Relationship between Serum Alkaline Phosphatase and Low Muscle Mass Index Among Korean Adults: A Nationwide Population-Based Study

Lee, Jun‐Hyuk; Cho, A-Ra; Lee, Yong-Jae

doi:10.3390/biom11060842

Cited by 8 publications

(5 citation statements)

References 35 publications

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“…Moreover, higher FPG (in men aged 65–74 years) is speculated to be related to lower basal insulin secretion or possibly excessive alcohol intake, which makes elevated morning glucose positively correlated with sarcopenia among men. AST (in women aged 65–74 years) was previously reported 9 to be directly related to skeletal muscle mass. Cr (in women aged ≥75 years), which had wide CIs, and eGFR (among women) were risk factors for a positive Yubi-wakka test result.…”

Section: Discussionmentioning

confidence: 95%

Sarcopenia and coexistent risk factors detected using the ‘Yubi-wakka’ (finger-ring) test in adults aged over 65 years in the public annual health check-up in Tama City, Tokyo: a cross-sectional study

Fujii¹,

Kodani

Kaneko

et al. 2022

BMJ Open

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ObjectivesTo examine the positive rate of sarcopenia using the ‘Yubi-wakka’ (finger-ring) test and associated risk factors among adults aged 65 years and older.DesignCross-sectional study.SettingWe used the Yubi-wakka test, which has been developed and validated as a predictor of sarcopenia, frailty, disability and mortality. A positive test result is indicated by a smaller calf circumference than the finger-ring. The test was administered during annual health check-ups among residents of Tama City, Japan.ParticipantsDuring the 2019 fiscal year, 12 894 individuals aged 65 years and older underwent the Yubi-wakka test at primary care clinics.InterventionsExaminees conducted the test themselves in a seated position. They formed a ring around their calf using both thumbs and index fingers and judged whether their calf was larger, the same or smaller than their finger-ring.Primary and secondary outcome measuresWe compared anthropometric and serological data between the positive (smaller calf) and negative (larger calf) test result groups.ResultsThe positive rate was 15.4% among men and 18.5% among women. The prevalence of a positive result was higher in those aged ≥80 years than in younger age groups in both sexes (men: 22.8%; women: 28.8%). Multivariate logistic regression analysis showed that a diagnosis of metabolic syndrome was a risk factor for detecting a positive test result in women aged 65–74 years (OR 3.445; 95% CI 1.44 to 8.29) and ≥75 years (OR 3.37; 95% CI 1.97 to 5.78).ConclusionsBecause the Japanese population is healthy and lives long, interventions against sarcopenia are important, especially for older adults aged >75 years. The presence of metabolic syndrome may be a risk factor for sarcopenia (as detected by the Yubi-wakka test) and future frailty, and requires closer attention, especially among women.

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Section: Discussionmentioning

confidence: 95%

Sarcopenia and coexistent risk factors detected using the ‘Yubi-wakka’ (finger-ring) test in adults aged over 65 years in the public annual health check-up in Tama City, Tokyo: a cross-sectional study

Fujii¹,

Kodani

Kaneko

et al. 2022

BMJ Open

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“…Further, we investigated the content of alkaline phosphatase, the activity of which, according to literature data, changes in skeletal muscle pathology [25]. The highest levels of alkaline phosphatase were found in children from group 1, while in patients with diabetic myopathy, its serum content was not statistically different from the control group (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the established decrease in serum content of this enzyme with the progression of structural and functional changes in skeletal muscles of children with diabetes seems logical. It is possible that an increased activity of alkaline phosphatase in patients with preserved mass and strength of skeletal muscles may be due to the development of nonspecific low-grade inflammation and oxidative stress against the background of hyperglycemia [31], which acts as a factor of skeletal muscle fibrosis [32] and a trigger for muscle loss [25]. As chronic oxidative stress progresses, alkaline phosphatase activity decreases.…”

Section: Discussionmentioning

confidence: 99%

Functional and biochemical characteristics of the muscle system in children with type I diabetes

Lezhenko

Pashkova

Samoylyk

et al. 2022

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Background. The purpose of the study was to determine possible markers of skeletal muscle damage in children with type 1 diabetes mellitus (T1DM) and their relationship with the features of disease course. Materials and methods. The observation group consisted of 98 children with type 1 diabetes mellitus: the first group included 22 people without disorders of the muscular system; the second — 42 patients with dynapenia; the third — 34 children with diabetic myopathy. Control group — 30 relatively healthy children. Assessment of the static endurance of skeletal muscles, determination of the level of creatine kinase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, periostin and cardiotrophin-1 in blood serum were performed in all patients. Results. The conducted studies demonstrate that children with diabetes, regardless of the structural and functional state of their muscular system, have signs of skeletal muscle damage, which were most expressed in diabetic myopathy and progressed with maximal deterioration of glycemic control. It was found that the highest content of alkaline phosphatase was characteristic of children from group 1, while in patients with diabetic myopathy its serum content was not statistically different from that of controls. These disorders occurred against the background of changes in alkaline phosphatase activity, the level of which was highest in children from group 1, while in patients with diabetic myopathy, its serum content was not statistically different from that of controls. At the same time, during the course of diabetic myopathy in children with T1DM, there was an increase in lactate dehydrogenase activity by 1.2 times (p < 0.01) and cardiotrophin-1 by 300 times (p < 0.01) compared to the corresponding indicator of the control group. Serum periostin level was increased in all patients with T1DM. Its maximum values were determined in group 1, whose periostin concentration exceeded control indicators by 103 times (p < 0.01). With deterioration of skeletal muscle state, there was a gradual decrease in periostin serum level, but in patients with dynapenia, it was 35.5 times higher than in the control group (p < 0.05) and 19.2 times higher in those with diabetic myopathy (p < 0.05). Conclusions. The course of type 1 diabetes in children is accompanied by skeletal muscle damage, the first clinical sign of which is a decrease in the static muscle endurance against the background of worsening disease course. Alkaline phosphatase, lactate dehydrogenase, periostin, and cardiotrophin-1 are biochemical markers of skeletal muscle damage in children with type 1 diabetes. A common feature of the changes in the specified indicators is their increase; however, each clinical condition of the skeletal muscles corresponds to its own configuration of changes in the abovementioned markers.

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“…High ALP levels were also associated with the development of sarcopenia in cirrhotic patients. Lee et al [32] explored the relationship between serum ALP levels and low muscle mass index in 15,579 adults in Korea, and the ndings suggested that serum ALP may serve as a marker of in ammation and a predictor of sarcopenia. Further research is needed to con rm whether ALP can predict sarcopenia development in cirrhosis patients.…”

Section: Discussionmentioning

confidence: 99%

Assessing the risk factors associated with sarcopenia in patients with cirrhosis: a case-control study

Xiao,

Dai,

Zhao

et al. 2023

Preprint

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The study investigated sarcopenia prevalence and associated factors in cirrhosis patients admitted from July 2021 to November 2022. Of 271 participants, 27.7% had sarcopenia. Prevalence was higher in ≥60-year-olds (38.3%) and those exercising <3 times/week (36.4%). Binary regression analysis identified factors linked to sarcopenia. Lower body mass index (BMI) (OR 0.663; 95% CI 0.551–0.799, p < 0.001), mid-upper arm muscle circumference (OR 0.833; 95% CI 0.716–0.969, p = 0.018), albumin (OR 0.831; 95% CI 0.762–0.907, p < 0.001), and total cholesterol (OR 0.389; 95% CI 0.230–0.659, p < 0.001) were negatively correlated with sarcopenia. Conversely, exercise <3 times/week (OR 2.498; 95% CI 1.063–5.874, p = 0.036), hepatic encephalopathy (OR 3.658; 95% CI 1.539–8.694, p = 0.003), high malnutrition risk (OR 2.579; 95% CI 1.127–5.898, p = 0.025), high alkaline phosphatase level (OR 1.007; 95% CI 1.003–1.011, p < 0.001), and age (OR 2.688; 95% CI 1.012–7.137, p = 0.047) were positively correlated with sarcopenia. Adjusting for gender weakened the age-sarcopenia link. In conclusion, sarcopenia was prevalent in cirrhosis patients, with age, physical activity, BMI, nutritional status, and albumin independently associated with it. Serum ALP and total cholesterol were linked to sarcopenia development. Regular exercise may help maintain grip strength and delay liver function deterioration in cirrhotic individuals.

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Relationship between Serum Alkaline Phosphatase and Low Muscle Mass Index Among Korean Adults: A Nationwide Population-Based Study

Cited by 8 publications

References 35 publications

Sarcopenia and coexistent risk factors detected using the ‘Yubi-wakka’ (finger-ring) test in adults aged over 65 years in the public annual health check-up in Tama City, Tokyo: a cross-sectional study

Sarcopenia and coexistent risk factors detected using the ‘Yubi-wakka’ (finger-ring) test in adults aged over 65 years in the public annual health check-up in Tama City, Tokyo: a cross-sectional study

Functional and biochemical characteristics of the muscle system in children with type I diabetes

Assessing the risk factors associated with sarcopenia in patients with cirrhosis: a case-control study

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