Currently, the assessment of the quality of life is the one of the criteria for an overall assessment of the health of children. The article presents an analysis of the results of research on the effect of school performance on indices of the quality of life of adolescents. With the help of a questionnaire the PedsQL was calculated for each child physical, emotional, social spheres, as well as school performance and overall score. The study involved 2630 children of school age from 13 to 18 years: 1339 girls and 1291 boys. The survey was conducted by interviewing teenagers in the city of Izhevsk and 24 regional centers of the Republic of Udmurtia. As a result it was found that the better a child learns, he has the more quality of life. The older students show worst indices of the quality of life. Groups of teenagers “Excellent”, “good” and “satisfactory” have no discernible performance in all aspects, except for “the functioning of the school”. The main aspect of quality of life is the functioning of the school. The functioning of the school, as an index of the quality of life, has a ladder type: the better the academic performance of a teenager, the significantly higher is the aspect of “functioning of the school”. When comparing the gender indices of the quality of life, depending on the overall trend of progress is maintained: a good performance is a decent quality of life quality indices. It is the best to socialized in society boys in school “good” and “satisfactory”. It is necessary to take into account the results obtained in the development of educational and rehabilitation programs among adolescents