Relation of Serum Uric Acid Level And Essential Hypertension Among Patients Without Metabolic Syndrome

Kashem, MA; Hossain, MZ; Ayaz, Kmf; Alam, Muhammad; Khan, MH; Alam, Abmm; Azad, Kak; Karim, Md. Abdul

doi:10.3329/jdmc.v20i1.8563

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…Our results were similar to the several other studies. [20][21][22][23][24][25] In favour of our study Assob JCN et al observed that the serum uric acid level in prehypertensive group was significantly higher than control group (p<0.0001) and SUA was found to be positively correlated with SBP and DBP (p<0.0001). 26 In contrast to our study, Hamdani IHAL observed no significant difference in serum uric acid level between hypertensive patients and control group.…”

Section: Discussioncontrasting

confidence: 35%

Hyperuricaemia and essential hypertension: a case control study in Southern Rajasthan

et al. 2016

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INTRODUCTIONLife is not merely to be alive, but to be healthy and wealthy. Despite incredible improvement in health since 1950, cardiovascular disease remains among the leading causes of death worldwide. Hypertension (HT) is the most common risk factor for cardiovascular morbidity and mortality. This positive relationship between blood pressure (BP) and cardiovascular risk has been shown to exist not only in those with higher BP but also in individuals with high-normal BP/prehypertension. 1 Prehypertension as the name suggests that it precedes the hypertension. Trends in hypertension prevalence in India have shown a high prevalence of hypertension in both urban and rural areas. The prevalence rates of hypertension among urban population are 36.4% and rural people are 21.2%. 2 ABSTRACTBackground: Hypertension is one of the current emerging community health problems, which is very common affecting one in four individuals. Hyperuricemia is predictive for the development of both hypertension and coronary artery disease. Since there are various etiological factors associated with hypertension so it is very difficult to predict which one is the most common cause of hypertension. Little or no information is present in the population of Rajasthan, on the association between serum uric acid and essential hypertension. Hence this study is carried out to investigate the existence of an association between serum uric acid and essential hypertension. Methods: In this hospital based case control study, a total of 75 newly diagnosed essential hypertensive cases, 75 prehypertensive cases and 50 normotensive healthy controls, aged 20-50 years of both sexes were enrolled after excluding gout, diabetes mellitus, cardiovascular diseases, renal diseases, metabolic syndrome, secondary hypertension or history of having relevant drugs by taking detailed history and physical examination. Serum uric acid was measured in all study cases as well as control subjects. Results:The results of our study revealed that the mean serum uric acid level and the frequency of subjects with increased serum uric acid level were significantly higher in newly diagnosed cases of essential hypertension as compared to prehypertensive and normotensive controls (p< 0.001). Serum uric acid correlated positively with systolic blood pressure (SBP) (r= + 0.23, p<0.05) and diastolic blood pressure (DBP) (r= + 0.09, p>0.05). These results indicate a definite association between hyperuricaemia and essential hypertension. Conclusions: In the present study, Elevated level of SUA is significantly linked with PreHT and EHT after controlling various confounding factors. The present study showed that the number of hyperuricaemic individuals and mean SUA level were significantly higher in newly diagnosed cases of hypertension as compared to prehypertensive and normotensive control.

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Section: Discussioncontrasting

confidence: 35%

Hyperuricaemia and essential hypertension: a case control study in Southern Rajasthan

et al. 2016

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“…[4][5][6][7][8][9] In a previous study in Bangladesh, the observed prevalence of hyperuricemia in hypertensive and normotensive subjects were 25.4% and 9.8%, respectively. 29 In the present study, hyperuricemia was observed in 29.7% of hypertensive patients and 6.0% of normotensive controls, which was similar to most of the studies dine in this part of the world. The mean serum uric acid level was higher in the hypertensive patients than the normotensive controls in the present study.…”

Section: Discussionsupporting

confidence: 92%

“…Previous researchers had similar observations. [4][5][6][7][8][9]29 Among the hypertensive subjects of the current study, those with stage II HTN had significantly higher uric acid than those with stage I HTN. The higher uric acid levels with higher stages of HTN were also described by Neki et al, and Meti et al 8,19 Moreover, both the systolic and diastolic BP had significant positive correlations with serum uric acid levels in the hypertensive subjects of this study.…”

Section: Discussionmentioning

confidence: 99%

Serum uric acid level in Bangladeshi adults with essential hypertension

et al. 2020

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Background: The association of hyperuricemia with various cardiovascular risk factors has often led to the debate of whether hyperuricemia is an independent risk factor for essential hypertension (HTN). The current study was conducted to see the relationship between serum uric acid and essential HTN in Bangladeshi adults.Methods: In this cross-sectional study, conducted in a tertiary hospital of Bangladesh, 155 patients with essential hypertension (newly detected or on treatment) aged ≥18 years and 100 age-sex matched normotensive subjects were investigated. Serum uric acid, plasma glucose, serum creatinine, and lipid profile were measured in all in fasting samples.Results: The frequency of hyperuricemia was higher in the hypertensive group in comparison to the normotensive control group (29.7% vs. 6.0%, p<0.001). Serum uric acid level was higher in the hypertensive subjects than the controls (6.10±0.88 vs. 5.38±0.54 mg/dL, mean±SD, p<0.001). In the hypertensive group, subjects with stage II HTN had higher serum uric acid than those with stage I HTN (6.46±0.83 vs. 5.72±0.78 mg/dL, mean±SD, p<0.001). In the hypertensive group, uric acid level showed significant positive correlations with both systolic and diastolic blood pressure though in the control group uric acid showed such correlation with systolic BP only.Conclusion: Patients with essential hypertension had higher serum uric acid compared to normotensive controls; uric acid level showed positive correlations with systolic and diastolic BP in the hypertensive subjects.

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“…Another study shows 33% population with hypertension had high serum uric acid level 21 . A study of our country observed 25.4% of study populations had hyperuricemia with hypertension 20 . In the present study it was revealed that serum creatinine was (p=0.752) not associated with serum uric acid level and did not agree with Nishida 6 .…”

Section: Discussionmentioning

confidence: 78%

Relationship Between Uric Acid Level and Blood Pressure in T2DM Patient Attending in BIRDEM General Hospital

Ferdous

Begum

Muttalib

2018

Bangladesh J Med Biochem

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IntroductionHyperuricemia is becoming an increasing problem all over the world with a steady increase in prevalence 4 . Many factors contribute to hyperuricemia eg: genetics, insulin resistance, hypertension, renal insufficiency, obesity, diet, use of diuretics, and consumption of alcoholic beverages 3 . Some experimental and clinical studies suggest that uric acid has a contributory role in the pathogenesis of elevated blood pressure by several mechanisms such as inflammation, vascular smooth muscle cell proliferation in renal microcirculation, and activation of renin-angiotensin-aldosterone system 7 . Another study showed high arterial tension in gout due to higher level of uric acid in the blood increases tone of arterioles causing hypertension 8 . Several recent small clinical trials have demonstrated that serum uric acid lowering agents such as allopurinol and probenecid can reduce blood pressure (BP) in adolescents 9 . Some studies also showed that the subjects with higher levels of serum uric acid are more at risk of developing type 2 diabetes and it was also found that one-quarter of diabetic cases can be attributed to a high serum uric acid level 10 . Recent studies have introduced serum uric acid as a potential risk factor for hypertension, stroke and cardiovascular diseases [11][12][13] . A study showed the prevalence of hyperuricemia to be 33% of RELATIONSHIP BETWEEN URIC ACID LEVEL AND BLOOD PRESSURE IN T2DM PATIENTS ATTENDING THE BIRDEM GENERAL HOSPITAL ABSTRACTHyperuricemia is associated with higher mortality in patients suffering from hypertension, coronary heart disease, cerebrovascular events, metabolic syndrome, insulin resistance, gout and renal stone formation and it is more in individuals with diabetes. The prevalence of hyperuricemia is high in T2DM. The aim of the present study was to assess the relationship between hyperuricemia and blood pressure in T2DM subjects and thus to help the clinician for early diagnosis, treatment and to prevent further complications. Total 350 study subjects were enrolled for this study; among them 203 were T2DM with normal level of serum uric acid level and 147 were T2DM with high serum uric acid level. It was observed that systolic blood pressure was significantly higher (134.5±9.6 mm of Hg) in T2DM with hyperuricemia (p<0.001) than T2DM with normal serum uric acid level (123.3±10.9 mm of Hg). On the other hand diastolic blood pressure was significantly higher (87.1±5.9 mm of Hg) in T2DM with hyperuricemia (p<0.001) than T2DM with normal serum uric acid level (79.6±8.3 mm of Hg). Age (years) showed no significant difference between T2DM with serum uric acid<7 mg/dl and T2DM with serum uric acid>7 mg/dl (p<0.05). In our study it was revealed that males were in greater risk of developing hyperuricemia. BMI was significantly (p<0.001) greater in T2DM subjects who had normal serum uric acid level (27.9±3.8) than with those who had serum uric acid>7 mg/dl (24.4±3.83). No significant differences were found in FBS, blood sugar 2 hours after breakfast, HbA1C, seru...

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Relation of Serum Uric Acid Level And Essential Hypertension Among Patients Without Metabolic Syndrome

Cited by 4 publications

References 10 publications

Hyperuricaemia and essential hypertension: a case control study in Southern Rajasthan

Hyperuricaemia and essential hypertension: a case control study in Southern Rajasthan

Serum uric acid level in Bangladeshi adults with essential hypertension

Relationship Between Uric Acid Level and Blood Pressure in T2DM Patient Attending in BIRDEM General Hospital

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