Relationship between serum alkaline phosphatase level, C-reactive protein and leukocyte counts in adults aged 60 years or older

Seo, Min Seok; Shim, Jae Yong; Lee, Yong-Jae

doi:10.1080/00365513.2019.1585567

Cited by 12 publications

(18 citation statements)

References 32 publications

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“…However, after adjusting for potential confounding factors, ALP was found to be associated with CRP. Similar to a previous study based on a Korean population (17), we also find that ALP level was independently associated with leukocyte count after controlling for confounding factors. An association between elevated ALP and inflammatory markers may provide a reasonable explanation for the association of ALP and mortality.…”

Section: Discussionsupporting

confidence: 89%

“…In CKD, total ALP is generally regarded as a reliable marker of bone turnover (1,2,14). An association between serum ALP and elevated serum C-reactive protein (CRP) levels has been reported in CKD patients ( 16) and nor-CKD population (17,18). Although various studies of the biomarkers of CKD-MBD have been performed in ESRD patients, a majority of the previous studies involved patients undergoing dialysis.…”

Section: Introductionmentioning

confidence: 99%

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Mineral and bone disorder biomarkers and inflammation indexes in patients with end stage renal disease

Zhang¹,

Yu²,

Chen³

et al. 2020

Ann Palliat Med

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Background: Chronic kidney disease (CKD) is an independent risk factor for bone and mineral metabolism disorder. Bone and mineral metabolism disorder develop gradually with the progression of renal failure. Various abnormalities include elevated fibroblast growth factor-23, decreased levels of 1,25-Dihydroxy Vitamin D (1,25-(OH)2D), and secondary hyperparathyroidism. This study aimed to evaluate the biomarkers and inflammation indexes of CKD-mineral and bone disorder (MBD), and to examine the associations of serum alkaline phosphatase (ALP) levels with serum C-reactive protein (CRP) levels and leukocyte count, in patients with end-stage renal disease (ESRD).Methods: ESRD patients who were yet to initiate dialysis were enrolled as the study subjects. All CKD patients who were discharged from our hospital between January 1, 2013, and December 31, 2017, were screened.Based on quartiles of serum ALP, all subjects were categorized into four subgroups. The clinical characteristics of patients in the four subgroups were investigated. The prevalence of hypocalcemia, hyperphosphatemia, elevated intact parathyroid hormone (iPTH), and elevated CRP level was calculated in the four subgroups. The association between serum ALP and inflammation indexes was examined using regression analysis.Results: Based on the inclusion criteria and exclusion criteria, 256 cases with ESRD were included in our study. The overall prevalence of hypocalcemia and hyperphosphatemia was 57.81% and 89.84%, respectively. Of the patients with ESRD, 174 (68.75%) had an elevated iPTH level >2 times of the upper limit of normal value), and 40 (15.63%) had an elevated iPTH level >9 times of the upper limit of normal value Discrepancies between serum ALP and iPTH levels were found in 29 patients. In the adjusted model, log-transformed CRP, log-transformed iPTH, and leukocyte count were significantly associated with logtransformed ALP.Conclusions: Hypocalcemia, hyperphosphatemia, and increased levels of iPTH and CRP were found to be extremely common in ESRD patients. Discrepancies between serum ALP and iPTH were also observed.Our results also indicate that serum ALP level is associated with the levels of iPTH and CRP, as well as leukocyte count.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Mineral and bone disorder biomarkers and inflammation indexes in patients with end stage renal disease

Zhang¹,

Yu²,

Chen³

et al. 2020

Ann Palliat Med

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“…Second, chronic low‐grade inflammation plays a key role in initiating and developing of atherosclerotic process. Several experimental and clinical studies suggested that ALP was significantly correlated with low‐grade inflammation factors such as serum hsCRP, TNF‐a and IL‐1β 28,29 . Here, we speculated that the potential impacts of ALP on baPWV may involve mechanisms relating to inflammatory pathways.…”

Section: Discussionmentioning

confidence: 91%

“…Several experimental and clinical studies suggested that ALP was significantly correlated with low-grade inflammation factors such as serum hsCRP, TNF-a and IL-1β. 28,29 Here, we speculated that the potential impacts of ALP on baPWV may involve mechanisms relating to inflammatory pathways. In the present study, we found that serum ALP was independently correlated with baPWV after adjustment for white blood cell count and neutrophil count.…”

Section: Roc Curvementioning

confidence: 99%

Serum alkaline phosphatase is associated with arterial stiffness and 10‐year cardiovascular disease risk in a Chinese population

Guo

et al. 2021

Eur J Clin Investigation

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BackgroundSerum alkaline phosphatase (ALP) has been recognized as a biomarker of cardiovascular disease (CVD) risk or mortality, recently. This study aimed to explore the association of ALP with arterial stiffness and 10-year CVD risk. MethodsA total of 12539 participants without CVD who underwent health examinations including serum ALP level were retrospectively analyzed. Arterial stiffness was measured by brachial ankle pulse wave velocity (baPWV) and10-year CVD risk was evaluated by Framingham risk score (FRS). ResultsAll participants were strati ed into four groups according to the quartile of serum ALP. Participants with high ALP quartiles had higher cardiovascular parameters and baPWV, as well as an increase 10-year CVD risk. Logistic regression analysis showed that serum ALP was an independently risk factor for elevated baPWV and 10-year CVD risk after adjustment for traditional CVD risk factors in both women and men. In receiver operating characteristic (ROC) curve analysis, the area under the ROC curve (AUROC) of serum ALP for predicting elevated baPWV was 0.740 (95%CI 0.726-0.754, P < 0.001) in women, larger than that in men.

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“…In 2014, a meta-analysis reported that serum ALP levels are positively and independently associated with cardiovascular risk [13]. Although the direct mechanism has not been fully elucidated, vascular calcification [14] and inflammation [15,16] may be the common link between ALP and cardiovascular disease development.…”

Section: Study Populationmentioning

confidence: 99%

Relationship between Serum Alkaline Phosphatase and Low Muscle Mass Index Among Korean Adults: A Nationwide Population-Based Study

2021

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Sarcopenia has attracted interest due to its impact on various health problems. Chronic inflammation is an important contributor to sarcopenia. Thus, we aimed to investigate the association between serum alkaline phosphatase (ALP), which is a novel inflammatory marker, and muscle mass. This study included 15,579 adults from the 2008–2011 Korea National Health and Nutrition Survey. Low skeletal muscle mass index (LSMI) was defined as body mass index-adjusted appendicular skeletal muscle mass less than 0.789 for men and 0.512 for women. Multiple logistic regression revealed that the highest ALP tertile was significantly associated with LSMI compared with the lowest ALP tertile in both men [Odds ratio (OR): 1.41; 95% confidence interval (CI): 1.04–1.91] and women (OR: 1.45; 95% CI: 1.00–2.10) after adjusting for other confounders. On the receiver operating characteristic curve analysis, the predictive power was significantly higher for ALP levels than for white blood cell count in women (p < 0.001), whereas the difference was not significant in men (p = 0.515). Our findings suggest the potential use of serum ALP as an inflammatory marker and a predictor of sarcopenia.

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Relationship between serum alkaline phosphatase level, C-reactive protein and leukocyte counts in adults aged 60 years or older

Cited by 12 publications

References 32 publications

Mineral and bone disorder biomarkers and inflammation indexes in patients with end stage renal disease

Mineral and bone disorder biomarkers and inflammation indexes in patients with end stage renal disease

Serum alkaline phosphatase is associated with arterial stiffness and 10‐year cardiovascular disease risk in a Chinese population

Relationship between Serum Alkaline Phosphatase and Low Muscle Mass Index Among Korean Adults: A Nationwide Population-Based Study

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