Study on Plasma Fibrinogen Concentrations and Coronary Atherosclerosis in Japanese

Sato

Kobayashi

Iida

et al. 1996

Journal of Epidemiology

View full text Add to dashboard Cite

Shinichi Sato1,3, Toru Kobayashi1, Minoru lida1, Yoshihiko Naito1,3, Masahiko Kiyama1, Akihiko Kitamura1,Hiroyasu lso2, and Yoshio Komachi3To examine contribution of plasma fibrinogen concentrations to coronary atherosclerosis in Japanese, a cross-sectional study was conducted from 1991 to 1993 for 169 myocardial infarction cases and 1 : 1 matched references.All cases had one to three coronary vessels with 50 percent or more stenosis. References were chosen out of Osaka residents who had no cardiac event by matching sex and age (+-3 years) with cases.Mean (SD) values of plasma fibrinogen concentration were 322 (81) mg/dl in men and 377 (77) mg/dl in women for cases, and were 282 (56) mg/dl in men and 277 (48) mg/dl in women for references ; mean plasma fibrinogen was significantly higher in cases than in references for both men and women. Furthermore, mean plasma fibrinogen was progressively higher as the number of stenotic vessels increased for men, and similar trend was seen for women. The case-reference difference remained significant even after adjusting smoking status, hypertension, serum total cholesterol, serum HDL cholesterol. Although plasma fibrinogen concentration was reported lower in Japanese than in American Caucasians, plasma fibrinogen is suggested to be a risk factor for myocardial infarction among Japanese as so among Caucasians.J Epidemiol, 1996; 6 : 81-86. plasma fibrinogen ; cross-sectional study ; myocardial infarction ; coronary artery stenosis ; Japanese

show abstract

Section: Discussionsupporting

confidence: 73%

A Case-Reference Study on Plasma Fibrinogen Concentrations and Coronary Atherosclerosis in Japanese

Sato

Kobayashi

Iida

et al. 1996

Journal of Epidemiology

View full text Add to dashboard Cite

show abstract

“…Testosterone propionate administration has been reported to increase fibrinolytic activity 18 and stanozolol to decrease inhibition of t-PA. 44 In addition, an inverse correlation has been reported in healthy men between fibrinolytic capacity and E/T 45 and between a2-antiplasmin and testosterone 37 and a positive correlation between a2-antiplasmin and E/T. 37 Furthermore, Caron et al 46 found an inverse correlation between PAI-1 and plasma testosterone in men. Fibrinogen correlated positively with FT/T.…”

Section: Resultsmentioning

confidence: 99%

“…Although in the present study factor VII correlated with risk factors for CHD, it showed no correlations with the sex hormones. Others, however, found that factor VII correlated negatively with testosterone 35 - 37 and positively with E/T 37 in men. Also, the factor VII and fibrinogen levels have been reported to be elevated after contraceptive pill use in women 17 and the factor VII level to be increased about 15-fold in late pregnancy.…”

Section: Resultsmentioning

confidence: 99%

Relation of hemostatic risk factors to other risk factors for coronary heart disease and to sex hormones in men.

Yang

Jing

Resnick

et al. 1993

Arterioscler Thromb

View full text Add to dashboard Cite

The present study was carried out to explore the possible relation of plasma plasminogen activator inhibitor-1 (PAI-1), fibrinogen, and factor VII levels to other risk factors for coronary heart disease (CHD) and to serum sex hormone levels. The study group comprised 48 apparently healthy men. To avoid the confounding factor of obesity, correlations were determined in the 30 men in this group with a body mass index (BMI) <26.4, after controlling for age. PAI-1 correlated with testosterone, estradiol/ testosterone, and free testosterone/testosterone (FT/T), and fibrinogen correlated with FT/T. All three hemostatic factors correlated with glucose and with the ratio of cholesterol/high density lipoprotein cholesterol, while PAI-1 correlated with diastolic blood pressure. To test the effect of obesity, correlations were determined in the entire group of 48 men, which included 18 subjects with a BMI >26.4. All three hemostatic factors correlated with BMI in this group after controlling for age; however, on controlling for testosterone, only PAI-1 correlated with BMI. Fibrinogen correlated with age in both groups after controlling for testosterone or BMI. These correlations support the hypothesis that PAI-1, fibrinogen, and factor Vn are related to other risk factors for CHD and that an alteration in the sex hormone milieu may be the underlying factor linking them. {Arteriosclerosis and Thrombosis 1993;13:467-471) KEY WORDS • sex hormones • estradiol • testosterone • plasminogen activator inhibitor-1 • fibrinogen • factor VII

show abstract

“…Interestingly, in bovine aortic endothelial cells, testosterone, at pharmacological doses, inhibited the secretion of plasminogen activator and stimulated secretion of plasminogen activator inhibitor type I (164). Furthermore, some studies reported a negative association between testosterone and factor VII (29,44,84) and between testosterone and á 2 -antiplasmin, the main inhibitor of fibrinolysis (29). In addition, androgen treatment studies suggest a fibrinolytic effect of androgens (6,58,178).…”

Section: Androgens and The Hemostatic Systemmentioning

confidence: 99%

Cardiovascular Effects of Androgens

Weidemann

Hanke

2002

Cardiovascular Drug Reviews

View full text Add to dashboard Cite

In the process of atherosclerosis sex steroids play a complex role in the vascular vessel wall system. Although a number of experimental studies have clearly documented an atheroprotective effect of estrogens, in recent clinical studies, estrogen replacement therapy has failed to reduce cardiovascular mortality. The effects of androgens on the cardiovascular system and cardiovascular diseases are even more controversial. Whereas in the past, androgens were mainly believed to exert adverse effects on the cardiovascular system, recent studies in men have documented a number of beneficial actions of testosterone in the arterial vascular system. Androgens affect lipid metabolism (e.g., LDL and HDL cholesterol, Lp(a)) and hemostasis (e.g., platelet aggregation and fibrinolytic activity). In addition, several other physiological and pathophysiological processes in the arterial vessel wall are influenced by androgens. Acute hemodynamic effects of testosterone on coronary vasomotion and stress-test-induced ischemia were reported. Additionally, recent animal and in vitro studies have further documented an inhibitory effect of androgens on neointimal plaque formation. This review discusses different and, in part, contradictory effects of androgens on the cardiovascular system including potential signal transduction pathways in androgen target cells.

show abstract

Relationship between sex hormones and haemostatic factors in healthy middle-aged men

Cited by 69 publications

References 35 publications

A Case-Reference Study on Plasma Fibrinogen Concentrations and Coronary Atherosclerosis in Japanese

A Case-Reference Study on Plasma Fibrinogen Concentrations and Coronary Atherosclerosis in Japanese

Relation of hemostatic risk factors to other risk factors for coronary heart disease and to sex hormones in men.

Cardiovascular Effects of Androgens

Contact Info

Product

Resources

About