Relationship between periodontal disease and diabetes mellitus: an Asian perspective

Taiyeb-Ali, Tara B.; Raman, Rajagopalan; Vaithilingam, Rathna Devi

doi:10.1111/j.1600-0757.2010.00370.x

Cited by 28 publications

(35 citation statements)

References 94 publications

(107 reference statements)

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“…The inflammatory reaction in CP is defined by localized stimulation of inflammatory mediators. DM changes the immunologically active molecules by raising the amounts of cytokines present in periodontal tissues, and in turn this aggravates the development of the disease (43).…”

Section: Discussionmentioning

confidence: 99%

Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus

et al. 2016

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Abstract:The aims of the present study were to determine the levels of vaspin and omentin-1 in gingival crevicular fluid (GCF) in patients with chronic periodontitis (CP) with and without type 2 diabetes mellitus (T2DM), and to evaluate GCF vaspin and omentin-1 levels after non-surgical periodontal therapy. The study included 60 subjects: 15 systemically and periodontally healthy individuals, 15 periodontally healthy patients with T2DM, 15 systemically healthy patients with CP, and 15 patients with both CP and T2DM. GCF and clinical periodontal parameters were examined at the baseline and 6 weeks after periodontal therapy. Levels of vaspin, omentin-1 and tumor necrosis factor-alpha (TNF-α) were measured by ELISA, and their relative ratios were calculated. GCF vaspin and TNF-α levels were significantly higher in the CP groups than in the periodontally healthy groups (P < 0.008) and decreased after therapy in the former (P < 0.025). GCF omentin-1 levels were significantly lower in the CP groups than in the periodontally healthy groups (P < 0.008) and increased after therapy in the former (P < 0.05). Statistically significant positive correlations were found between the total amount of vaspin and TNF-α, glycated hemoglobin (HbA1c), clinical attachment level and gingival index, whereas the level of omentin-1 was negatively correlated with these parameters in all groups (P < 0.05). We found that non-surgical periodontal therapy influenced the GCF levels of both vaspin and omentin-1 in the CP groups. IntroductionChronic peridontitis (CP) is an infectious condition that degrades and deteriorates the vital periodontal tissues around the teeth (1). The deterioration of soft and hard tissues resulting from periodontitis is due to stimulation of the host immunoinflammatory reaction to pathogens in the mouth (2). The host response to these infectious pathogens leads to dispersal of inflammatory mediators, including the pro-inflammatory cytokines interleukin-1 (IL-1), IL-6, tumor necrosis factor alpha (TNF-α), and prostaglandins (PGE2), the latter exacerbating deterioration of the periodontium. The increased cytokine levels present in periodontitis are also likely to aggravate existing conditions, such as atherosclerosis, diabetes, and rheumatoid arthritis (3). A number of theories have been offered to explain the

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Section: Discussionmentioning

confidence: 99%

Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus

et al. 2016

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“…For instance, they both present increased immuno‐inflammatory responses with similar biologic mediators 9 . The progression of DM and periodontitis comes only after mild inflammation and an increase in plasma and gingival crevicular fluid (GCF) levels of proinflammatory markers such as C‐reactive protein, tumor necrosis factor (TNF)‐α, cytokines (interleukin [IL]‐1β), IL‐6, and prostanoids 10 . Within this environment, proteins (adipokines) produced by the adipose tissue and the tissue defense cells are likely to play a role in any kind of inflammatory reaction.…”

mentioning

confidence: 99%

Chemerin as a Novel Crevicular Fluid Marker of Patients With Periodontitis and Type 2 Diabetes Mellitus

Doğan

Ballı

Dede

et al. 2016

Journal of Periodontology

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“…Furthermore, the interaction between advanced glycation end products (AGEs) and their receptors mediate systemic degradation of connective tissue including periodontal tissue. Similarly, periodontitis has been associated with increased insulin resistance due to an increase in serum cytokines such as tumor necrosis factor α, interleukin 1, interleukin 6, and C reactive proteins [1].…”

Section: Introductionmentioning

confidence: 99%

Effect of Non-Surgical Therapy on Salivary Nitric Oxide and Lipid Peroxidation Levels in Type Ii Diabetic and Non Diabetic Patients With Periodontal Disease

Latha

Uppoor

Nayak

et al. 2018

Asian J Pharm Clin Res

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Objective: Reactive oxygen species have been identified as potential factors causing periodontal tissue destruction. Elevated levels of these in patients with chronic periodontitis and diabetes may aggravate the oxidative stress burden thereby accelerating the tissue damage associated with diabetes. The present study aimed to assess the effect of diabetes and periodontal disease on the oxidative stress markers and the effect of non-surgical therapy on these markers.Methods: A total of 50 participants were divided into four groups based on the selection criteria. In addition to clinical parameters and biochemical parameters (salivary nitric oxide [NO] and malondialdehyde [MDA] levels) were assessed using spectrophotometric method at baseline and 3 months after non-surgical periodontal therapy.Result: There was a statistically significant difference in the clinical parameters as well as NO and MDA levels in patients with type 2 diabetes and chronic periodontitis than other three groups at baseline and at 3 months after non-surgical periodontal therapy. Conclusion:Diabetes mellitus and periodontitis have a compounding effect on the oxidative stress. Periodontal therapy is essential for diabetic patients as it can lower the levels of oxidative damage.

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Relationship between periodontal disease and diabetes mellitus: an Asian perspective

Cited by 28 publications

References 94 publications

Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus

Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus

Chemerin as a Novel Crevicular Fluid Marker of Patients With Periodontitis and Type 2 Diabetes Mellitus

Effect of Non-Surgical Therapy on Salivary Nitric Oxide and Lipid Peroxidation Levels in Type Ii Diabetic and Non Diabetic Patients With Periodontal Disease

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