Relationship between plasma leptin and zinc levels and the effect of insulin and oxidative stress on leptin levels in obese diabetic patients

Konukoğlu, Dildar; Turhan, Mehtap Sultan; Ercan, Meltem; Özden, Sibel

doi:10.1016/j.jnutbio.2004.07.007

Cited by 52 publications

(30 citation statements)

References 30 publications

(28 reference statements)

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“…19,20 Zinc also plays an important role in appetite regulation and may thus be expected to act as a mediator of leptin effects. 21 Studies 17,22,23 have shown low leptin levels in states of zinc deficiency. Furthermore, zinc supplementation seems to increase circulating leptin levels, 22,24 thus showing a connection between zinc and leptin.…”

Section: Introductionmentioning

confidence: 99%

The response of serum leptin, cortisol and zinc concentrations to concurrent training

Rosa¹,

Dantas²,

Mello³

2011

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ObjectIve: to investigate the effects of concurrent training (ct) on serum leptin, cortisol and zinc concentrations in physically active adults. DesIGN: ten subjects aged (27.1±4.8 years, bMI 25.49 ± 2.65) were recruited to participate in three sessions: control session (cs), concurrent training 1 (ct1) and concurrent training 2 (ct2) sessions with five days of resting between them. In each session blood samples for leptin, cortisol and zinc determination were collected. ct1 session included indoor cycling class followed by strength training. ct2 session included strength training, followed by indoor cycling class. In cs there were no exercises. the shapiro-Wilk test, repeated ANOvA test and tukey Post-Hoc test were used. resULts: there was a reduction in leptin levels after CT1 (Δ% = -16.04; p = 0.05) and CT2 (Δ% = -8.54; p = 0.02). Cortisol also showed a reduction after CT1 (Δ% = -26.32; p = 0.02) and CT2 (Δ% = -33.57; p = 0.05), whereas zinc did not show any significant alterations after any of the training sessions. there was also significant difference for the leptin and cortisol values between ct1 and ct2. cONcLUsIONs: ct promoted reduction in serum leptin and cortisol levels independently of the training order, while no significant changes in zinc concentrations were observed.

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Section: Introductionmentioning

confidence: 99%

The response of serum leptin, cortisol and zinc concentrations to concurrent training

Rosa¹,

Dantas²,

Mello³

2011

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“…Zinc also plays an important role in appetite regulation by influencing the leptin system and insulin secretion [27]. During pregnancy, requirements are particularly high because zinc is essential for growth and development of foetal and maternal tissue.…”

Section: Introductionmentioning

confidence: 99%

Zinc Deficiency: A Frequent and Underestimated Complication After Bariatric Surgery

Sallé

Demarsy

Poirier³

et al. 2010

OBES SURG

107

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“…2 b) at the beginning and after 3 months of following the diet, due to a lack of subcutaneous adipose tissue. However, this result did not rule out the possibility of leptin sensitization by zinc [16,17] .…”

Section: Discussionmentioning

confidence: 63%

“…Zinc plays a key role in the synthesis, storage, and secretion of insulin as well as in the conformational integrity of insulin in the hexameric form [15] . Zinc also plays an important role in appetite regulation, as it alters hypothalamic neurotransmitter metabolism by influencing the leptin system [16,17] .…”

mentioning

confidence: 99%

Effect of Diet Intervention and Oral Zinc Supplementation on Metabolic Control in Berardinelli-Seip Syndrome

Rocha¹,

Leite

Baracho³

et al. 2010

Ann Nutr Metab

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Background/Aims: Berardinelli-Seip syndrome (BSS), also termed congenital generalized lipodystrophy or congenital generalized lipoatropic diabetes, is a rare autosomal recessive disease characterized by the nearly complete absence of metabolically active adipose tissue from birth, extreme insulin resistance, diabetes mellitus, and hepatomegaly. The aim of this study was to evaluate the effect of diet intervention and oral zinc supplementation on the metabolic control of BSS patients. Methods: During a 3-month period, 10 BSS patients received individualized diets and oral zinc supplementation. Food intake, clinical laboratory parameters, serum zinc and leptin, and plasma C-peptide concentrations were evaluated at the beginning of the study and after 3 months. Results: At the beginning of the study, all patients had elevated energy, protein, total fat, carbohydrate, calcium, iron, and zinc intakes. After 3 months, all of these parameters had decreased. Total fiber intakes remained low before and after diet intervention and oral zinc supplementation, and plasma levels of fasting glucose remained high. In contrast, glycated hemoglobin decreased significantly. Plasma leptin, C-peptide, and serum zinc levels increased during venous zinc tolerance testing, but there were no significant differences between the 2 curves obtained before and after diet intervention and oral zinc supplementation. Conclusions: Diet intervention and oral zinc supplementation were effective at controlling energy consumption, macronutrients, and glycated hemoglobin. Zinc likely acts as an adjunct therapy, thereby improving the effectiveness of leptin.

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Relationship between plasma leptin and zinc levels and the effect of insulin and oxidative stress on leptin levels in obese diabetic patients

Cited by 52 publications

References 30 publications

The response of serum leptin, cortisol and zinc concentrations to concurrent training

The response of serum leptin, cortisol and zinc concentrations to concurrent training

Zinc Deficiency: A Frequent and Underestimated Complication After Bariatric Surgery

Effect of Diet Intervention and Oral Zinc Supplementation on Metabolic Control in Berardinelli-Seip Syndrome

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