Chemerin as a Novel Crevicular Fluid Marker of Patients With Periodontitis and Type 2 Diabetes Mellitus

Abstract

In this study, periodontitis and t2DM induced aberrant secretion of chemerin, and non-surgical periodontal therapy influenced the decrease of GCF chemerin levels in patients with CP with and without t2DM. Furthermore, it suggests GCF chemerin levels may be considered a potential proinflammatory marker for diabetes, periodontal disease, and treatment outcomes.

Salivary, gingival crevicular fluid and serum levels of ghrelin and chemerin in patients with periodontitis and overweight

“…Chemerin levels were elevated in the gingival crevicular fluid of both study groups with chronic periodontitis and there was no statistically significant difference related to the body weight. This is partly in accordance with other recent studies in which higher levels of chemerin were also exhibited in the gingival crevicular fluid of patients with chronic periodontitis and the highest values were found where type-2 diabetes 46,47 or obesity 48 was also present. In contrast to our results with no differences in saliva, Özcan et al 21 measured higher chemerin levels in the saliva of patients with periodontitis.…”

Chemerin and interleukin‐6 levels in obese individuals following periodontal treatment

“…Four clinical studies have explored the involvement of chemerin in periodontitis (Ozcan et al , , ; Patnaik et al , ; Dogan et al , ). (Duzagac et al , ).…”

“…Our results are not directly comparable with any other, for no other research has as yet considered non‐surgical periodontal therapy effects on chemerin in obese individuals. However, two recent clinical studies have examined non‐surgical periodontal therapy effects on chemerin levels in saliva and GCF (Dogan et al , ; Ozcan et al , ). Another clinical study by Ozcan et al () showed that chemerin levels in saliva were higher in periodontitis individuals than those of healthy individuals and decreased at 6 months after periodontal therapy (Ozcan et al , ).…”

“…The strips were put into closed and numbered plastic microcentrifuge cases. The liquid was weighed again, immediately after collection, to take evaporation into account (Tuter et al , ; Dogan et al , ). Those with visible saliva or blood were subsequently discarded, with two from each individual were placed in a singular Eppendorf tube and made into a unified sample, which was immediately stored at −80°C until analysis.…”

Remodeling adipose tissue inflammasome for type 2 diabetes mellitus treatment: Current perspective and translational strategies

“…A positive cross talk between chemerin levels and impairment of glucose tolerance has been observed . In patients with chronic periodontitis and T2DM, chemerin levels in gingival crevicular fluid (GCF) were elevated compared with chronic periodontitis patients, suggesting that GCF chemerin can be a proinflammatory marker for diabetes and periodontal disease . Chemerin receptor, ChemR23 (also called CMKLR1) antagonist CCX832, was shown to reduce chemerin‐stimulated arterial contraction ex vivo and very recently shown to improve vascular function in obese diabetic mice .…”