Chemerin and interleukin‐6 levels in obese individuals following periodontal treatment

Abstract

It could be concluded that chemerin levels may act as both diagnostic and prognostic indicators. Chemerin may also play an integral part in the pathologic mechanisms that relate adipokines to both periodontal disease and obesity.

Salivary, gingival crevicular fluid and serum levels of ghrelin and chemerin in patients with periodontitis and overweight

“…Chemerin levels were elevated in the gingival crevicular fluid of both study groups with chronic periodontitis and there was no statistically significant difference related to the body weight. This is partly in accordance with other recent studies in which higher levels of chemerin were also exhibited in the gingival crevicular fluid of patients with chronic periodontitis and the highest values were found where type‐2 diabetes or obesitywas also present. In contrast to our results with no differences in saliva, Özcan et al .…”

“…Immunomodulatory effects of chemerin might be both inflammatory and anti‐inflammatory. The potential inflammatory function of chemerin in periodontitis might be underlined by the fact that the levels of chemerin in gingival crevicular fluid and saliva decreased after periodontal therapy. In synovial fibroblasts, chemerin increased expression of toll‐like receptor 4 and of the chemokine (C‐C motif) ligand 2 .…”

Levels of serum retinol‐binding protein 4 before and after non‐surgical periodontal treatment in lean and obese subjects: An interventional study

“…In the present study, we have observed elevated levels of RBP4 and TNF‐α in our population with periodontitis and a decrease in said levels after periodontal treatment, with a positive correlation between the two parameters. A significant drop in TNF‐α levels following periodontal treatment has been reported in previous studies (Altay, Gürgan, & Agbat, ; Balli, Ongoz Dede, Bozkurt Dogan, Gulsoy, & Sertoglu, ; Duzagac et al., ; Zuza et al., ). Indeed, levels of TNF‐α and RBP4 have been interrelated in other pathologies, for example in psoriasis, an autoimmune inflammatory disease in which treatment with anti‐TNF‐α has been found to reduce levels of RBP4 (Pina et al., ).…”

Association between obesity and adipokines levels in saliva and gingival crevicular fluid: A systematic review and meta‐analysis

“…For this latter comparison, however, no P ‐value was provided. By contrast, one study demonstrated that the levels of chemerin in GCF of individuals with obesity were higher than their peers of normal weight.…”

“…Another important variable that must be considered is the oral status of studies’ participants . As demonstrated, periodontal disease interferes in adipokine levels in blood, saliva, and GCF . Moreover, other conditions affecting the oral cavity, such as squamous cell carcinoma and dental caries, may also have an impact on the production of inflammatory biomarkers in saliva and GCF.…”