2002
DOI: 10.1111/j.1527-3466.2002.tb00086.x
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Cardiovascular Effects of Androgens

Abstract: In the process of atherosclerosis sex steroids play a complex role in the vascular vessel wall system. Although a number of experimental studies have clearly documented an atheroprotective effect of estrogens, in recent clinical studies, estrogen replacement therapy has failed to reduce cardiovascular mortality. The effects of androgens on the cardiovascular system and cardiovascular diseases are even more controversial. Whereas in the past, androgens were mainly believed to exert adverse effects on the cardio… Show more

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Cited by 52 publications
(39 citation statements)
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References 192 publications
(204 reference statements)
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“…This is primarily suggested to be due to androgen abuse, which has been associated with fatal consequences, including myocardial infarction, hypertension, arrhythmia, cardiac failure and sudden death [10,11]. The effect of testosterone on CVD in men has never been investigated in a clinical, double-blind, placebocontrolled study.…”
Section: Discussionmentioning
confidence: 99%
“…This is primarily suggested to be due to androgen abuse, which has been associated with fatal consequences, including myocardial infarction, hypertension, arrhythmia, cardiac failure and sudden death [10,11]. The effect of testosterone on CVD in men has never been investigated in a clinical, double-blind, placebocontrolled study.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, while it is clear that estrogens can exert antiaggregatory actions and that the endothelium is likely to play an important role in this response, the evidence is equivocal in terms of which endothelial mediator might be important in mediating this effect. In addition, another point of interest is that it is not only the female sex hormones that alter platelet activity, but also androgens have been shown to increase the production and reactivity of platelets (Shapiro et al 1999, Weidemann & Hanke 2002. What role EDHF might have to play in mediating the effects of sex hormones on platelet reactivity has not been extensively studied, but below we have reviewed the evidence that EDHF might play a role.…”
Section: Sex Difference In Platelet Functionmentioning
confidence: 99%
“…The supernatant was discarded, and pellets were resuspended in cold PBS. The mixture was layered over a 15% dextran solution (35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45) and separated by centrifugation (1,300 g for 30 -40 min at 4°C), and the pellet containing blood vessels was collected and washed with ice-cold PBS over a nylon mesh (50 m). Next, vessels were collected from the mesh using fine tip forceps and transferred to a small glass homogenizer containing lysis buffer (4°C).…”
Section: Western Blot Analysismentioning
confidence: 99%
“…This lack of information also fuels concerns about the vascular impact of testosterone therapy for elderly men (33) and postmenopausal women (28) as well as the use of anabolic androgens in young athletes, both male and female (30). Androgens appear to influence a variety of cardiovascular risk factors including lipid profile, platelet aggregation, blood pressure, and vascular reactivity (1,25,31,44). Data on vascular reactivity, however, are limited and often conflicting.…”
mentioning
confidence: 99%